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    Patronin patronin [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 36978, updated on 9-Dec-2024

    Summary

    Official Symbol
    Patroninprovided by FlyBase
    Official Full Name
    patroninprovided by FlyBase
    Primary source
    FLYBASE:FBgn0263197
    Locus tag
    Dmel_CG33130
    See related
    AllianceGenome:FB:FBgn0263197
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BcDNA:LD17191; CG18459; CG18460; CG18462; CG30102; CG33130; CG6516; Dmel\CG33130; l(2)k07433; Patr; patronin; ptrn; ssp4; Ssp4
    Summary
    Enables microtubule minus-end binding activity. Involved in several processes, including asymmetric protein localization involved in cell fate determination; microtubule cytoskeleton organization; and negative regulation of hippo signaling. Located in several cellular components, including anterior cell cortex; microtubule cytoskeleton; and subapical part of cell. Is expressed in adult head; embryonic/larval dorsal vessel; organism; and spermatozoon. Human ortholog(s) of this gene implicated in complex cortical dysplasia with other brain malformations. Orthologous to several human genes including CAMSAP1 (calmodulin regulated spectrin associated protein 1) and CAMSAP2 (calmodulin regulated spectrin associated protein family member 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Patronin in Genome Data Viewer
    Location:
    54C1-54C3; 2-83 cM
    Exon count:
    24
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (17519024..17535866, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (13406529..13423371, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Cathepsin K2 Neighboring gene uncharacterized protein Neighboring gene Anaphase Promoting Complex subunit 10 Neighboring gene uncharacterized protein Neighboring gene eukaryotic translation initiation factor 3 subunit b Neighboring gene Coiled-coil and C2 domain containing 2A Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables calmodulin binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables microtubule binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables microtubule binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    enables microtubule minus-end binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables microtubule minus-end binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables microtubule minus-end binding IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables spectrin binding IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in anterior cell cortex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in centrosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in lateral cell cortex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in microtubule IDA
    Inferred from Direct Assay
    more info
    PubMed 
    colocalizes_with microtubule minus-end IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in midbody IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in mitotic spindle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in spindle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in subapical part of cell IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    patronin
    Names
    CG33130-PA
    CG33130-PB
    CG33130-PC
    CG33130-PD
    CG33130-PE
    CG33130-PF
    CG33130-PI
    CG33130-PJ
    CG33130-PK
    CG33130-PL
    CG33130-PM
    CG33130-PN
    CG33130-PO
    Patronin-PA
    Patronin-PB
    Patronin-PC
    Patronin-PD
    Patronin-PE
    Patronin-PF
    Patronin-PI
    Patronin-PJ
    Patronin-PK
    Patronin-PL
    Patronin-PM
    Patronin-PN
    Patronin-PO
    lethal (2) k07433
    short spindle 4

