Mmp13 matrix metallopeptidase 13 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Mmp13provided by MGI
Official Full Name: matrix metallopeptidase 13provided by MGI
Primary source: MGI:MGI:1340026
See related: Ensembl:ENSMUSG00000050578 AllianceGenome:MGI:1340026
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Clg; Mmp1; MMP-13
Summary: This gene encodes a member of the matrix metalloproteinase family that plays a role in wound healing, skeletal development and bone remodeling. The encoded protein is activated by the removal of an N-terminal activation peptide to generate a zinc-dependent endopeptidase enzyme that can cleave various native collagens, including types I - IV, X and XIV. Mice lacking the encoded protein display profound defects in growth plate cartilage as well as a delay in the endochondral bone development. Lack of the encoded protein also impairs the wound healing process due to reduced keratinocyte migration and vascular density at the wound site. This gene is located in a cluster of other matrix metalloproteinase genes on chromosome 9. [provided by RefSeq, Jun 2015]
Expression: Biased expression in CNS E18 (RPKM 1.3), limb E14.5 (RPKM 0.9) and 13 other tissues See more
Orthologs: human all
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Genomic context

Location:: 9 A1; 9 2.46 cM

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	9	NC_000075.7 (7272514..7283333)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	9	NC_000075.6 (7272514..7283333)

Chromosome 9 - NC_000075.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Inhibiting MMP13 Attenuates Deep Vein Thrombosis in a Mouse Model by Reducing the Expression of Pdpn.
Title: Inhibiting MMP13 Attenuates Deep Vein Thrombosis in a Mouse Model by Reducing the Expression of Pdpn.
[Effects of miR-143 on the migration and invasion of osteosarcoma cells by regulating MMP-13 expression].
Title: [Effects of miR-143 on the migration and invasion of osteosarcoma cells by regulating MMP-13 expression].
MMP13 promotes the osteogenic potential of BMP9 by enhancing Wnt/beta-catenin signaling via HIF-1alpha upregulation in mouse embryonic fibroblasts.
Title: MMP13 promotes the osteogenic potential of BMP9 by enhancing Wnt/β-catenin signaling via HIF-1α upregulation in mouse embryonic fibroblasts.
Matrix Metalloproteinase-1 Expression in Fibroblasts Accelerates Dermal Aging and Promotes Papilloma Development in Mouse Skin.
Title: Matrix Metalloproteinase-1 Expression in Fibroblasts Accelerates Dermal Aging and Promotes Papilloma Development in Mouse Skin.
The Expression of MMP1 and MMP7 in Mice Liver after Exposure to Aflatoxin B1 Using Immunohistochemistry Technique.
Title: The Expression of MMP1 and MMP7 in Mice Liver after Exposure to Aflatoxin B1 Using Immunohistochemistry Technique.
MIA/CD-RAP Regulates MMP13 and Is a Potential New Disease-Modifying Target for Osteoarthritis Therapy.
Title: MIA/CD-RAP Regulates MMP13 and Is a Potential New Disease-Modifying Target for Osteoarthritis Therapy.
Genetic screening of MMP1 as a potential pathogenic gene in chronic obstructive pulmonary disease.
Title: Genetic screening of MMP1 as a potential pathogenic gene in chronic obstructive pulmonary disease.
The Role of Matrix Metalloproteinase-13 (MMP13) in TGFbeta/BMP Pathway Regulation of Fibro-Adipogenic Progenitor (FAP) Differentiation.
Title: The Role of Matrix Metalloproteinase-13 (MMP13) in TGFβ/BMP Pathway Regulation of Fibro-Adipogenic Progenitor (FAP) Differentiation.
MMP1 Overexpression Promotes Cancer Progression and Associates with Poor Outcome in Head and Neck Carcinoma.
Title: MMP1 Overexpression Promotes Cancer Progression and Associates with Poor Outcome in Head and Neck Carcinoma.
Mmp13 deletion in mesenchymal cells increases bone mass and may attenuate the cortical bone loss caused by estrogen deficiency.
Title: Mmp13 deletion in mesenchymal cells increases bone mass and may attenuate the cortical bone loss caused by estrogen deficiency.

Submit: New GeneRIF Correction See all GeneRIFs (154)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (6) 1 citation
Targeted (4) 1 citation

General gene information

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Markers

Mmp13 (e-PCR), detects polymorphism
- UniSTS:259370

Mmp13 (e-PCR), detects polymorphism
- UniSTS:498479

NoName (e-PCR)
- UniSTS:494144

NoName (e-PCR)
- UniSTS:548167

X66473 (e-PCR)
- UniSTS:163451

NoName (e-PCR)
- UniSTS:489086

Mmp13 (e-PCR), detects polymorphism
- UniSTS:265619

Mmp13 (e-PCR), detects polymorphism
- UniSTS:498392

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables calcium ion binding	ISO Inferred from Sequence Orthology more info
enables calcium ion binding	ISS Inferred from Sequence or Structural Similarity more info
enables calcium-dependent protein binding	ISO Inferred from Sequence Orthology more info
enables collagen binding	ISO Inferred from Sequence Orthology more info
enables collagen binding	ISS Inferred from Sequence or Structural Similarity more info
enables endopeptidase activity	ISO Inferred from Sequence Orthology more info
enables fibronectin binding	ISO Inferred from Sequence Orthology more info
enables low-density lipoprotein particle receptor binding	ISO Inferred from Sequence Orthology more info
enables metalloendopeptidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables metalloendopeptidase activity	IDA Inferred from Direct Assay more info	PubMed
enables metalloendopeptidase activity	ISO Inferred from Sequence Orthology more info
enables peptidase activity	IDA Inferred from Direct Assay more info	PubMed
enables zinc ion binding	ISO Inferred from Sequence Orthology more info
enables zinc ion binding	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in bone mineralization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in bone morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in bone morphogenesis	ISS Inferred from Sequence or Structural Similarity more info
involved_in collagen catabolic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within collagen catabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in collagen catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in collagen catabolic process	ISO Inferred from Sequence Orthology more info
involved_in endochondral ossification	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in extracellular matrix disassembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in extracellular matrix disassembly	ISO Inferred from Sequence Orthology more info
involved_in extracellular matrix organization	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within growth plate cartilage development	IGI Inferred from Genetic Interaction more info	PubMed
involved_in heart development	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of pancreatic trypsinogen secretion	ISO Inferred from Sequence Orthology more info
involved_in protein catabolic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within protein metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in proteolysis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to hormone	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in extracellular matrix	IEA Inferred from Electronic Annotation more info
located_in extracellular region	TAS Traceable Author Statement more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info
located_in intercellular canaliculus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: collagenase 3

Names: collagenase-1; interstitial collagenase; matrix metalloproteinase 13

NP_032633.1

EC 3.4.24.-

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_008607.2 → NP_032633.1 collagenase 3 preproprotein

See identical proteins and their annotated locations for NP_032633.1

Status: REVIEWED

Source sequence(s)

AC174457, AK150728, BC125320

Consensus CDS

CCDS22803.1

UniProtKB/Swiss-Prot

P33435

UniProtKB/TrEMBL

Q3U5R7, Q3U9V5

Related

ENSMUSP00000015394.9, ENSMUST00000015394.10

Conserved Domains (4) summary

cd00094
Location:282 → 472

HX; Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of ...

cd04278
Location:113 → 268

ZnMc_MMP; Zinc-dependent metalloprotease, matrix metalloproteinase (MMP) sub-family. MMPs are responsible for a great deal of pericellular proteolysis of extracellular matrix and cell surface molecules, playing crucial roles in morphogenesis, cell fate ...

pfam00413
Location:113 → 268

Peptidase_M10; Matrixin

pfam01471
Location:33 → 92

PG_binding_1; Putative peptidoglycan binding domain