Stat92E Signal-transducer and activator of transcription protein at 92E [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Stat92Eprovided by FlyBase
Official Full Name: Signal-transducer and activator of transcription protein at 92Eprovided by FlyBase
Primary source: FLYBASE:FBgn0016917
Locus tag: Dmel_CG4257
See related: AllianceGenome:FB:FBgn0016917
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG4257; d-STAT; D-stat; D-Stat; D-STAT; D-stat/stat92E; Dmel\CG4257; DmSTAT; DRODSRC; DSRC; Dst; dstat; dSTAT; Dstat; DSTAT; Dstat 92E; dSTAT92E; Dstat92E; dSTAT92E/marelle; l(3)06346; l(3)j6C8; mrl; mrL; mrl stat92E; pSTAT; pSTAT92E; SD-stat; Sta92E; stat; Stat; STAT; STAT 92E; Stat1alpha-like; stat92; Stat92; STAT92; stat92e; stat92E; Stat92e; STAT92e; STAT92E; Stat9E; stat[92E]
Summary: Enables several functions, including DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and histone binding activity. Involved in several processes, including larval development; oogenesis; and regionalization. Located in cytoplasmic side of apical plasma membrane; cytosol; and nucleus. Is expressed in several structures, including follicle cell; germline cell; gut section; head epidermis primordium; and somatic cell of testis. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); breast cancer (multiple); carcinoma (multiple); reproductive organ cancer (multiple); and scleroderma (multiple). Orthologous to several human genes including STAT5A (signal transducer and activator of transcription 5A) and STAT5B (signal transducer and activator of transcription 5B). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 92F1-92F1; 3-69 cM

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3R	NT_033777.3 (20535323..20552311, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3R	NT_033777.2 (16361045..16378033, complement)

Chromosome 3R - NT_033777.3 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Experimental validation and characterization of putative targets of Escargot and STAT, two master regulators of the intestinal stem cells in Drosophila melanogaster.
Title: Experimental validation and characterization of putative targets of Escargot and STAT, two master regulators of the intestinal stem cells in Drosophila melanogaster.
We further identify Upd2 as an activating ligand for JAK/STAT activity in the ASP. Together, these data constitute a considerable step forward in understanding the role of JAK/STAT signaling in ASPs and similar structures in mammalian models
Title: JAK/STAT signaling is involved in air sac primordium development of Drosophila melanogaster.
Thus, CtBP stabilizes cell fates following damage by opposing the destabilizing effects of the JNK/AP-1 and JAK/STAT pathways.
Title: CtBP impedes JNK- and Upd/STAT-driven cell fate misspecifications in regenerating Drosophila imaginal discs.
dIAP1 and Cyclin A have been identified as two critical genes regulated by JAK/STAT and contributing to the growth of the Hedgehog-expressing cell population in Drosophila wing morphogenesis.
Title: JAK/STAT controls organ size and fate specification by regulating morphogen production and signalling.
Cell fusion during wound healing in Drosophila larval epidermis occurred primarily in the wound vicinity, where JAK/STAT activation was suppressed by fusion-inducing JNK signaling.
Title: Spatiotemporal regulation of cell fusion by JNK and JAK/STAT signaling during Drosophila wound healing.
Data show that JNK signalling inhibits the growth of losers, while JAK/STAT signalling promotes competition-induced winner cell proliferation.
Title: Chronic activation of JNK JAK/STAT and oxidative stress signalling causes the loser cell status.
Examination of the epistatic relationship between candidate genes and Stat92E reveals that Ptp61F and brm interact with Stat92E during both border cell specification and migration.
Title: Identification of Novel Regulators of the JAK/STAT Signaling Pathway that Control Border Cell Migration in the Drosophila Ovary.
The current study further solidified the role of STAT and Wg in regeneration, by identifying their contribution to abnormal regenerations induced by IR. STAT92E (Drosophila STAT3/5) and Nurf-38, which encodes a member of the Nucleosome Remodeling Factor complex, oppose each other in these cells to modulate the frequency of ectopic disc growth
Title: STAT, Wingless, and Nurf-38 determine the accuracy of regeneration after radiation damage in Drosophila.
Resistance to ionizing radiation-induced apoptosis requires STAT and Wg and is mediated by transcriptional repression of the pro-apoptotic gene reaper.
Title: Drosophila Wnt and STAT Define Apoptosis-Resistant Epithelial Cells for Tissue Regeneration after Irradiation.
critical in vivo regulator of glial responsiveness to axonal injury
Title: PI3K signaling and Stat92E converge to modulate glial responsiveness to axonal injury.

Submit: New GeneRIF Correction See all GeneRIFs (54)

Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

mobile_element

Loc: c20547573-20547512 mobile_element_type = transposon:INE-1{}5822

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA binding	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IGI Inferred from Genetic Interaction more info	PubMed
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IMP Inferred from Mutant Phenotype more info	PubMed
enables DNA-binding transcription factor activity	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables cytokine receptor binding	IPI Inferred from Physical Interaction more info	PubMed
enables histone binding	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in antiviral innate immune response	IDA Inferred from Direct Assay more info	PubMed
involved_in blastoderm segmentation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in border follicle cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell dedifferentiation	IEP Inferred from Expression Pattern more info	PubMed
involved_in cell surface receptor signaling pathway via JAK-STAT	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell surface receptor signaling pathway via JAK-STAT	IDA Inferred from Direct Assay more info	PubMed
involved_in cell surface receptor signaling pathway via JAK-STAT	IGI Inferred from Genetic Interaction more info	PubMed
involved_in cell surface receptor signaling pathway via JAK-STAT	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell surface receptor signaling pathway via STAT	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to X-ray	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to lipopolysaccharide	IDA Inferred from Direct Assay more info	PubMed
involved_in defense response	IBA Inferred from Biological aspect of Ancestor more info
involved_in defense response	IDA Inferred from Direct Assay more info	PubMed
involved_in determination of digestive tract left/right asymmetry	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in eye-antennal disc morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in follicle cell of egg chamber stalk formation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in germ-line stem cell population maintenance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in hindgut morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in intestinal stem cell homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in lamellocyte differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in larval lymph gland hemopoiesis	IGI Inferred from Genetic Interaction more info	PubMed
involved_in larval lymph gland hemopoiesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in larval somatic muscle development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in long-term memory	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in lymph gland development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in male germ-line sex determination	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of antimicrobial humoral response	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of antimicrobial humoral response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of stem cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in nervous system development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in oocyte localization involved in germarium-derived egg chamber formation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in oogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in open tracheal system development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cell population proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of defense response to virus by host	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of heterochromatin formation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in primary sex determination	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in regulation of cell population proliferation	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in segment specification	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in signal transduction	IEA Inferred from Electronic Annotation more info
involved_in stem cell division	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in stem cell population maintenance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in tissue regeneration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in wing disc morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in wound healing	IEP Inferred from Expression Pattern more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasmic side of apical plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: Signal-transducer and activator of transcription protein at 92E

Names: CG4257-PB; CG4257-PC; CG4257-PE; CG4257-PF; CG4257-PG; CG4257-PH; CG4257-PI; CG4257-PJ; CG4257-PK; CG4257-PL; CG4257-PM; Signal-transducer and activator of transcription protein; Stat92E-PB; Stat92E-PC; Stat92E-PE; Stat92E-PF; Stat92E-PG; Stat92E-PH; Stat92E-PI; Stat92E-PJ; Stat92E-PK; Stat92E-PL; Stat92E-PM; marelle; signal transducer and activator of transcription; signal transducers and activator of transcription; stat92E

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033777.3 Reference assembly

Range

20535323..20552311 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001275828.1 → NP_001262757.1 Signal-transducer and activator of transcription protein at 92E, isoform H [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001262757.1

Status: REVIEWED

UniProtKB/TrEMBL

A0A0B4KHS6

Conserved Domains (3) summary

cd09919
Location:452 → 570

SH2_STAT_family; Src homology 2 (SH2) domain found in signal transducer and activator of transcription (STAT) family

pfam01017
Location:25 → 214

STAT_alpha; STAT protein, all-alpha domain

pfam02864
Location:216 → 461

STAT_bind; STAT protein, DNA binding domain
NM_206520.2 → NP_996242.1 Signal-transducer and activator of transcription protein at 92E, isoform E [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_996242.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q24151

Conserved Domains (4) summary

cd09919
Location:578 → 696

SH2_STAT_family; Src homology 2 (SH2) domain found in signal transducer and activator of transcription (STAT) family

pfam01017
Location:151 → 340

STAT_alpha; STAT protein, all-alpha domain

pfam02864
Location:342 → 587

STAT_bind; STAT protein, DNA binding domain

cl03749
Location:2 → 119

STAT_int; STAT protein, protein interaction domain
NM_001275830.1 → NP_001262759.1 Signal-transducer and activator of transcription protein at 92E, isoform J [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001262759.1

Status: REVIEWED

UniProtKB/TrEMBL

A0A0B4KGI7

Conserved Domains (4) summary

cd09919
Location:578 → 696

SH2_STAT_family; Src homology 2 (SH2) domain found in signal transducer and activator of transcription (STAT) family

smart00964
Location:2 → 119

STAT_int; STAT protein, protein interaction domain

pfam01017
Location:151 → 340

STAT_alpha; STAT protein, all-alpha domain

pfam02864
Location:342 → 587

STAT_bind; STAT protein, DNA binding domain
NM_206521.2 → NP_996243.1 Signal-transducer and activator of transcription protein at 92E, isoform F [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_996243.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q0KI43, Q24151, Q24181, Q59DV7, Q5BIB0, Q8IN54, Q8SX55, Q9VDL8

UniProtKB/TrEMBL

A0A0B4KHS7

Conserved Domains (4) summary

cd09919
Location:578 → 696

SH2_STAT_family; Src homology 2 (SH2) domain found in signal transducer and activator of transcription (STAT) family

pfam01017
Location:151 → 340

STAT_alpha; STAT protein, all-alpha domain

pfam02864
Location:342 → 587

STAT_bind; STAT protein, DNA binding domain

cl03749
Location:2 → 119

STAT_int; STAT protein, protein interaction domain
NM_169900.3 → NP_732517.2 Signal-transducer and activator of transcription protein at 92E, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_732517.2

Status: REVIEWED

UniProtKB/Swiss-Prot

Q24151

Related

FBpp0088487

Conserved Domains (3) summary

cd09919
Location:452 → 570

SH2_STAT_family; Src homology 2 (SH2) domain found in signal transducer and activator of transcription (STAT) family

pfam01017
Location:25 → 214

STAT_alpha; STAT protein, all-alpha domain

pfam02864
Location:216 → 461

STAT_bind; STAT protein, DNA binding domain
NM_001014643.2 → NP_001014643.1 Signal-transducer and activator of transcription protein at 92E, isoform G [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001014643.1

Status: REVIEWED

UniProtKB/TrEMBL

A0A0B4KHS6

Conserved Domains (3) summary

cd09919
Location:452 → 570

SH2_STAT_family; Src homology 2 (SH2) domain found in signal transducer and activator of transcription (STAT) family

pfam01017
Location:25 → 214

STAT_alpha; STAT protein, all-alpha domain

pfam02864
Location:216 → 461

STAT_bind; STAT protein, DNA binding domain
NM_001275829.1 → NP_001262758.1 Signal-transducer and activator of transcription protein at 92E, isoform I [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001262758.1

Status: REVIEWED

UniProtKB/TrEMBL

A0A0B4KH10

Conserved Domains (3) summary

cd09919
Location:452 → 570

SH2_STAT_family; Src homology 2 (SH2) domain found in signal transducer and activator of transcription (STAT) family

pfam01017
Location:25 → 214

STAT_alpha; STAT protein, all-alpha domain

pfam02864
Location:216 → 461

STAT_bind; STAT protein, DNA binding domain
NM_169899.3 → NP_732516.2 Signal-transducer and activator of transcription protein at 92E, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_732516.2

Status: REVIEWED

UniProtKB/Swiss-Prot

Q24151

Related

FBpp0088488

Conserved Domains (4) summary

cd09919
Location:578 → 696

SH2_STAT_family; Src homology 2 (SH2) domain found in signal transducer and activator of transcription (STAT) family

pfam01017
Location:151 → 340

STAT_alpha; STAT protein, all-alpha domain

pfam02864
Location:342 → 587

STAT_bind; STAT protein, DNA binding domain

cl03749
Location:2 → 119

STAT_int; STAT protein, protein interaction domain
NM_001275833.1 → NP_001262762.1 Signal-transducer and activator of transcription protein at 92E, isoform M [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001262762.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q0KI43, Q24151, Q24181, Q59DV7, Q5BIB0, Q8IN54, Q8SX55, Q9VDL8

UniProtKB/TrEMBL

A0A0B4KHS7

Conserved Domains (4) summary

cd09919
Location:578 → 696

SH2_STAT_family; Src homology 2 (SH2) domain found in signal transducer and activator of transcription (STAT) family

pfam01017
Location:151 → 340

STAT_alpha; STAT protein, all-alpha domain

pfam02864
Location:342 → 587

STAT_bind; STAT protein, DNA binding domain

cl03749
Location:2 → 119

STAT_int; STAT protein, protein interaction domain
NM_001275831.1 → NP_001262760.1 Signal-transducer and activator of transcription protein at 92E, isoform K [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001262760.1

Status: REVIEWED

UniProtKB/TrEMBL

A0A0B4KGE1

Conserved Domains (4) summary

cd09919
Location:578 → 696

SH2_STAT_family; Src homology 2 (SH2) domain found in signal transducer and activator of transcription (STAT) family

smart00964
Location:2 → 119

STAT_int; STAT protein, protein interaction domain

pfam01017
Location:151 → 340

STAT_alpha; STAT protein, all-alpha domain

pfam02864
Location:342 → 587

STAT_bind; STAT protein, DNA binding domain
NM_001275832.1 → NP_001262761.1 Signal-transducer and activator of transcription protein at 92E, isoform L [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001262761.1

Status: REVIEWED

UniProtKB/TrEMBL

A0A0B4KH10

Conserved Domains (3) summary

cd09919
Location:452 → 570

SH2_STAT_family; Src homology 2 (SH2) domain found in signal transducer and activator of transcription (STAT) family

pfam01017
Location:25 → 214

STAT_alpha; STAT protein, all-alpha domain

pfam02864
Location:216 → 461

STAT_bind; STAT protein, DNA binding domain

Nucleotide		Protein
Heading	Accession and Version	Protein

Protein Accession	Links
Protein Accession	GenPept Link	UniProtKB Link
A0A0B4KGE1		A0A0B4KGE1
A0A0B4KGI7		A0A0B4KGI7
A0A0B4KH10		A0A0B4KH10
A0A0B4KHS6		A0A0B4KHS6
A0A0B4KHS7		A0A0B4KHS7
Q24151.1		Q24151