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      17519024..17535866 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001274127.1NP_001261056.1  patronin, isoform N [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001261056.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4KEY6, A0A0U3DWR7
      Conserved Domains (4) summary
      TIGR02794
      Location:10501170
      tolA_full; TolA protein
      pfam08683
      Location:12991417
      CAMSAP_CKK; Microtubule-binding calmodulin-regulated spectrin-associated
      pfam11971
      Location:188267
      CAMSAP_CH; CAMSAP CH domain
      pfam17095
      Location:474540
      CAMSAP_CC1; Spectrin-binding region of Ca2+-Calmodulin
    2. NM_001144218.3NP_001137690.1  patronin, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001137690.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      B7YZJ1, H6WS59
      Conserved Domains (4) summary
      TIGR02794
      Location:12501370
      tolA_full; TolA protein
      pfam08683
      Location:15231641
      CAMSAP_CKK; Microtubule-binding calmodulin-regulated spectrin-associated
      pfam11971
      Location:189272
      CAMSAP_CH; CAMSAP CH domain
      pfam17095
      Location:591658
      CAMSAP_CC1; Spectrin-binding region of Ca2+-Calmodulin
    3. NM_001274125.1NP_001261054.1  patronin, isoform L [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001261054.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4KG58, H6WS59
      Conserved Domains (4) summary
      TIGR02794
      Location:11861306
      tolA_full; TolA protein
      pfam08683
      Location:13981516
      CAMSAP_CKK; Microtubule-binding calmodulin-regulated spectrin-associated
      pfam11971
      Location:189272
      CAMSAP_CH; CAMSAP CH domain
      pfam17095
      Location:577644
      CAMSAP_CC1; Spectrin-binding region of Ca2+-Calmodulin
    4. NM_206153.3NP_995875.1  patronin, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_995875.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A1ZAU8, A1ZAU9, A1ZAV0, Q86NU5, Q8MSU7
      UniProtKB/TrEMBL
      H6WS59
      Conserved Domains (4) summary
      TIGR02794
      Location:12171337
      tolA_full; TolA protein
      pfam08683
      Location:14901608
      CAMSAP_CKK; Microtubule-binding calmodulin-regulated spectrin-associated
      pfam11971
      Location:189272
      CAMSAP_CH; CAMSAP CH domain
      pfam17095
      Location:591658
      CAMSAP_CC1; Spectrin-binding region of Ca2+-Calmodulin
    5. NM_001144219.3NP_001137691.1  patronin, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001137691.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      B7YZJ2, H6WS59
      Conserved Domains (4) summary
      TIGR02794
      Location:12711391
      tolA_full; TolA protein
      pfam08683
      Location:14591577
      CAMSAP_CKK; Microtubule-binding calmodulin-regulated spectrin-associated
      pfam11971
      Location:189272
      CAMSAP_CH; CAMSAP CH domain
      pfam17095
      Location:612679
      CAMSAP_CC1; Spectrin-binding region of Ca2+-Calmodulin
    6. NM_001274122.1NP_001261051.1  patronin, isoform I [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001261051.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4KEY4, H6WS59
      Conserved Domains (4) summary
      TIGR02794
      Location:12711391
      tolA_full; TolA protein
      pfam08683
      Location:15491667
      CAMSAP_CKK; Microtubule-binding calmodulin-regulated spectrin-associated
      pfam11971
      Location:189272
      CAMSAP_CH; CAMSAP CH domain
      pfam17095
      Location:612679
      CAMSAP_CC1; Spectrin-binding region of Ca2+-Calmodulin
    7. NM_001169706.2NP_001163177.2  patronin, isoform O [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001163177.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      E1JH91, H6WS59
      Conserved Domains (4) summary
      TIGR02794
      Location:12711391
      tolA_full; TolA protein
      pfam08683
      Location:15431661
      CAMSAP_CKK; Microtubule-binding calmodulin-regulated spectrin-associated
      pfam11971
      Location:189272
      CAMSAP_CH; CAMSAP CH domain
      pfam17095
      Location:612679
      CAMSAP_CC1; Spectrin-binding region of Ca2+-Calmodulin
    8. NM_001169704.2NP_001163175.1  patronin, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001163175.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      E1JH90, H6WS59
      Conserved Domains (4) summary
      TIGR02794
      Location:12711391
      tolA_full; TolA protein
      pfam08683
      Location:15311649
      CAMSAP_CKK; Microtubule-binding calmodulin-regulated spectrin-associated
      pfam11971
      Location:189272
      CAMSAP_CH; CAMSAP CH domain
      pfam17095
      Location:612679
      CAMSAP_CC1; Spectrin-binding region of Ca2+-Calmodulin
    9. NM_001274126.1NP_001261055.1  patronin, isoform M [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001261055.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4KFU3, A0A0U3DWR7
      Conserved Domains (4) summary
      TIGR02794
      Location:11401260
      tolA_full; TolA protein
      pfam08683
      Location:13641482
      CAMSAP_CKK; Microtubule-binding calmodulin-regulated spectrin-associated
      pfam11971
      Location:189272
      CAMSAP_CH; CAMSAP CH domain
      pfam17095
      Location:530597
      CAMSAP_CC1; Spectrin-binding region of Ca2+-Calmodulin
    10. NM_001274124.1NP_001261053.1  patronin, isoform K [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001261053.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4KFA4, H6WS59
      Conserved Domains (4) summary
      TIGR02794
      Location:12871407
      tolA_full; TolA protein
      pfam08683
      Location:15401658
      CAMSAP_CKK; Microtubule-binding calmodulin-regulated spectrin-associated
      pfam11971
      Location:189272
      CAMSAP_CH; CAMSAP CH domain
      pfam17095
      Location:628695
      CAMSAP_CC1; Spectrin-binding region of Ca2+-Calmodulin
    11. NM_001274123.1NP_001261052.1  patronin, isoform J [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001261052.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4KET5, H6WS59
      Conserved Domains (4) summary
      TIGR02794
      Location:13211441
      tolA_full; TolA protein
      pfam08683
      Location:15341652
      CAMSAP_CKK; Microtubule-binding calmodulin-regulated spectrin-associated
      pfam11971
      Location:189272
      CAMSAP_CH; CAMSAP CH domain
      pfam17095
      Location:663730
      CAMSAP_CC1; Spectrin-binding region of Ca2+-Calmodulin
    12. NM_206154.3NP_995876.1  patronin, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_995876.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      H6WS59
      Conserved Domains (4) summary
      TIGR02794
      Location:11891309
      tolA_full; TolA protein
      pfam08683
      Location:14001518
      CAMSAP_CKK; Microtubule-binding calmodulin-regulated spectrin-associated
      pfam11971
      Location:189272
      CAMSAP_CH; CAMSAP CH domain
      pfam17095
      Location:612679
      CAMSAP_CC1; Spectrin-binding region of Ca2+-Calmodulin
    13. NM_176218.3NP_788398.1  patronin, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_788398.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0U3DWR7
      Related
      FBpp0086104
      Conserved Domains (4) summary
      TIGR02794
      Location:11891309
      tolA_full; TolA protein
      pfam08683
      Location:13771495
      CAMSAP_CKK; Microtubule-binding calmodulin-regulated spectrin-associated
      pfam11971
      Location:189272
      CAMSAP_CH; CAMSAP CH domain
      pfam17095
      Location:612679
      CAMSAP_CC1; Spectrin-binding region of Ca2+-Calmodulin