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    OCLN occludin [ Canis lupus familiaris (dog) ]

    Gene ID: 403844, updated on 17-Aug-2024

    Summary

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    Official Symbol
    OCLNprovided by VGNC
    Official Full Name
    occludinprovided by VGNC
    Primary source
    VGNC:VGNC:44094
    See related
    Ensembl:ENSCAFG00845012752
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Canis lupus familiaris (sub-species: familiaris)
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
    Orthologs
    human mouse all
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    Genomic context

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    See OCLN in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    106 current ROS_Cfam_1.0 (GCF_014441545.1) 2 NC_051806.1 (55004936..55058838)
    106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 2 NC_006584.4 (51466637..51511781)
    106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 2 NC_049223.1 (53733721..53779092)
    106 current UMICH_Zoey_3.1 (GCF_005444595.1) 2 NC_049262.1 (52076201..52121488)
    106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 2 NC_049743.1 (52843313..52888432)

    Chromosome 2 - NC_051806.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC119870032 Neighboring gene uncharacterized LOC119870033 Neighboring gene MICOS complex subunit MIC27-like Neighboring gene general transcription factor IIH subunit 2 Neighboring gene uncharacterized LOC119870283 Neighboring gene survival motor neuron

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Possible involvement of phosphorylation of occludin in tight junction formation. Sakakibara A, et al. J Cell Biol, 1997 Jun 16. PMID 9182670, Free PMC Article
    2. Occludin localizes to centrosomes and modifies mitotic entry. Runkle EA, et al. J Biol Chem, 2011 Sep 2. PMID 21757728, Free PMC Article
    3. Occludin 1B, a variant of the tight junction protein occludin. Muresan Z, et al. Mol Biol Cell, 2000 Feb. PMID 10679019, Free PMC Article
    4. Cholesterol efflux stimulates metalloproteinase-mediated cleavage of occludin and release of extracellular membrane particles containing its C-terminal fragments. Casas E, et al. Exp Cell Res, 2010 Feb 1. PMID 19854171, Free PMC Article
    5. Cholesterol depletion alters detergent-specific solubility profiles of selected tight junction proteins and the phosphorylation of occludin. Lynch RD, et al. Exp Cell Res, 2007 Jul 15. PMID 17574235, Free PMC Article

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Angulin-1 seals tricellular contacts independently of tricellulin and claudins.
      Title: Angulin-1 seals tricellular contacts independently of tricellulin and claudins.
    2. In the present study, organspecific expression of the tight junction proteins, claudin, occludin, junction adhesion molecule A and zona occludens 1 was examined in the canine duodenum, lung, liver and kidney.
      Title: Expression of claudins, occludin, junction adhesion molecule A and zona occludens 1 in canine organs.
    3. Occludin and ZO-1 expression remained unchanged between atopic and clinically normal dogs.
      Title: Tight junction proteins in the canine epidermis: a pilot study on their distribution in normal and in high IgE-producing canines.
    4. EhCP112 and EhADH112 co-localize with occludin and claudin-1 at tight junctions.
      Title: The EhCPADH112 complex of Entamoeba histolytica interacts with tight junction proteins occludin and claudin-1 to produce epithelial damage.
    5. occludin has a role in centrosome separation and mitosis
      Title: Occludin localizes to centrosomes and modifies mitotic entry.
    6. The 41- and 48-kDa C-terminal occludin fragments formed during cholesterol depletion result from the action of a GM6001-sensitive metalloproteinase(s) at some point in the path leading to release of the membrane particles.
      Title: Cholesterol efflux stimulates metalloproteinase-mediated cleavage of occludin and release of extracellular membrane particles containing its C-terminal fragments.
    7. Elevated expression of p110 CUX1 causes loss of E-cadherin and Occludin from cell-cell junctions
      Title: p110 CUX1 homeodomain protein stimulates cell migration and invasion in part through a regulatory cascade culminating in the repression of E-cadherin and occludin.
    8. a unique motif in the occludin sequence that is involved in the regulation of ZO-1 binding by reversible phosphorylation of specific Tyr residues.
      Title: Phosphorylation of Tyr-398 and Tyr-402 in occludin prevents its interaction with ZO-1 and destabilizes its assembly at the tight junctions.
    9. Knockdown of occludin caused mislocalization of tricellulin to bTJs, implying that occludin supports tricellular localization of tricellulin by excluding tricellulin from bicellular tight junctions.
      Title: Loss of occludin affects tricellular localization of tricellulin.
    10. Removing Cholesterol from the plasma membrane increased tyrosine and threonine phosphorylation of occludin, and transepithelial electrical resistance (TER).
      Title: Cholesterol depletion alters detergent-specific solubility profiles of selected tight junction proteins and the phosphorylation of occludin.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Process Evidence Code Pubs
    involved_in bicellular tight junction assembly IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in apical plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in bicellular tight junction IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in cytoplasmic vesicle IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    occludin
    NP_001003195.1
    XP_038513646.1
    XP_038513647.1
    XP_038513648.1
    XP_038513649.1
    XP_038513650.1
    XP_038513651.1
    XP_038513652.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001003195.1 → NP_001003195.1  occludin

