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    ARID3A AT-rich interaction domain 3A [ Homo sapiens (human) ]

    Gene ID: 1820, updated on 10-Dec-2024

    Summary

    Official Symbol
    ARID3Aprovided by HGNC
    Official Full Name
    AT-rich interaction domain 3Aprovided by HGNC
    Primary source
    HGNC:HGNC:3031
    See related
    Ensembl:ENSG00000116017 MIM:603265; AllianceGenome:HGNC:3031
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    DRIL1; DRIL3; BRIGHT; E2FBP1
    Summary
    This gene encodes a member of the ARID (AT-rich interaction domain) family of DNA binding proteins. It was found by homology to the Drosophila dead ringer gene, which is important for normal embryogenesis. Other ARID family members have roles in embryonic patterning, cell lineage gene regulation, cell cycle control, transcriptional regulation, and possibly in chromatin structure modification. [provided by RefSeq, Jul 2008]
    Expression
    Broad expression in placenta (RPKM 13.1), bone marrow (RPKM 2.3) and 16 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See ARID3A in Genome Data Viewer
    Location:
    19p13.3
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (925732..975939)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (888464..938643)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (926035..975939)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene MPRA-validated peak3217 silencer Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:904059-904817 Neighboring gene R3H domain containing 4 Neighboring gene Sharpr-MPRA regulatory region 9324 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9627 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9628 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9629 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9630 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:918907-919847 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:919848-920787 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9633 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9635 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9634 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9636 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:926209-926969 Neighboring gene KISS1 receptor Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:932426-932957 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:932958-933488 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:934552-935082 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9640 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9641 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:947299-947798 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9642 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13576 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:952365-953066 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:953067-953768 Neighboring gene ReSE screen-validated silencer GRCh37_chr19:953750-953958 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:955173-955874 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:956577-957278 Neighboring gene ReSE screen-validated silencer GRCh37_chr19:957654-957846 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:962809-963327 Neighboring gene ReSE screen-validated silencer GRCh37_chr19:965021-965198 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:980065-980655 Neighboring gene HNF4 motif-containing MPRA enhancer 174 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9644 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:983939-984880 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:990841-991786 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9647 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:993929-994462 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:994463-994995 Neighboring gene WD repeat domain 18 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:996475-997094 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9648 Neighboring gene ReSE screen-validated silencer GRCh37_chr19:1009528-1009718 Neighboring gene glutamate ionotropic receptor NMDA type subunit 3B Neighboring gene transmembrane protein 259

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables chromatin binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables identical protein binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables transcription coregulator activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in positive regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
     
    located_in membrane raft IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    AT-rich interactive domain-containing protein 3A
    Names
    ARID domain-containing 3A
    ARID domain-containing protein 3A
    AT rich interactive domain 3A (BRIGHT- like) protein
    AT rich interactive domain 3A (BRIGHT-like)
    B-cell regulator of IgH transcription
    E2F-binding protein 1
    dead ringer-like 1
    dead ringer-like protein 1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_005224.3NP_005215.1  AT-rich interactive domain-containing protein 3A

      See identical proteins and their annotated locations for NP_005215.1

      Status: REVIEWED

      Source sequence(s)
      AC005379, AC005391, BC060828, U88047
      Consensus CDS
      CCDS12050.1
      UniProtKB/Swiss-Prot
      Q5I858, Q6P9C6, Q8IZA7, Q8N4Z3, Q99856
      Related
      ENSP00000263620.2, ENST00000263620.8
      Conserved Domains (1) summary
      smart00501
      Location:239331
      BRIGHT; BRIGHT, ARID (A/T-rich interaction domain) domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

      Range
      925732..975939
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017026445.2XP_016881934.1  AT-rich interactive domain-containing protein 3A isoform X1

      UniProtKB/Swiss-Prot
      Q5I858, Q6P9C6, Q8IZA7, Q8N4Z3, Q99856
      Conserved Domains (1) summary
      smart00501
      Location:239331
      BRIGHT; BRIGHT, ARID (A/T-rich interaction domain) domain
    2. XM_005259514.5XP_005259571.1  AT-rich interactive domain-containing protein 3A isoform X1

      See identical proteins and their annotated locations for XP_005259571.1

      UniProtKB/Swiss-Prot
      Q5I858, Q6P9C6, Q8IZA7, Q8N4Z3, Q99856
      Conserved Domains (1) summary
      smart00501
      Location:239331
      BRIGHT; BRIGHT, ARID (A/T-rich interaction domain) domain
    3. XM_005259513.6XP_005259570.1  AT-rich interactive domain-containing protein 3A isoform X1

      See identical proteins and their annotated locations for XP_005259570.1

      UniProtKB/Swiss-Prot
      Q5I858, Q6P9C6, Q8IZA7, Q8N4Z3, Q99856
      Conserved Domains (1) summary
      smart00501
      Location:239331
      BRIGHT; BRIGHT, ARID (A/T-rich interaction domain) domain
    4. XM_047438380.1XP_047294336.1  AT-rich interactive domain-containing protein 3A isoform X2

    5. XM_047438381.1XP_047294337.1  AT-rich interactive domain-containing protein 3A isoform X3

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060943.1 Alternate T2T-CHM13v2.0

      Range
      888464..938643
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054320138.1XP_054176113.1  AT-rich interactive domain-containing protein 3A isoform X1

    2. XM_054320139.1XP_054176114.1  AT-rich interactive domain-containing protein 3A isoform X1

    3. XM_054320137.1XP_054176112.1  AT-rich interactive domain-containing protein 3A isoform X1

    4. XM_054320140.1XP_054176115.1  AT-rich interactive domain-containing protein 3A isoform X2

    5. XM_054320142.1XP_054176117.1  AT-rich interactive domain-containing protein 3A isoform X4

    6. XM_054320141.1XP_054176116.1  AT-rich interactive domain-containing protein 3A isoform X3