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    Traf5 TNF receptor-associated factor 5 [ Mus musculus (house mouse) ]

    Gene ID: 22033, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Traf5provided by MGI
    Official Full Name
    TNF receptor-associated factor 5provided by MGI
    Primary source
    MGI:MGI:107548
    See related
    Ensembl:ENSMUSG00000026637 AllianceGenome:MGI:107548
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Predicted to enable enzyme binding activity; identical protein binding activity; and signaling adaptor activity. Involved in interleukin-17-mediated signaling pathway and regulation of gene expression. Acts upstream of or within positive regulation of cell population proliferation and signal transduction. Located in cytoplasmic side of plasma membrane. Part of CD40 receptor complex. Is expressed in genitourinary system and tongue muscle. Orthologous to human TRAF5 (TNF receptor associated factor 5). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in spleen adult (RPKM 10.1), bladder adult (RPKM 8.7) and 25 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Traf5 in Genome Data Viewer
    Location:
    1 H6; 1 97.11 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (191729164..191776899, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (191997203..192092599, complement)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_03447 Neighboring gene predicted gene, 39743 Neighboring gene retinal degeneration 3 Neighboring gene STARR-positive B cell enhancer ABC_E4410 Neighboring gene predicted gene, 32460 Neighboring gene microRNA 3473c Neighboring gene glutathione S-transferase, pi, pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E11114 Neighboring gene STARR-positive B cell enhancer ABC_E11115 Neighboring gene REST corepressor 3 Neighboring gene predicted gene 10516 Neighboring gene predicted gene, 39745

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. TNF receptor-associated factor 5 is required for optimal T cell expansion and survival in response to infection. Kraus ZJ, et al. J Immunol, 2008 Dec 1. PMID 19017969, Free PMC Article
    2. TNF Receptor-Associated Factor 5 Limits IL-27 Receptor Signaling in CD4(+) T Lymphocytes. Kawahara E, et al. J Immunol, 2022 Feb 1. PMID 34996840
    3. Genetic Deficiency of TRAF5 Promotes Adipose Tissue Inflammation and Aggravates Diet-Induced Obesity in Mice. Gissler MC, et al. Arterioscler Thromb Vasc Biol, 2021 Oct. PMID 34348490
    4. TRAF5 Deficiency Ameliorates the Severity of Dextran Sulfate Sodium Colitis by Decreasing TRAF2 Expression in Nonhematopoietic Cells. Phung HT, et al. Immunohorizons, 2020 Mar 10. PMID 32156688
    5. Tumor necrosis factor receptor (TNFR)-associated factor 5 is a critical intermediate of costimulatory signaling pathways triggered by glucocorticoid-induced TNFR in T cells. Esparza EM, et al. J Biol Chem, 2006 Mar 31. PMID 16452475

    See all (66) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Tumor necrosis factor receptor-associated factor 5 protects against intimal hyperplasia by regulation of macrophage polarization via directly targeting PPARgamma.
      Title: Tumor necrosis factor receptor-associated factor 5 protects against intimal hyperplasia by regulation of macrophage polarization via directly targeting PPARγ.
    2. TRAF5 regulates intestinal mucosal Th1/Th17 cell immune responses via Runx1 in colitis mice.
      Title: TRAF5 regulates intestinal mucosal Th1/Th17 cell immune responses via Runx1 in colitis mice.
    3. TNF Receptor-Associated Factor 5 Limits IL-27 Receptor Signaling in CD4(+) T Lymphocytes.
      Title: TNF Receptor-Associated Factor 5 Limits IL-27 Receptor Signaling in CD4(+) T Lymphocytes.
    4. Genetic Deficiency of TRAF5 Promotes Adipose Tissue Inflammation and Aggravates Diet-Induced Obesity in Mice.
      Title: Genetic Deficiency of TRAF5 Promotes Adipose Tissue Inflammation and Aggravates Diet-Induced Obesity in Mice.
    5. TRAF5 Deficiency Ameliorates the Severity of Dextran Sulfate Sodium Colitis by Decreasing TRAF2 Expression in Nonhematopoietic Cells.
      Title: TRAF5 Deficiency Ameliorates the Severity of Dextran Sulfate Sodium Colitis by Decreasing TRAF2 Expression in Nonhematopoietic Cells.
    6. TRAF5 deficiency mitigates neointima formation in mice, likely through a TRAF5-dependent decrease in vascular smooth muscle cell proliferation.
      Title: Tumor Necrosis Factor Receptor-Associated Factor 5 Promotes Arterial Neointima Formation through Smooth Muscle Cell Proliferation.
    7. The results demonstrate that gp130-associated TRAF2 and TRAF5 inhibit the interaction between two JAK proteins in the IL-6R complex that is essential for initiating the JAK-STAT signaling pathway.
      Title: TRAF2 and TRAF5 associated with the signal transducing receptor gp130 limit IL-6-driven transphosphorylation of JAK1 through the inhibition of proximal JAK-JAK interaction.
    8. TRAF5 is crucially involved in OSM-mediated lung inflammation probably by inducing lung stromal/fibroblast cell activation.
      Title: TNF receptor associated factor 5 controls oncostatin M-mediated lung inflammation.
    9. our data indicate that Berberine exerts protective effects against chronic renal failurepartly through the TRAF5-mediated activation of the NF-kappaB signaling pathway in mouse podocytes
      Title: Berberine prevents the apoptosis of mouse podocytes induced by TRAF5 overexpression by suppressing NF-κB activation.
    10. this study shows that TRAF2 and TRAF5 work as important regulators of the IL-6R signaling needed for Th17 development
      Title: TNFR-Associated Factors 2 and 5 Differentially Regulate the Instructive IL-6 Receptor Signaling Required for Th17 Development.
    Submit: New GeneRIF Correction See all GeneRIFs (26)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (1)  1 citation

