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    fes.S FES proto-oncogene, tyrosine kinase S homeolog [ Xenopus laevis (African clawed frog) ]

    Gene ID: 444292, updated on 9-Dec-2024

    Summary

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    Official Symbol
    fes.S
    Official Full Name
    FES proto-oncogene, tyrosine kinase S homeolog
    Primary source
    Xenbase:XB-GENE-6067143
    Locus tag
    XELAEV_18020544mg
    See related
    EnsemblRapid:ENSXLAG00005013612 AllianceGenome:Xenbase:XB-GENE-6067143
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Xenopus laevis
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
    Also known as
    fes; fps; c-fes
    Summary
    Predicted to enable ATP binding activity and non-membrane spanning protein tyrosine kinase activity. Predicted to act upstream of or within several processes, including chemotaxis; peptidyl-tyrosine phosphorylation; and regulation of mast cell degranulation. Predicted to be located in cytoplasm; cytoskeleton; and membrane. Human ortholog(s) of this gene implicated in esophagus squamous cell carcinoma; hepatocellular carcinoma; and lung adenocarcinoma. Orthologous to human FES (FES proto-oncogene, tyrosine kinase). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See fes.S in Genome Data Viewer
    Location:
    chromosome: 3S
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    101 current Xenopus_laevis_v10.1 (GCF_017654675.1) 3S NC_054376.1 (46368153..46420913, complement)
    100 previous assembly Xenopus_laevis_v2 (GCF_001663975.1) 3S NC_030729.1 (45092792..45145501, complement)

    Chromosome 3S - NC_054376.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC121402153 Neighboring gene mannosidase, alpha, class 2A, member 2 S homeolog Neighboring gene furin, paired basic amino acid cleaving enzyme S homeolog Neighboring gene ribosomal protein L37a S homeolog Neighboring gene microfibril associated protein 1 S homeolog

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Genetic and genomic tools for Xenopus research: The NIH Xenopus initiative. Klein SL, et al. Dev Dyn, 2002 Dec. PMID 12454917
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Clone Names

    • MGC80946

    Gene Ontology Provided by Xenbase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AXY142 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3Y41 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables non-membrane spanning protein tyrosine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein tyrosine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    FES proto-oncogene, tyrosine kinase S homeolog; tyrosine-protein kinase Fes/Fps

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Xenopus_laevis_v10.1 Primary Assembly

    Genomic

    1. NC_054376.1 Reference Xenopus_laevis_v10.1 Primary Assembly

      Range
      46368153..46420913 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_041588254.1 → XP_041444188.1  tyrosine-protein kinase Fes/Fps

      UniProtKB/TrEMBL
      A0A8J1MS51, Q6GNQ8
      Related
      ENSXLAP00005040140.1, ENSXLAT00005041063.1
      Conserved Domains (3) summary
      cd07685
      Location:7 → 243
      F-BAR_Fes; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Fes (feline sarcoma) tyrosine kinase
      cd10361
      Location:453 → 537
      SH2_Fps_family; Src homology 2 (SH2) domain found in feline sarcoma, Fujinami poultry sarcoma, and fes-related (Fes/Fps/Fer) proteins
      cd05084
      Location:564 → 815
      PTKc_Fes; Catalytic domain of the Protein Tyrosine Kinase, Fes

    2. XM_041588255.1 → XP_041444189.1  tyrosine-protein kinase Fes/Fps

      UniProtKB/TrEMBL
      A0A8J1MS51, Q6GNQ8
      Conserved Domains (3) summary
      cd07685
      Location:7 → 243
      F-BAR_Fes; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Fes (feline sarcoma) tyrosine kinase
      cd10361
      Location:453 → 537
      SH2_Fps_family; Src homology 2 (SH2) domain found in feline sarcoma, Fujinami poultry sarcoma, and fes-related (Fes/Fps/Fer) proteins
      cd05084
      Location:564 → 815
      PTKc_Fes; Catalytic domain of the Protein Tyrosine Kinase, Fes

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001092396.1: Suppressed sequence

      Description
      NM_001092396.1: This RefSeq was removed because it is a nonsense-mediated mRNA decay (NMD) candidate.
    Nucleotide Protein Strain
    Heading Accession and Version

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