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    cysM O-phosphoserine sulfhydrylase [ Mycobacterium canettii CIPT 140010059 ]

    Gene ID: 45425314, updated on 11-Dec-2024

    Summary

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    Gene symbol
    cysM
    Gene description
    O-phosphoserine sulfhydrylase
    Locus tag
    MCAN_RS07125
    Gene type
    protein coding
    Organism
    Mycobacterium canettii CIPT 140010059 (strain: CIPT 140010059)
    Lineage
    Bacteria; Bacillati; Actinomycetota; Actinomycetes; Mycobacteriales; Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis complex
    Old locus tag
    MCAN_13541
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    Genomic context

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    Sequence:
    NC_015848.1 (1528093..1529064)

    NC_015848.1Genomic Context describing neighboring genes Neighboring gene CysO-cysteine peptidase Neighboring gene sulfur carrier protein CysO Neighboring gene rhomboid family intramembrane serine protease Neighboring gene glutamate racemase Neighboring gene cyclic nucleotide-degrading phosphodiesterase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_015848.1

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. O-phospho-L-serine and the thiocarboxylated sulfur carrier protein CysO-COSH are substrates for CysM, a cysteine synthase from Mycobacterium tuberculosis. O'Leary SE, et al. Biochemistry, 2008 Nov 4. PMID 18842002, Free PMC Article
    2. Cysteine synthase (CysM) of Mycobacterium tuberculosis is an O-phosphoserine sulfhydrylase: evidence for an alternative cysteine biosynthesis pathway in mycobacteria. Agren D, et al. J Biol Chem, 2008 Nov 14. PMID 18799456
    3. Genomic analysis of smooth tubercle bacilli provides insights into ancestry and pathoadaptation of Mycobacterium tuberculosis. Supply P, et al. Nat Genet, 2013 Feb. PMID 23291586, Free PMC Article
    4. The genome of Mycobacterium africanum West African 2 reveals a lineage-specific locus and genome erosion common to the M. tuberculosis complex. Bentley SD, et al. PLoS Negl Trop Dis, 2012. PMID 22389744, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Homology

    General protein information

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    Preferred Names
    O-phosphoserine sulfhydrylase
    WP_003406912.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_015848.1 Reference assembly

      Range
      1528093..1529064
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. WP_003406912.1 MULTISPECIES: O-phosphoserine sulfhydrylase [Mycobacterium]

      See identical proteins and their annotated locations for WP_003406912.1

      UniProtKB/Swiss-Prot
      A0A1R3XZ12, L0T934, P63873, P63874, P9WP52, P9WP53, Q10624, X2BHT6
      UniProtKB/TrEMBL
      A0A045IS51, A0A0H3L8K8, A0A0H3MA46, A0A679LDG6, A0A7V9W7Y4, A0A829C4A8, A0AAU0QBC3, A0AAW8I239, A5U236, R4MHB1
      Conserved Domains (1) summary
      cl00342
      Location:7 → 306
      Trp-synth-beta_II; Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan ...
    Nucleotide Protein
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