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables identical protein binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables signaling adaptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables thioesterase binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables thioesterase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables tumor necrosis factor receptor binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ubiquitin protein ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ubiquitin protein ligase binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ubiquitin protein ligase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in CD40 signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cell surface receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in interleukin-17-mediated signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in interleukin-17-mediated signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mRNA stabilization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of DNA-binding transcription factor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of NF-kappaB transcription factor activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of NF-kappaB transcription factor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of canonical NF-kappaB signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within positive regulation of cell population proliferation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of canonical NF-kappaB signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within signal transduction IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in signal transduction involved in regulation of gene expression IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in signal transduction involved in regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of CD40 receptor complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in centrosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in centrosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasmic side of plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    part_of plasma membrane signaling receptor complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    TNF receptor-associated factor 5

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_011633.2 → NP_035763.2  TNF receptor-associated factor 5

      See identical proteins and their annotated locations for NP_035763.2

      Status: VALIDATED

      Source sequence(s)
      AK144694, BE691772, BY290436
      UniProtKB/Swiss-Prot
      P70191, Q61480
      UniProtKB/TrEMBL
      Q3UMS9
      Related
      ENSMUSP00000141931.3, ENSMUST00000195815.3
      Conserved Domains (5) summary
      COG1196
      Location:237 → 419
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd03780
      Location:404 → 551
      MATH_TRAF5; Tumor Necrosis Factor Receptor (TNFR)-Associated Factor (TRAF) family, TRAF5 subfamily, TRAF domain, C-terminal MATH subdomain; TRAF molecules serve as adapter proteins that link TNFRs and downstream kinase cascades resulting in the activation of ...
      pfam02176
      Location:128 → 183
      zf-TRAF; TRAF-type zinc finger
      cd16642
      Location:43 → 85
      mRING-HC-C3HC3D_TRAF5; Modified RING finger, HC subclass (C3HC3D-type), found in tumor necrosis factor (TNF) receptor-associated factor 5 (TRAF5) and similar proteins
      cl40617
      Location:185 → 241
      zf-TRAF; TRAF-type zinc finger

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      191729164..191776899 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036163631.1 → XP_036019524.1  TNF receptor-associated factor 5 isoform X1

      UniProtKB/Swiss-Prot
      P70191, Q61480
      UniProtKB/TrEMBL
      Q3UMS9
      Conserved Domains (5) summary
      COG1196
      Location:237 → 419
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd03780
      Location:404 → 551
      MATH_TRAF5; Tumor Necrosis Factor Receptor (TNFR)-Associated Factor (TRAF) family, TRAF5 subfamily, TRAF domain, C-terminal MATH subdomain; TRAF molecules serve as adapter proteins that link TNFRs and downstream kinase cascades resulting in the activation of ...
      pfam02176
      Location:128 → 183
      zf-TRAF; TRAF-type zinc finger
      cd16642
      Location:43 → 85
      mRING-HC-C3HC3D_TRAF5; Modified RING finger, HC subclass (C3HC3D-type), found in tumor necrosis factor (TNF) receptor-associated factor 5 (TRAF5) and similar proteins
      cl40617
      Location:185 → 241
      zf-TRAF; TRAF-type zinc finger

    2. XM_036163634.1 → XP_036019527.1  TNF receptor-associated factor 5 isoform X1

      UniProtKB/Swiss-Prot
      P70191, Q61480
      UniProtKB/TrEMBL
      Q3UMS9
      Conserved Domains (5) summary
      COG1196
      Location:237 → 419
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd03780
      Location:404 → 551
      MATH_TRAF5; Tumor Necrosis Factor Receptor (TNFR)-Associated Factor (TRAF) family, TRAF5 subfamily, TRAF domain, C-terminal MATH subdomain; TRAF molecules serve as adapter proteins that link TNFRs and downstream kinase cascades resulting in the activation of ...
      pfam02176
      Location:128 → 183
      zf-TRAF; TRAF-type zinc finger
      cd16642
      Location:43 → 85
      mRING-HC-C3HC3D_TRAF5; Modified RING finger, HC subclass (C3HC3D-type), found in tumor necrosis factor (TNF) receptor-associated factor 5 (TRAF5) and similar proteins
      cl40617
      Location:185 → 241
      zf-TRAF; TRAF-type zinc finger
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P70191.1 GenPept UniProtKB/Swiss-Prot:P70191

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials