FGR FGR proto-oncogene, Src family tyrosine kinase [Homo sapiens (human)] - Gene

Summary

Official Symbol: FGRprovided by HGNC
Official Full Name: FGR proto-oncogene, Src family tyrosine kinaseprovided by HGNC
Primary source: HGNC:HGNC:3697
See related: Ensembl:ENSG00000000938 MIM:164940; AllianceGenome:HGNC:3697
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: SRC2; c-fgr; c-src2; p55-Fgr; p58-Fgr; p55c-fgr; p58c-fgr
Summary: This gene is a member of the Src family of protein tyrosine kinases (PTKs). The encoded protein contains N-terminal sites for myristylation and palmitylation, a PTK domain, and SH2 and SH3 domains which are involved in mediating protein-protein interactions with phosphotyrosine-containing and proline-rich motifs, respectively. The protein localizes to plasma membrane ruffles, and functions as a negative regulator of cell migration and adhesion triggered by the beta-2 integrin signal transduction pathway. Infection with Epstein-Barr virus results in the overexpression of this gene. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jul 2008]
Expression: Biased expression in bone marrow (RPKM 57.8), spleen (RPKM 29.9) and 6 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 1p35.3

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	1	NC_000001.11 (27612064..27635185, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	1	NC_060925.1 (27453366..27476486, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	1	NC_000001.10 (27938575..27961696, complement)

Chromosome 1 - NC_000001.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variants in PSMB9 and FGR differentially affect Parkinson's disease risk in GBA and LRRK2 mutation carriers.
Title: Variants in PSMB9 and FGR differentially affect Parkinson's disease risk in GBA and LRRK2 mutation carriers.
A Model for the Signal Initiation Complex Between Arrestin-3 and the Src Family Kinase Fgr.
Title: A Model for the Signal Initiation Complex Between Arrestin-3 and the Src Family Kinase Fgr.
These studies show that Hck and Fgr expression influences inhibitor sensitivity and the pathway to acquired resistance in Flt3-ITD+ AML.
Title: Expression of myeloid Src-family kinases is associated with poor prognosis in AML and influences Flt3-ITD kinase inhibitor acquired resistance.
Fgr is a transforming oncoprotein that functions independently of SH3-SH2 domain regulation
Title: The Src family kinase Fgr is a transforming oncoprotein that functions independently of SH3-SH2 domain regulation.
Fgr protein is overexpressed in acute myelogenous leukemia.
Title: Selective Inhibition of the Myeloid Src-Family Kinase Fgr Potently Suppresses AML Cell Growth in Vitro and in Vivo.
Weighted gene co-expression network analysis of gene modules for the prognosis of esophageal cancer yielded PTAFR and FGR as the most important hub genes for predicting patient survival.
Title: Weighted gene co-expression network analysis of gene modules for the prognosis of esophageal cancer.
the Src tyrosine kinase Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog (FGR) is associated with suberoylanilide hydroxamic acid resistance.
Title: A novel approach to detect resistance mechanisms reveals FGR as a factor mediating HDAC inhibitor SAHA resistance in B-cell lymphoma.
we provide evidence for involvement of HCK and FGR in FCRL4-mediated immunoregulation and for the functional importance of posttranslational modifications of the FCRL4 molecule.
Title: Involvement of the HCK and FGR src-family kinases in FCRL4-mediated immune regulation.
Data indicate that combined treatment using SFK (LYN, HCK, or FGR) and c-KIT inhibitor dasatinib dasatinib and chemotherapy provides a novel approach to increasing p53 activity and enhancing targeting of acute myeloid leukemia (AML) stem cells.
Title: The Src and c-Kit kinase inhibitor dasatinib enhances p53-mediated targeting of human acute myeloid leukemia stem cells by chemotherapeutic agents.
Fgr plays a biologically significant role in ovarian cancer growth and might represent an important target
Title: Functional roles of Src and Fgr in ovarian carcinoma.

Submit: New GeneRIF Correction See all GeneRIFs (13)

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Protein interactions

Protein	Gene	Interaction	Pubs
Envelope surface glycoprotein gp120	env	HIV-1 gp120 downregulates the expression of feline Gardner-Rasheed sarcoma viral oncogene homolog (FGR) in human B cells	PubMed
	env	HIV-1 gp120-treated vaginal epithelial cells show upregulation of feline Gardner-Rasheed sarcoma viral oncogene homolog (FGR) expression as compared to untreated control	PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

