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    cac cacophony [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 32158, updated on 9-Dec-2024

    Summary

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    Official Symbol
    cacprovided by FlyBase
    Official Full Name
    cacophonyprovided by FlyBase
    Primary source
    FLYBASE:FBgn0263111
    Locus tag
    Dmel_CG43368
    See related
    AllianceGenome:FB:FBgn0263111
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    13; alpha1A; Ca-alpha1A; Cac; CAC; cac1; Cac1; cact; cactus; Cactus; can; Ca[[V]]2.1; CG1522; CG15928; CG43368; dCac1; dmca1A; Dmca1A; DMCA1A; Dmcalpha1A; Dmel\CG43368; EE171; H18; H47; l(1)11Aa; l(1)13; l(1)L13; L13; ldg; nbA; nonB; opm18; opm47; P18
    Old locus tag
    Dmel_CG1522; Dmel_CG15928
    Summary
    Enables high voltage-gated calcium channel activity and low voltage-gated calcium channel activity. Involved in several processes, including detection of light stimulus involved in visual perception; male courtship behavior, veined wing generated song production; and secretion by cell. Located in several cellular components, including apical plasma membrane; basolateral plasma membrane; and presynaptic active zone. Part of voltage-gated calcium channel complex. Is expressed in several structures, including CNS glial cell; adult head; ganglia; lamina; and motor neurons. Used to study epilepsy; familial hemiplegic migraine 1; and hereditary ataxia. Human ortholog(s) of this gene implicated in Lambert-Eaton myasthenic syndrome; developmental and epileptic encephalopathy (multiple); hereditary ataxia (multiple); and migraine (multiple). Orthologous to several human genes including CACNA1B (calcium voltage-gated channel subunit alpha1 B) and CACNA1E (calcium voltage-gated channel subunit alpha1 E). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See cac in Genome Data Viewer
    Location:
    10F7-11A1; 1-37 cM
    Exon count:
    40
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (11931280..11985087, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (11825313..11879120, complement)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR32660 Neighboring gene sclp Neighboring gene PDZ domain containing 8 Neighboring gene gastrulation-defective Neighboring gene twisted gastrulation

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A mutation which changes courtship song in Drosophila melanogaster. von Schilcher F. Behav Genet, 1977 May. PMID 405965
    2. Delayed synaptic transmission in Drosophila cacophonynull embryos. Hou J, et al. J Neurophysiol, 2008 Nov. PMID 18815348
    3. Deletion of a specific exon in the voltage-gated calcium channel gene cacophony disrupts locomotion in Drosophila larvae. Lembke KM, et al. J Exp Biol, 2019 Jan 1. PMID 30397173, Free PMC Article
    4. Mutations in and deletions of the Ca2+ channel-encoding gene cacophony, which affect courtship song in Drosophila, have novel effects on heartbeating. Ray VM, et al. J Neurogenet, 2005 Jan-Mar. PMID 16076631
    5. The Drosophila ortholog of the schizophrenia-associated CACNA1A and CACNA1B voltage-gated calcium channels regulate memory, sleep and circadian rhythms. Hidalgo S, et al. Neurobiol Dis, 2021 Jul. PMID 34015490

