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    AIMP2 aaRS-interacting multifunctional protein 2 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 39690, updated on 9-Dec-2024

    Summary

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    Official Symbol
    AIMP2provided by FlyBase
    Official Full Name
    aaRS-interacting multifunctional protein 2provided by FlyBase
    Primary source
    FLYBASE:FBgn0036515
    Locus tag
    Dmel_CG12304
    See related
    AllianceGenome:FB:FBgn0036515
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG12304; Dmel\CG12304; p38
    Summary
    Predicted to be part of aminoacyl-tRNA synthetase multienzyme complex. Is expressed in several structures, including adult head; anterior endoderm; embryonic/larval midgut primordium; gut section; and mesoderm. Human ortholog(s) of this gene implicated in hypomyelinating leukodystrophy 17. Orthologous to human AIMP2 (aminoacyl tRNA synthetase complex interacting multifunctional protein 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See AIMP2 in Genome Data Viewer
    Location:
    71E1-71E1; 3-43 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (15583638..15585347)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (15576738..15578447)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene marionette Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Rho GTPase activating protein at 71E Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The 18S ribosomal RNA m(6) A methyltransferase Mettl5 is required for normal walking behavior in Drosophila. Leismann J, et al. EMBO Rep, 2020 Jul 3. PMID 32350990, Free PMC Article
    2. The aminoacyl-tRNA synthetases of Drosophila melanogaster. Lu J, et al. Fly (Austin), 2015. PMID 26761199, Free PMC Article
    3. Identification of a novel class of insect glutathione S-transferases involved in resistance to DDT in the malaria vector Anopheles gambiae. Ranson H, et al. Biochem J, 2001 Oct 15. PMID 11583575, Free PMC Article
    4. Genetic and proteomic evidence for roles of Drosophila SUMO in cell cycle control, Ras signaling, and early pattern formation. Nie M, et al. PLoS One, 2009 Jun 16. PMID 19529778, Free PMC Article
    5. Discovery and Visualization of Age-Dependent Patterns in the Diurnal Transcriptome of Drosophila. Sebastian B, et al. J Circadian Rhythms, 2022. PMID 36561348, Free PMC Article

    See all (33) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    part_of aminoacyl-tRNA synthetase multienzyme complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of aminoacyl-tRNA synthetase multienzyme complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    aaRS-interacting multifunctional protein 2
    Names
    AIMP2-PA
    AIMP2-PB
    CG12304-PA
    CG12304-PB
    aminoacyl-tRNA synthetase-interacting multifunctional protein 2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      15583638..15585347
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_140525.4 → NP_648782.2  aaRS-interacting multifunctional protein 2, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_648782.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9VUR3
      UniProtKB/TrEMBL
      E4NKL6
      Related
      FBpp0075318
      Conserved Domains (1) summary
      cd00299
      Location:275 → 327
      GST_C_family; C-terminal, alpha helical domain of the Glutathione S-transferase family

    2. NM_206375.3 → NP_996097.1  aaRS-interacting multifunctional protein 2, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_996097.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q6NKM4, Q7KUM5, Q8T060
      Conserved Domains (1) summary
      cd00299
      Location:242 → 294
      GST_C_family; C-terminal, alpha helical domain of the Glutathione S-transferase family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8T060 Q8T060
    Q9VUR3.1 Q9VUR3

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