SHGC-74489 (e-PCR)
- UniSTS:77865

NoName (e-PCR)
- UniSTS:24107

SHGC-74509 (e-PCR)
- UniSTS:40505

SHGC-74510 (e-PCR)
- UniSTS:77206

GDB:549146 (e-PCR)
- UniSTS:157613

SHGC-6996 (e-PCR)
- UniSTS:63418

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables Fc-gamma receptor I complex binding	IDA Inferred from Direct Assay more info	PubMed
enables histone H2AXY142 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3Y41 kinase activity	IEA Inferred from Electronic Annotation more info
enables immunoglobulin receptor binding	ISS Inferred from Sequence or Structural Similarity more info
enables non-membrane spanning protein tyrosine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables non-membrane spanning protein tyrosine kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables non-membrane spanning protein tyrosine kinase activity	TAS Traceable Author Statement more info
enables phosphotyrosine residue binding	IPI Inferred from Physical Interaction more info	PubMed
enables phosphotyrosine residue binding	ISS Inferred from Sequence or Structural Similarity more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase binding	ISS Inferred from Sequence or Structural Similarity more info
enables protein tyrosine kinase activity	EXP Inferred from Experiment more info	PubMed
enables protein tyrosine kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein tyrosine kinase activity	TAS Traceable Author Statement more info
enables signaling receptor binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in Fc-gamma receptor signaling pathway involved in phagocytosis	TAS Traceable Author Statement more info
involved_in bone mineralization	IEA Inferred from Electronic Annotation more info
involved_in cell differentiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell surface receptor protein tyrosine kinase signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in chromatin remodeling	IEA Inferred from Electronic Annotation more info
involved_in defense response to Gram-positive bacterium	ISS Inferred from Sequence or Structural Similarity more info
involved_in immune response-regulating cell surface receptor signaling pathway	TAS Traceable Author Statement more info	PubMed
involved_in integrin-mediated signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in integrin-mediated signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in integrin-mediated signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in myoblast proliferation	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of inflammatory response to antigenic stimulus	TAS Traceable Author Statement more info
involved_in negative regulation of natural killer cell activation	IEA Inferred from Electronic Annotation more info
involved_in peptidyl-tyrosine phosphorylation	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of cell migration	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of cytokine production	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of mast cell degranulation	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein autophosphorylation	IDA Inferred from Direct Assay more info	PubMed
involved_in protein phosphorylation	TAS Traceable Author Statement more info	PubMed
involved_in regulation of cell shape	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of innate immune response	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of phagocytosis	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of protein kinase activity	ISS Inferred from Sequence or Structural Similarity more info
involved_in response to virus	TAS Traceable Author Statement more info	PubMed
involved_in skeletal system morphogenesis	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
colocalizes_with actin cytoskeleton	ISS Inferred from Sequence or Structural Similarity more info
located_in aggresome	IDA Inferred from Direct Assay more info
colocalizes_with cytoskeleton	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	TAS Traceable Author Statement more info
located_in extracellular exosome	HDA more info	PubMed
located_in extracellular region	TAS Traceable Author Statement more info
located_in mitochondrial inner membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrial intermembrane space	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
colocalizes_with ruffle membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in secretory granule lumen	TAS Traceable Author Statement more info

General protein information

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Preferred Names: tyrosine-protein kinase Fgr

Names: Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog; c-fgr protooncogene; c-src-2 proto-oncogene; feline Gardner-Rasheed sarcoma viral oncogene homolog; p55-c-fgr protein; proto-oncogene c-Fgr; proto-oncogene tyrosine-protein kinase FGR; v-fgr feline Gardner-Rasheed sarcoma viral oncogene homolog

NP_001036194.1

EC 2.7.10.2

NP_001036212.1

EC 2.7.10.2

NP_005239.1

EC 2.7.10.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001042729.2 → NP_001036194.1 tyrosine-protein kinase Fgr

See identical proteins and their annotated locations for NP_001036194.1

Status: REVIEWED

Description

Transcript Variant: This variant (3) initiates at exon A, resulting in a distinct 5' UTR compared to variant 1. Expression of this variant is upregulated by Epstein-Barr virus. Variants 1, 2, and 3 encode the same isoform.

Source sequence(s)

AL031729, BC064382, BQ448283, DA960178, M27454

Consensus CDS

CCDS305.1

UniProtKB/Swiss-Prot

D3DPL7, P09769, Q9UIQ3

UniProtKB/TrEMBL

B7Z6W7

Related

ENSP00000363115.3, ENST00000374003.7

Conserved Domains (3) summary

cd10367
Location:140 → 240

SH2_Src_Fgr; Src homology 2 (SH2) domain found in Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog, Fgr

cl17036
Location:80 → 137

SH3; Src Homology 3 domain superfamily

cl21453
Location:267 → 514

PKc_like; Protein Kinases, catalytic domain
NM_001042747.2 → NP_001036212.1 tyrosine-protein kinase Fgr

See identical proteins and their annotated locations for NP_001036212.1

Status: REVIEWED

Description

Transcript Variant: This variant (2) initiates at exon M3, resulting in a distinct 5' UTR compared to variant 1. Variants 1, 2, and 3 encode the same isoform.

Source sequence(s)

AL031729, BC064382, BI771758, BQ448283, BX495937, DA952771

Consensus CDS

CCDS305.1

UniProtKB/Swiss-Prot

D3DPL7, P09769, Q9UIQ3

UniProtKB/TrEMBL

B7Z6W7

Related

ENSP00000382126.1, ENST00000399173.5

Conserved Domains (3) summary

cd10367
Location:140 → 240

SH2_Src_Fgr; Src homology 2 (SH2) domain found in Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog, Fgr

cl17036
Location:80 → 137

SH3; Src Homology 3 domain superfamily

cl21453
Location:267 → 514

PKc_like; Protein Kinases, catalytic domain
NM_005248.3 → NP_005239.1 tyrosine-protein kinase Fgr

See identical proteins and their annotated locations for NP_005239.1

Status: REVIEWED

Description

Transcript Variant: This variant (1) initiates at exon M4 and represents the longest transcript. It is expressed in myelomonocytic cells. Variants 1, 2, and 3 encode the same isoform.

Source sequence(s)

AL031729, BC064382, BQ448283, DA139476

Consensus CDS

CCDS305.1

UniProtKB/Swiss-Prot

D3DPL7, P09769, Q9UIQ3

UniProtKB/TrEMBL

B7Z6W7

Related

ENSP00000363117.3, ENST00000374005.8

Conserved Domains (3) summary

cd10367
Location:140 → 240

SH2_Src_Fgr; Src homology 2 (SH2) domain found in Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog, Fgr

cl17036
Location:80 → 137

SH3; Src Homology 3 domain superfamily

cl21453
Location:267 → 514

PKc_like; Protein Kinases, catalytic domain