    See all (339) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The Drosophila ortholog of the schizophrenia-associated CACNA1A and CACNA1B voltage-gated calcium channels regulate memory, sleep and circadian rhythms.
      Title: The Drosophila ortholog of the schizophrenia-associated CACNA1A and CACNA1B voltage-gated calcium channels regulate memory, sleep and circadian rhythms.
    2. Separation of presynaptic Cav2 and Cav1 channel function in synaptic vesicle exo- and endocytosis by the membrane anchored Ca(2+) pump PMCA.
      Title: Separation of presynaptic Ca(v)2 and Ca(v)1 channel function in synaptic vesicle exo- and endocytosis by the membrane anchored Ca(2+) pump PMCA.
    3. Juvenile hormone drives the maturation of spontaneous mushroom body neural activity and learned behavior.
      Title: Juvenile hormone drives the maturation of spontaneous mushroom body neural activity and learned behavior.
    4. Deletion of exon 7 caused a decrease in cacophony protein expression but not total transcript levels, caused reduced locomotory activity in adults, and locomotion defects in third instar larvae.
      Title: Deletion of a specific exon in the voltage-gated calcium channel gene cacophony disrupts locomotion in Drosophila larvae.
    5. Study finds that the abundance of endogenous Cac is modulated during presynaptic homeostatic potentiation, but does not change during presynaptic homeostatic depression.
      Title: Endogenous Tagging Reveals Differential Regulation of Ca(2+) Channels at Single Active Zones during Presynaptic Homeostatic Potentiation and Depression.
    6. Strikingly the absence of any of DLG proteins at the presynaptic terminal disrupts the clustering and localization of the calcium channel DmCa1A subunit (Cacophony), decreases the action potential-evoked release probability and alters short-term plasticity.
      Title: Presynaptic DLG regulates synaptic function through the localization of voltage-activated Ca(2+) Channels.
    7. Motor defects in TDP-43 mutants can be rescued by expression of cacophony in motor neurons and by expression in two pairs of neurons in the brain.
      Title: Restoration of Motor Defects Caused by Loss of Drosophila TDP-43 by Expression of the Voltage-Gated Calcium Channel, Cacophony, in Central Neurons.
    8. the novel R1673P allele of CACNA1A produces neurodegenerative phenotypes in flies and human, likely due to a toxic gain of function
      Title: Clinically severe CACNA1A alleles affect synaptic function and neurodegeneration differentially.
    9. cacophony (cacTS2), a mutation of the Drosophila presynaptic Ca++ channel alpha1 subunit gene, is a particularly potent seizure-suppressor mutation, reverting seizure-like phenotypes for parabss1 and other BS mutants
      Title: Mutations of the Calcium Channel Gene cacophony Suppress Seizures in Drosophila.
    10. Cac regulates lysosomal fusion with endosomes and autophagosomes and is required for neuronal homeostasis.
      Title: A voltage-gated calcium channel regulates lysosomal fusion with endosomes and autophagosomes and is required for neuronal homeostasis.
    Submit: New GeneRIF Correction See all GeneRIFs (23)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables high voltage-gated calcium channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables high voltage-gated calcium channel activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables low voltage-gated calcium channel activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables voltage-gated calcium channel activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables voltage-gated calcium channel activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables voltage-gated calcium channel activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables voltage-gated calcium channel activity NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in adult locomotory behavior IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in adult locomotory behavior IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in autophagosome maturation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in autophagy IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in calcium ion import across plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in calcium ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in calcium ion transmembrane transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in calcium ion transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in calcium ion transport NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in calcium-mediated signaling IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in chemical synaptic transmission IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in chemical synaptic transmission IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in chemical synaptic transmission IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in courtship behavior IMP
    Inferred from Mutant Phenotype
    more info
    		  
