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    ACA1_018960 papain family cysteine protease subfamily protein [ Acanthamoeba castellanii str. Neff ]

    Gene ID: 14926814, updated on 17-May-2024

    Summary

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    Gene symbol
    ACA1_018960
    Gene description
    papain family cysteine protease subfamily protein
    Locus tag
    ACA1_018960
    See related
    AmoebaDB:ACA1_018960; VEuPathDB:ACA1_018960
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Acanthamoeba castellanii str. Neff (strain: Neff, culture-collection: ATCC:30010)
    Lineage
    Eukaryota; Amoebozoa; Discosea; Longamoebia; Centramoebida; Acanthamoebidae; Acanthamoeba
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    Genomic context

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    See ACA1_018960 in Genome Data Viewer
    Location:
    chromosome: Unknown
    Exon count:
    7

    NW_004457733.1Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene lipoprotein, putative Neighboring gene uncharacterized protein Neighboring gene GTP cyclohydrolase II, putative

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NW_004457733.1

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Genome of Acanthamoeba castellanii highlights extensive lateral gene transfer and early evolution of tyrosine kinase signaling. Clarke M, et al. Genome Biol, 2013 Feb 1. PMID 23375108, Free PMC Article
    2. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables cysteine-type endopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in proteolysis involved in protein catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in extracellular space IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in lysosome IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    papain family cysteine protease subfamily protein
    XP_004358308.1
    • encoded by transcript ACA1_018960A

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NW_004457733.1 Reference assembly

      Range
      34120..35989 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_004358251.1 → XP_004358308.1  papain family cysteine protease subfamily protein [Acanthamoeba castellanii str. Neff]

      See identical proteins and their annotated locations for XP_004358308.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      L8HJH5
      Conserved Domains (2) summary
      smart00848
      Location:41 → 97
      Inhibitor_I29; Cathepsin propeptide inhibitor domain (I29)
      cd02248
      Location:134 → 348
      Peptidase_C1A; Peptidase C1A subfamily (MEROPS database nomenclature); composed of cysteine peptidases (CPs) similar to papain, including the mammalian CPs (cathepsins B, C, F, H, L, K, O, S, V, X and W). Papain is an endopeptidase with specific substrate preferences, ...
    Nucleotide Protein
    Heading Accession and Version

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