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    ahpC peroxiredoxin AhpC [ Mycobacterium canettii CIPT 140010059 ]

    Gene ID: 45426418, updated on 11-Dec-2024

    Summary

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    Gene symbol
    ahpC
    Gene description
    peroxiredoxin AhpC
    Locus tag
    MCAN_RS12945
    Gene type
    protein coding
    RefSeq status
    PIPELINE
    Organism
    Mycobacterium canettii CIPT 140010059 (strain: CIPT 140010059)
    Lineage
    Bacteria; Bacillati; Actinomycetota; Actinomycetes; Mycobacteriales; Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis complex
    Old locus tag
    MCAN_24661
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    Genomic context

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    Sequence:
    NC_015848.1 (2789456..2790043)

    NC_015848.1Genomic Context describing neighboring genes Neighboring gene glutamate-5-semialdehyde dehydrogenase Neighboring gene pseudo Neighboring gene alkyl hydroperoxide reductase Neighboring gene PPE family protein Neighboring gene PE family protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_015848.1

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Intermolecular interactions in the AhpC/AhpD antioxidant defense system of Mycobacterium tuberculosis. Koshkin A, et al. Arch Biochem Biophys, 2004 Jul 1. PMID 15178486
    2. Characterization of the Mycobacterium tuberculosis H37Rv alkyl hydroperoxidase AhpC points to the importance of ionic interactions in oligomerization and activity. Chauhan R, et al. Biochem J, 2001 Feb 15. PMID 11171096, Free PMC Article
    3. The AhpC and AhpD antioxidant defense system of Mycobacterium tuberculosis. Hillas PJ, et al. J Biol Chem, 2000 Jun 23. PMID 10766746
    4. Compensatory ahpC gene expression in isoniazid-resistant Mycobacterium tuberculosis. Sherman DR, et al. Science, 1996 Jun 14. PMID 8658136
    5. Structure and mechanism of the alkyl hydroperoxidase AhpC, a key element of the Mycobacterium tuberculosis defense system against oxidative stress. Guimarães BG, et al. J Biol Chem, 2005 Jul 8. PMID 15886207

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Homology

    General protein information

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    Preferred Names
    peroxiredoxin AhpC
    WP_003412529.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_015848.1 Reference assembly

      Range
      2789456..2790043
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. WP_003412529.1 MULTISPECIES: peroxiredoxin AhpC [Mycobacteriaceae]

      Status: PIPELINE

      UniProtKB/Swiss-Prot
      L0T9L3, P9WQB6, P9WQB7, Q79FE2, Q7BHK8, Q7D758
      UniProtKB/TrEMBL
      A0A0H3LCJ2, A0A0H3M8M8, A0A1R3Y168, A0A7W0AME3, A0A829C2Z9, A0A9P2M4I4, A0AAU0Q416, A0AAW8I1T4, A0AAX1PU29, A5U5C4, G8FRW1, Q50557, Q50558, Q50572, Q50573, Q50574, Q57348, Q79CV0, R4MIV7, V5NF07
      Conserved Domains (1) summary
      cd03015
      Location:6 → 181
      PRX_Typ2cys; Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides. ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P9WQB7.1

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