    involved_in courtship behavior NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in detection of light stimulus involved in visual perception IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in epithelial fluid transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in epithelial fluid transport IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in exocytosis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in male courtship behavior, veined wing generated song production IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in male courtship behavior, veined wing generated song production NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in male courtship behavior, veined wing generated song production TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in neuron cellular homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in neuron remodeling IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    NOT involved_in neurotransmitter secretion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in neurotransmitter secretion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in phototransduction NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in positive regulation of calcium ion transport into cytosol IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of synaptic assembly at neuromuscular junction IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of heart rate IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of membrane potential in photoreceptor cell IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in regulation of neurotransmitter secretion IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in visual behavior NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in apical plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in basolateral plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in neuromuscular junction IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    located_in presynaptic active zone IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of voltage-gated calcium channel complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of voltage-gated calcium channel complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of voltage-gated calcium channel complex IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    part_of voltage-gated calcium channel complex NAS
    Non-traceable Author Statement
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    cacophony
    Names
    CG43368-PA
    CG43368-PB
    CG43368-PC
    CG43368-PD
    CG43368-PE
    CG43368-PF
    CG43368-PG
    CG43368-PH
    CG43368-PI
    CG43368-PJ
    CG43368-PL
    CG43368-PM
    CG43368-PN
    CG43368-PO
    CG43368-PP
    CG43368-PS
    CG43368-PT
    CG43368-PU
    cac-PA
    cac-PB
    cac-PC
    cac-PD
    cac-PE
    cac-PF
    cac-PG
    cac-PH
    cac-PI
    cac-PJ
    cac-PL
    cac-PM
    cac-PN
    cac-PO
    cac-PP
    cac-PS
    cac-PT
    cac-PU
    cacaphony
    cacophany
    cactus
    calcium channel alpha1 subunit
    calcium channel alpha1 subunit, type A
    lamina-degeneration
    lethal(1)11Aa
    night blind A
    nightblind
    nightblind A
    no-on-transient B

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      11931280..11985087 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001014733.5 → NP_001014733.1  cacophony, isoform I [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001014733.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q59E52
      Conserved Domains (4) summary
      pfam00520
      Location:1112 → 1347
      Ion_trans; Ion transport protein
      pfam08763
      Location:1420 → 1494
      Ca_chan_IQ; Voltage gated calcium channel IQ domain
      pfam13136
      Location:1514 → 1667
      DUF3984; Protein of unknown function (DUF3984)
      pfam16905
      Location:1355 → 1418
      GPHH; Voltage-dependent L-type calcium channel, IQ-associated

    2. NM_206693.5 → NP_996416.1  cacophony, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_996416.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P91645
      Conserved Domains (4) summary
      pfam00520
      Location:1112 → 1348
      Ion_trans; Ion transport protein
      pfam08763
      Location:1421 → 1495
      Ca_chan_IQ; Voltage gated calcium channel IQ domain
      pfam13136
      Location:1515 → 1668
      DUF3984; Protein of unknown function (DUF3984)
      pfam16905
      Location:1356 → 1419
      GPHH; Voltage-dependent L-type calcium channel, IQ-associated

    3. NM_001258709.2 → NP_001245638.1  cacophony, isoform N [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001245638.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9NGZ9
      Conserved Domains (4) summary
      pfam00520
      Location:1218 → 1451
      Ion_trans; Ion transport protein
      pfam08763
      Location:1524 → 1598
      Ca_chan_IQ; Voltage gated calcium channel IQ domain
      pfam13136
      Location:1618 → 1771
      DUF3984; Protein of unknown function (DUF3984)
      pfam16905
      Location:1459 → 1522
      GPHH; Voltage-dependent L-type calcium channel, IQ-associated

    4. NM_206696.6 → NP_996419.1  cacophony, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_996419.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P91645
      Conserved Domains (4) summary
      pfam00520
      Location:1112 → 1345
      Ion_trans; Ion transport protein
      pfam08763
      Location:1418 → 1492
      Ca_chan_IQ; Voltage gated calcium channel IQ domain
      pfam13136
      Location:1512 → 1665
      DUF3984; Protein of unknown function (DUF3984)
      pfam16905
      Location:1353 → 1416
      GPHH; Voltage-dependent L-type calcium channel, IQ-associated

    5. NM_001370017.1 → NP_001356943.1  cacophony, isoform S [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A4D6K1U1
      Conserved Domains (3) summary
      pfam00520
      Location:1094 → 1345
      Ion_trans; Ion transport protein
      pfam08763
      Location:1418 → 1492
      Ca_chan_IQ; Voltage gated calcium channel IQ domain
      pfam16905
      Location:1346 → 1416
      GPHH; Voltage-dependent L-type calcium channel, IQ-associated