      See identical proteins and their annotated locations for NP_001003195.1

      Status: PROVISIONAL

      Source sequence(s)
      U49221
      UniProtKB/Swiss-Prot
      Q28269
      UniProtKB/TrEMBL
      A0A8C0M4A4, A0A8I3NDV4
      Conserved Domains (2) summary
      pfam01284
      Location:58 → 262
      MARVEL; Membrane-associating domain
      pfam07303
      Location:422 → 517
      Occludin_ELL; Occludin homology domain

    RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ROS_Cfam_1.0

    Genomic

    1. NC_051806.1 Reference ROS_Cfam_1.0

      Range
      55004936..55058838
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038657721.1 → XP_038513649.1  occludin isoform X1

      UniProtKB/TrEMBL
      A0A8C0L4R1, A0A8C0M4A4, A0A8C0Q9S1, A0A8I3NDN4, A0A8I3NDV4
      Related
      ENSCAFP00845017787.1, ENSCAFT00845022680.1
      Conserved Domains (2) summary
      pfam01284
      Location:57 → 262
      MARVEL; Membrane-associating domain
      pfam07303
      Location:419 → 518
      Occludin_ELL; Occludin homology domain

    2. XM_038657718.1 → XP_038513646.1  occludin isoform X1

      UniProtKB/TrEMBL
      A0A8C0L4R1, A0A8C0M4A4, A0A8C0Q9S1, A0A8I3NDN4, A0A8I3NDV4
      Conserved Domains (2) summary
      pfam01284
      Location:57 → 262
      MARVEL; Membrane-associating domain
      pfam07303
      Location:419 → 518
      Occludin_ELL; Occludin homology domain

    3. XM_038657724.1 → XP_038513652.1  occludin isoform X2

      UniProtKB/TrEMBL
      A0A8C0M4A4, A0A8I3NDV4
      Conserved Domains (2) summary
      pfam01284
      Location:57 → 262
      MARVEL; Membrane-associating domain
      pfam07303
      Location:347 → 446
      Occludin_ELL; Occludin homology domain

    4. XM_038657719.1 → XP_038513647.1  occludin isoform X1

      UniProtKB/TrEMBL
      A0A8C0L4R1, A0A8C0M4A4, A0A8C0Q9S1, A0A8I3NDN4, A0A8I3NDV4
      Conserved Domains (2) summary
      pfam01284
      Location:57 → 262
      MARVEL; Membrane-associating domain
      pfam07303
      Location:419 → 518
      Occludin_ELL; Occludin homology domain

    5. XM_038657720.1 → XP_038513648.1  occludin isoform X1

      UniProtKB/TrEMBL
      A0A8C0L4R1, A0A8C0M4A4, A0A8C0Q9S1, A0A8I3NDN4, A0A8I3NDV4
      Conserved Domains (2) summary
      pfam01284
      Location:57 → 262
      MARVEL; Membrane-associating domain
      pfam07303
      Location:419 → 518
      Occludin_ELL; Occludin homology domain

    6. XM_038657722.1 → XP_038513650.1  occludin isoform X1

      UniProtKB/TrEMBL
      A0A8C0L4R1, A0A8C0M4A4, A0A8C0Q9S1, A0A8I3NDN4, A0A8I3NDV4
      Conserved Domains (2) summary
      pfam01284
      Location:57 → 262
      MARVEL; Membrane-associating domain
      pfam07303
      Location:419 → 518
      Occludin_ELL; Occludin homology domain

    7. XM_038657723.1 → XP_038513651.1  occludin isoform X1

      UniProtKB/TrEMBL
      A0A8C0L4R1, A0A8C0M4A4, A0A8C0Q9S1, A0A8I3NDN4, A0A8I3NDV4
      Related
      ENSCAFP00845017865.1, ENSCAFT00845022789.1
      Conserved Domains (2) summary
      pfam01284
      Location:57 → 262
      MARVEL; Membrane-associating domain
      pfam07303
      Location:419 → 518
      Occludin_ELL; Occludin homology domain

    Alternate UMICH_Zoey_3.1

    Genomic

    1. NC_049262.1 Alternate UMICH_Zoey_3.1

      Range
      52076201..52121488
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate UNSW_CanFamBas_1.0

    Genomic

    1. NC_049743.1 Alternate UNSW_CanFamBas_1.0

      Range
      52843313..52888432
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate UU_Cfam_GSD_1.0

    Genomic

    1. NC_049223.1 Alternate UU_Cfam_GSD_1.0

      Range
      53733721..53779092
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate Dog10K_Boxer_Tasha Primary Assembly

    Genomic

    1. NC_006584.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

      Range
      51466637..51511781
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q28269.1 GenPept UniProtKB/Swiss-Prot:Q28269

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