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    nga nicotine adenine dinucleotide glycohydrolase [ Streptococcus dysgalactiae ]

    Gene ID: 83689800, updated on 3-Dec-2024

    Summary

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    Gene symbol
    nga
    Gene description
    nicotine adenine dinucleotide glycohydrolase
    Locus tag
    I6H74_RS02395
    Gene type
    protein coding
    Organism
    Streptococcus dysgalactiae (strain: FDAARGOS_1017, culture-collection: DSM:6176)
    Lineage
    Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae; Streptococcus
    Old locus tag
    I6H74_02390
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    Genomic context

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    NZ_CP066069.1Genomic Context describing neighboring genes Neighboring gene preprotein translocase subunit SecE Neighboring gene transcription termination/antitermination protein NusG Neighboring gene NAD glycohydrolase inhibitor Neighboring gene cholesterol-dependent cytolysin streptolysin O

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NZ_CP066069.1

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Binding of NAD(+)-Glycohydrolase to Streptolysin O Stabilizes Both Toxins and Promotes Virulence of Group A Streptococcus. Velarde JJ, et al. mBio, 2017 Sep 12. PMID 28900022, Free PMC Article
    2. Streptolysin O and its co-toxin NAD-glycohydrolase protect group A Streptococcus from Xenophagic killing. O'Seaghdha M, et al. PLoS Pathog, 2013. PMID 23762025, Free PMC Article
    3. Structural basis of Streptococcus pyogenes immunity to its NAD+ glycohydrolase toxin. Smith CL, et al. Structure, 2011 Feb 9. PMID 21300288, Free PMC Article
    4. Inhibition of Inflammasome-Dependent Interleukin 1β Production by Streptococcal NAD(+)-Glycohydrolase: Evidence for Extracellular Activity. Hancz D, et al. mBio, 2017 Jul 18. PMID 28720729, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General protein information

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    Preferred Names
    nicotine adenine dinucleotide glycohydrolase

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NZ_CP066069.1 Reference assembly

      Range
      455935..457278
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. WP_003058231.1 MULTISPECIES: nicotine adenine dinucleotide glycohydrolase [Streptococcus]

      See identical proteins and their annotated locations for WP_003058231.1

      UniProtKB/TrEMBL
      A0A9X9R4F2, A0A9X9SL28, Q5R2E3
    Nucleotide Protein
    Heading Accession and Version