    6. NM_001370018.1 → NP_001356944.1  cacophony, isoform T [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A4D6K2Y3
      Conserved Domains (3) summary
      pfam00520
      Location:1094 → 1345
      Ion_trans; Ion transport protein
      pfam08763
      Location:1418 → 1492
      Ca_chan_IQ; Voltage gated calcium channel IQ domain
      pfam16905
      Location:1346 → 1416
      GPHH; Voltage-dependent L-type calcium channel, IQ-associated

    7. NM_001370019.1 → NP_001356945.1  cacophony, isoform U [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A4D6K2Y1
      Conserved Domains (3) summary
      pfam00520
      Location:1094 → 1345
      Ion_trans; Ion transport protein
      pfam08763
      Location:1418 → 1492
      Ca_chan_IQ; Voltage gated calcium channel IQ domain
      pfam16905
      Location:1346 → 1416
      GPHH; Voltage-dependent L-type calcium channel, IQ-associated

    8. NM_078578.5 → NP_511133.2  cacophony, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_511133.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P91645
      Related
      FBpp0298319
      Conserved Domains (4) summary
      pfam00520
      Location:1112 → 1345
      Ion_trans; Ion transport protein
      pfam08763
      Location:1418 → 1492
      Ca_chan_IQ; Voltage gated calcium channel IQ domain
      pfam13136
      Location:1512 → 1665
      DUF3984; Protein of unknown function (DUF3984)
      pfam16905
      Location:1353 → 1416
      GPHH; Voltage-dependent L-type calcium channel, IQ-associated

    9. NM_001014734.4 → NP_001014734.1  cacophony, isoform H [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001014734.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q59E53
      Conserved Domains (4) summary
      pfam00520
      Location:1112 → 1346
      Ion_trans; Ion transport protein
      pfam08763
      Location:1419 → 1493
      Ca_chan_IQ; Voltage gated calcium channel IQ domain
      pfam13136
      Location:1513 → 1666
      DUF3984; Protein of unknown function (DUF3984)
      pfam16905
      Location:1354 → 1417
      GPHH; Voltage-dependent L-type calcium channel, IQ-associated

    10. NM_001258708.2 → NP_001245637.1  cacophony, isoform M [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001245637.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9NF25
      Conserved Domains (3) summary
      pfam00520
      Location:1112 → 1347
      Ion_trans; Ion transport protein
      pfam08763
      Location:1420 → 1494
      Ca_chan_IQ; Voltage gated calcium channel IQ domain
      pfam16905
      Location:1355 → 1418
      GPHH; Voltage-dependent L-type calcium channel, IQ-associated

    11. NM_001258707.2 → NP_001245636.1  cacophony, isoform L [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001245636.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9NEE2
      Conserved Domains (4) summary
      pfam00520
      Location:1112 → 1347
      Ion_trans; Ion transport protein
      pfam08763
      Location:1420 → 1494
      Ca_chan_IQ; Voltage gated calcium channel IQ domain
      pfam13136
      Location:1590 → 1743
      DUF3984; Protein of unknown function (DUF3984)
      pfam16905
      Location:1355 → 1418
      GPHH; Voltage-dependent L-type calcium channel, IQ-associated

    12. NM_001258710.2 → NP_001245639.1  cacophony, isoform O [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001245639.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O01713, O01714, P91645, Q76NR8, Q76NR9, Q76NS0, Q9VYR8
      UniProtKB/TrEMBL
      M9NDV1
      Conserved Domains (4) summary
      pfam00520
      Location:1112 → 1348
      Ion_trans; Ion transport protein
      pfam08763
      Location:1421 → 1495
      Ca_chan_IQ; Voltage gated calcium channel IQ domain
      pfam13136
      Location:1515 → 1668
      DUF3984; Protein of unknown function (DUF3984)
      pfam16905
      Location:1356 → 1419
      GPHH; Voltage-dependent L-type calcium channel, IQ-associated

