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    pimA phosphatidyl-myo-inositol alpha-mannosyltransferase [ Mycobacterium canettii CIPT 140010059 ]

    Gene ID: 45426613, updated on 11-Dec-2024

    Summary

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    Gene symbol
    pimA
    Gene description
    phosphatidyl-myo-inositol alpha-mannosyltransferase
    Locus tag
    MCAN_RS13930
    Gene type
    protein coding
    Organism
    Mycobacterium canettii CIPT 140010059 (strain: CIPT 140010059)
    Lineage
    Bacteria; Bacillati; Actinomycetota; Actinomycetes; Mycobacteriales; Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis complex
    Old locus tag
    MCAN_26531
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    Genomic context

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    Sequence:
    NC_015848.1 (3007560..3008696, complement)

    NC_015848.1Genomic Context describing neighboring genes Neighboring gene PE-PPE domain-containing protein Neighboring gene NUDIX domain-containing protein Neighboring gene phosphatidylinositol mannoside acyltransferase Neighboring gene ATP adenylyltransferase Neighboring gene phosphatidylinositol phosphate synthase Neighboring gene threonine--tRNA ligase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_015848.1

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Definition of the first mannosylation step in phosphatidylinositol mannoside synthesis. PimA is essential for growth of mycobacteria. Korduláková J, et al. J Biol Chem, 2002 Aug 30. PMID 12068013
    2. The phosphatidyl-myo-inositol mannosyltransferase PimA is essential for Mycobacterium tuberculosis growth in vitro and in vivo. Boldrin F, et al. J Bacteriol, 2014 Oct. PMID 25049093, Free PMC Article
    3. New insights into the early steps of phosphatidylinositol mannoside biosynthesis in mycobacteria: PimB' is an essential enzyme of Mycobacterium smegmatis. Guerin ME, et al. J Biol Chem, 2009 Sep 18. PMID 19638342, Free PMC Article
    4. Genomic analysis of smooth tubercle bacilli provides insights into ancestry and pathoadaptation of Mycobacterium tuberculosis. Supply P, et al. Nat Genet, 2013 Feb. PMID 23291586, Free PMC Article
    5. The genome of Mycobacterium africanum West African 2 reveals a lineage-specific locus and genome erosion common to the M. tuberculosis complex. Bentley SD, et al. PLoS Negl Trop Dis, 2012. PMID 22389744, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Homology

    General protein information

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    Preferred Names
    phosphatidyl-myo-inositol alpha-mannosyltransferase
    WP_003413478.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_015848.1 Reference assembly

      Range
      3007560..3008696 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. WP_003413478.1 MULTISPECIES: phosphatidyl-myo-inositol alpha-mannosyltransferase [Mycobacterium]

      See identical proteins and their annotated locations for WP_003413478.1

      UniProtKB/Swiss-Prot
      A0A1R3Y1Q5, L0TD24, O06204, P9WMZ4, P9WMZ5, Q7TY88, Q8VJF2, X2BLU2
      UniProtKB/TrEMBL
      A0A045GUR3, A0A0H3LCC9, A0A0H3MCZ7, A0A679LH20, A0A7W0ALV4, A0A829CCS8, A0A9P2M5D6, A0AAU0Q4G8, A0AAW8I5A8, A0AAX1PTM5, A5U5W1
      Conserved Domains (1) summary
      cd03801
      Location:2 → 365
      GT4_PimA-like; phosphatidyl-myo-inositol mannosyltransferase
    Nucleotide Protein
    Heading Accession and Version

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