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    pita pita [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 37730, updated on 17-Dec-2024

    Summary

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    Official Symbol
    pitaprovided by FlyBase
    Official Full Name
    pitaprovided by FlyBase
    Primary source
    FLYBASE:FBgn0034878
    Locus tag
    Dmel_CG3941
    See related
    AllianceGenome:FB:FBgn0034878
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG3941; Dmel\CG3941; Pita; PITA; spdk
    Summary
    Enables chromatin insulator sequence binding activity and sequence-specific DNA binding activity. Involved in DNA endoreduplication and regulation of DNA-templated transcription. Located in nucleus and polytene chromosome. Is expressed in several structures, including CNS glial cell; ganglia; head epidermis primordium; somatic precursor cell; and unpaired neurons. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See pita in Genome Data Viewer
    Location:
    59E3-59E3; 2-103 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (23548967..23554712, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (19436490..19442235, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Gustatory receptor 59f Neighboring gene aaRS-interacting multifunctional protein 3 Neighboring gene wing morphogenesis defect Neighboring gene levy Neighboring gene Death caspase-1 Neighboring gene Rrp4 Neighboring gene Integrin alphaPS5 subunit

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Morphological irregularities and features of resistance to apoptosis in the dcp-1/pita double mutated egg chambers during Drosophila oogenesis. Nezis IP, et al. Cell Motil Cytoskeleton, 2005 Jan. PMID 15547953
    2. Germline cell death is inhibited by P-element insertions disrupting the dcp-1/pita nested gene pair in Drosophila. Laundrie B, et al. Genetics, 2003 Dec. PMID 14704173, Free PMC Article
    3. Redundant enhancers in the iab-5 domain cooperatively activate Abd-B in the A5 and A6 abdominal segments of Drosophila. Postika N, et al. Development, 2021 Oct 1. PMID 34473267, Free PMC Article
    4. Architectural protein Pita cooperates with dCTCF in organization of functional boundaries in Bithorax complex. Kyrchanova O, et al. Development, 2017 Jul 15. PMID 28619827, Free PMC Article
    5. Lineage-specific expansion of the zinc finger associated domain ZAD. Chung HR, et al. Mol Biol Evol, 2007 Sep. PMID 17569752

    See all (82) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Mechanism and functional role of the interaction between CP190 and the architectural protein Pita in Drosophila melanogaster.
      Title: Mechanism and functional role of the interaction between CP190 and the architectural protein Pita in Drosophila melanogaster.
    2. Mutation of the Mcp Pita site disrupts blocking activity and also eliminates dCTCF binding. In contrast, mutation of the Mcp dCTCF site does not affect Pita binding, and this mutant boundary retains partial function.
      Title: Architectural protein Pita cooperates with dCTCF in organization of functional boundaries in Bithorax complex.
    3. Here we have shown that the ZAD domains of ZIPIC, Pita and Zw5 form homodimers. In Drosophila transgenic lines, these proteins are able to support long-distance interaction between GAL4 activator and the reporter gene promoter.
      Title: Architectural proteins Pita, Zw5,and ZIPIC contain homodimerization domain and support specific long-range interactions in Drosophila.
    4. Model binding sites for Pita or ZIPIC demonstrate a partial enhancer-blocking activity and protect gene expression from PRE-mediated silencing.
      Title: Two new insulator proteins, Pita and ZIPIC, target CP190 to chromatin.
    5. novel characteristic morphological features of egg chambers lacking both dcp-1 and pita functions in the germline cells; suggested an essential role of dcp-1 and/or pita during mid-oogenesis
      Title: Morphological irregularities and features of resistance to apoptosis in the dcp-1/pita double mutated egg chambers during Drosophila oogenesis.
    6. Spotted-dick is a zinc-finger protein of Drosophila required for expression of Orc4 and S phase.
      Title: Spotted-dick, a zinc-finger protein of Drosophila required for expression of Orc4 and S phase.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables DNA-binding transcription factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables chromatin binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables chromatin insulator sequence binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA endoreduplication IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in DNA replication IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of DNA-templated transcription IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in polytene chromosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    pita
    Names
    CG3941-PA
    CG3941-PB
    pita-PA
    pita-PB
    spotted dick

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      23548967..23554712 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_137962.3 → NP_611806.3  pita, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_611806.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q95RQ8, Q9W1N1
      Related
      FBpp0072021
      Conserved Domains (6) summary
      smart00868
      Location:17 → 92
      zf-AD; Zinc-finger associated domain (zf-AD)
      COG5048
      Location:281 → 506
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:288 → 308
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:372 → 388
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:328 → 353
      zf-H2C2_2; Zinc-finger double domain
      cl01319
      Location:566 → 625
      HARE-HTH; HB1, ASXL, restriction endonuclease HTH domain

    2. NM_166607.2 → NP_726339.2  pita, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_726339.2

      Status: REVIEWED

      Related
      FBpp0072022
      Conserved Domains (5) summary
      COG5048
      Location:221 → 446
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:228 → 248
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam07776
      Location:1 → 33
      zf-AD; Zinc-finger associated domain (zf-AD)
      pfam13465
      Location:268 → 293
      zf-H2C2_2; Zinc-finger double domain
      cl01319
      Location:506 → 565
      HARE-HTH; HB1, ASXL, restriction endonuclease HTH domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q95RQ8 Q95RQ8
    Q95RQ8.1
    Q9W1N1 Q9W1N1

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