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    tay tay bridge [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 32547, updated on 9-Dec-2024

    Summary

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    Official Symbol
    tayprovided by FlyBase
    Official Full Name
    tay bridgeprovided by FlyBase
    Primary source
    FLYBASE:FBgn0260938
    Locus tag
    Dmel_CG9056
    See related
    AllianceGenome:FB:FBgn0260938
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG9056; dAUTS2; Dmel\CG9056; l(1)13Ff; l(1)14Ac; l(1)XI; Tay; XI
    Summary
    Involved in several processes, including adult walking behavior; imaginal disc-derived wing vein morphogenesis; and pattern orientation. Located in nucleus. Is expressed in several structures, including embryonic/larval salivary gland; imaginal disc; larval central nervous system; presumptive embryonic/larval central nervous system; and spermatozoon. Used to study alcohol use disorder. Human ortholog(s) of this gene implicated in autosomal dominant intellectual developmental disorder 26. Orthologous to human AUTS2 (activator of transcription and developmental regulator AUTS2); FBRS (fibrosin); and FBRSL1 (fibrosin like 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See tay in Genome Data Viewer
    Location:
    13F17-13F17; 1-52 cM
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (15876368..15887311, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (15770401..15781344, complement)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene Glyceraldehyde 3 phosphate dehydrogenase 2 Neighboring gene uncharacterized protein Neighboring gene membrane steroid binding protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Ancestry of the AUTS2 family-A novel group of polycomb-complex proteins involved in human neurological disease. Sellers RA, et al. PLoS One, 2020. PMID 33306672, Free PMC Article
    2. Genome-wide association and genetic functional studies identify autism susceptibility candidate 2 gene (AUTS2) in the regulation of alcohol consumption. Schumann G, et al. Proc Natl Acad Sci U S A, 2011 Apr 26. PMID 21471458, Free PMC Article
    3. Visual targeting of motor actions in climbing Drosophila. Triphan T, et al. Curr Biol, 2010 Apr 13. PMID 20346674
    4. Locomotor control by the central complex in Drosophila-An analysis of the tay bridge mutant. Poeck B, et al. Dev Neurobiol, 2008 Jul. PMID 18446784
    5. New Insights from Drosophila into the Regulation of EGFR Signaling. Harden N. Methods Mol Biol, 2017. PMID 28791632

    See all (43) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Process Evidence Code Pubs
    involved_in adult walking behavior IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in imaginal disc-derived wing vein morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of epidermal growth factor receptor signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in negative regulation of epidermal growth factor receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in pattern orientation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    tay bridge
    Names
    CG9056-PA
    CG9056-PB
    CG9056-PC
    CG9056-PD
    Tay bridge
    lethal (1) 14Ac
    tay-PA
    tay-PB
    tay-PC
    tay-PD

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      15876368..15887311 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001272656.2 → NP_001259585.1  tay bridge, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001259585.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8MSW7, Q9VXM5
      Conserved Domains (1) summary
      pfam15336
      Location:1900 → 1922
      Auts2; Autism susceptibility gene 2 protein

    2. NM_001272657.2 → NP_001259586.1  tay bridge, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001259586.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8MSW7, Q9VXM5
      Conserved Domains (1) summary
      pfam15336
      Location:1900 → 1922
      Auts2; Autism susceptibility gene 2 protein

    3. NM_001298376.1 → NP_001285305.1  tay bridge, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001285305.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      X2JC54
      Conserved Domains (1) summary
      pfam15336
      Location:1899 → 1921
      Auts2; Autism susceptibility gene 2 protein

    4. NM_132858.3 → NP_573086.2  tay bridge, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_573086.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8MSW7, Q9VXM5
      Related
      FBpp0073960
      Conserved Domains (1) summary
      pfam15336
      Location:1900 → 1922
      Auts2; Autism susceptibility gene 2 protein
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VXM5 Q9VXM5
    X2JC54 X2JC54

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