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    ndl nudel [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 38738, updated on 9-Dec-2024

    Summary

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    Official Symbol
    ndlprovided by FlyBase
    Official Full Name
    nudelprovided by FlyBase
    Primary source
    FLYBASE:FBgn0002926
    Locus tag
    Dmel_CG10129
    See related
    AllianceGenome:FB:FBgn0002926
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG10129; Dmel\CG10129; mat(3)2; mel(3)5; Ndl; nud; SP89
    Summary
    Enables serine-type endopeptidase activity. Involved in several processes, including egg activation; egg chorion assembly; and protein maturation. Located in perivitelline space. Is expressed in follicle cell and ovary. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See ndl in Genome Data Viewer
    Location:
    65B5-65B5; 3-17 cM
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (6593938..6603366, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (6587038..6596466, complement)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene sulfateless Neighboring gene long non-coding RNA:CR46500 Neighboring gene Mitochondrial calcium uniporter Neighboring gene javelin Neighboring gene long non-coding RNA:CR45418 Neighboring gene RNA exonuclease 5 Neighboring gene zero population growth

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The maternal nudel protein of Drosophila has two distinct roles important for embryogenesis. Hong CC, et al. Genetics, 1996 Aug. PMID 8844153, Free PMC Article
    2. Biochemical defects of mutant nudel alleles causing early developmental arrest or dorsalization of the Drosophila embryo. LeMosy EK, et al. Genetics, 2000 Jan. PMID 10628985, Free PMC Article
    3. Evidence for a glycosaminoglycan on the nudel protein important for dorsoventral patterning of the drosophila embryo. Turcotte CL, et al. Dev Dyn, 2002 May. PMID 11984873
    4. Three-dimensional models of proteases involved in patterning of the Drosophila Embryo. Crucial role of predicted cation binding sites. Rose T, et al. J Biol Chem, 2003 Mar 28. PMID 12493753
    5. Activation of Snake in a serine protease cascade that defines the dorsoventral axis is atypical and pipe-independent in Drosophila embryos. Steen PW, et al. FEBS Lett, 2010 Aug 20. PMID 20638387, Free PMC Article

    See all (119) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. proteolytically processed segments of Nudel are secreted into the perivitelline space; however, there is no requirement for nudel to be expressed in ventral, pipe-expressing follicle cells
      Title: No requirement for localized Nudel protein expression in Drosophila embryonic axis determination.
    2. Data show that the N-terminal region of Nudel contains a site for glycosaminoglycan (GAG) attachment that is required for dorsoventral patterning.
      Title: Evidence for a glycosaminoglycan on the nudel protein important for dorsoventral patterning of the drosophila embryo.
    3. provision of three-dimensional model and role of cation binding sites in embryo patterning
      Title: Three-dimensional models of proteases involved in patterning of the Drosophila Embryo. Crucial role of predicted cation binding sites.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables serine-type endopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables serine-type endopeptidase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables serine-type endopeptidase activity ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in Toll receptor ligand protein activation cascade IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in Toll receptor ligand protein activation cascade IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in dorsal/ventral axis specification IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in dorsal/ventral axis specification IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in egg activation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in egg chorion assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein autoprocessing IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein processing IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in proteolysis ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    involved_in zymogen activation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in extracellular region IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in perivitelline space IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    nudel
    Names
    CG10129-PA
    ndl-PA
    NP_523947.2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      6593938..6603366 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_079223.2 → NP_523947.2  nudel [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_523947.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P98159, Q9VRX5
      Related
      FBpp0076693, FBtr0076984
      Conserved Domains (6) summary
      pfam09595
      Location:1448 → 1600
      Metaviral_G; Metaviral_G glycoprotein
      smart00192
      Location:2350 → 2383
      LDLa; Low-density lipoprotein receptor domain class A
      smart00020
      Location:1144 → 1377
      Tryp_SPc; Trypsin-like serine protease
      cd00112
      Location:2421 → 2457
      LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
      cd00190
      Location:1145 → 1379
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
      pfam09342
      Location:2041 → 2158
      DUF1986; Domain of unknown function (DUF1986)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P98159.2 P98159

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