brn brainiac [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: brnprovided by FlyBase
Official Full Name: brainiacprovided by FlyBase
Primary source: FLYBASE:FBgn0000221
Locus tag: Dmel_CG4934
See related: AllianceGenome:FB:FBgn0000221
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: brc; Brn; CG4934; Dmel\CG4934; EG:EG0007.6; fs(1)107; fs(1)A107; l(1)6P6
Summary: Enables beta-1,4-mannosylglycolipid beta-1,3-N-acetylglucosaminyltransferase activity. Involved in several processes, including insect visual primordium formation; maintenance of polarity of follicular epithelium; and oogenesis. Predicted to be located in Golgi stack. Predicted to be active in Golgi membrane. Is expressed in germarium. Orthologous to several human genes including B3GNT2 (UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2); B3GNT5 (UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 5); and B3GALT5 (beta-1,3-galactosyltransferase 5). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	X	NC_004354.4 (4104342..4105791)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	X	NC_004354.3 (3998375..3999824)

Chromosome X - NC_004354.4 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

encodes a beta 1,4-mannosyltransferase predicted to form the immediate precursor glycosphingolipid substrate for brainiac
Title: Drosophila egghead encodes a beta 1,4-mannosyltransferase predicted to form the immediate precursor glycosphingolipid substrate for brainiac.
Role of brainiac as glycosyltransferase involved in glycosphingolipid synthesis
Title: The Drosophila gene brainiac encodes a glycosyltransferase putatively involved in glycosphingolipid synthesis.
Brainiac has a function as glycolipid-specific beta 1,3N-acetylglucosaminyltransferase.
Title: The Drosophila melanogaster brainiac protein is a glycolipid-specific beta 1,3N-acetylglucosaminyltransferase.
Egghead and brainiac are essential for glycosphingolipid biosynthesis
Title: Egghead and brainiac are essential for glycosphingolipid biosynthesis in vivo.

Submit: New GeneRIF Correction

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables UDP-glycosyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables beta-1,4-mannosylglycolipid beta-1,3-N-acetylglucosaminyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables hexosyltransferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in border follicle cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in follicle cell of egg chamber development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in follicle cell of egg chamber-cell adhesion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in germarium-derived egg chamber formation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in glycosphingolipid biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
involved_in insect visual primordium formation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in maintenance of polarity of follicular epithelium	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in morphogenesis of follicular epithelium	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein O-linked glycosylation	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein glycosylation	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in Golgi membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in Golgi stack	ISS Inferred from Sequence or Structural Similarity more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info