    13. NM_206695.4 → NP_996418.1  cacophony, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_996418.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P91645
      Conserved Domains (4) summary
      pfam00520
      Location:1112 → 1345
      Ion_trans; Ion transport protein
      pfam08763
      Location:1418 → 1492
      Ca_chan_IQ; Voltage gated calcium channel IQ domain
      pfam13136
      Location:1512 → 1665
      DUF3984; Protein of unknown function (DUF3984)
      pfam16905
      Location:1353 → 1416
      GPHH; Voltage-dependent L-type calcium channel, IQ-associated

    14. NM_001014735.4 → NP_001014735.1  cacophony, isoform G [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001014735.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q59E51
      Conserved Domains (4) summary
      pfam00520
      Location:1112 → 1346
      Ion_trans; Ion transport protein
      pfam08763
      Location:1419 → 1493
      Ca_chan_IQ; Voltage gated calcium channel IQ domain
      pfam13136
      Location:1513 → 1666
      DUF3984; Protein of unknown function (DUF3984)
      pfam16905
      Location:1354 → 1417
      GPHH; Voltage-dependent L-type calcium channel, IQ-associated

    15. NM_001014732.4 → NP_001014732.1  cacophony, isoform J [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001014732.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q59E50
      Conserved Domains (4) summary
      pfam00520
      Location:1112 → 1347
      Ion_trans; Ion transport protein
      pfam08763
      Location:1420 → 1494
      Ca_chan_IQ; Voltage gated calcium channel IQ domain
      pfam13136
      Location:1514 → 1667
      DUF3984; Protein of unknown function (DUF3984)
      pfam16905
      Location:1355 → 1418
      GPHH; Voltage-dependent L-type calcium channel, IQ-associated

    16. NM_206697.4 → NP_996420.1  cacophony, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_996420.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P91645
      Conserved Domains (4) summary
      pfam00520
      Location:1112 → 1345
      Ion_trans; Ion transport protein
      pfam08763
      Location:1418 → 1492
      Ca_chan_IQ; Voltage gated calcium channel IQ domain
      pfam13136
      Location:1512 → 1665
      DUF3984; Protein of unknown function (DUF3984)
      pfam16905
      Location:1353 → 1416
      GPHH; Voltage-dependent L-type calcium channel, IQ-associated

    17. NM_206694.4 → NP_996417.1  cacophony, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_996417.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O01713, O01714, P91645, Q76NR8, Q76NR9, Q76NS0, Q9VYR8
      UniProtKB/TrEMBL
      M9NDV1
      Conserved Domains (4) summary
      pfam00520
      Location:1112 → 1348
      Ion_trans; Ion transport protein
      pfam08763
      Location:1421 → 1495
      Ca_chan_IQ; Voltage gated calcium channel IQ domain
      pfam13136
      Location:1515 → 1668
      DUF3984; Protein of unknown function (DUF3984)
      pfam16905
      Location:1356 → 1419
      GPHH; Voltage-dependent L-type calcium channel, IQ-associated

    18. NM_001272548.1 → NP_001259477.1  cacophony, isoform P [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001259477.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PHD4
      Conserved Domains (4) summary
      pfam00520
      Location:1112 → 1346
      Ion_trans; Ion transport protein
      pfam08763
      Location:1419 → 1493
      Ca_chan_IQ; Voltage gated calcium channel IQ domain
      pfam13136
      Location:1533 → 1686
      DUF3984; Protein of unknown function (DUF3984)
      pfam16905
      Location:1354 → 1417
      GPHH; Voltage-dependent L-type calcium channel, IQ-associated
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A4D6K1U1 A0A4D6K1U1
    A0A4D6K2Y1 A0A4D6K2Y1
    A0A4D6K2Y3 A0A4D6K2Y3
    M9NDV1 M9NDV1
    M9NEE2 M9NEE2
    M9NF25 M9NF25
    M9NGZ9 M9NGZ9
    M9PHD4 M9PHD4
    P91645.3 P91645
    Q59E50 Q59E50
    Q59E51 Q59E51
    Q59E52 Q59E52
    Q59E53 Q59E53
    Q8MRR4 Q8MRR4

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