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    Pyroxd2 pyridine nucleotide-disulphide oxidoreductase domain 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 309381, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Pyroxd2provided by RGD
    Official Full Name
    pyridine nucleotide-disulphide oxidoreductase domain 2provided by RGD
    Primary source
    RGD:1303232
    See related
    EnsemblRapid:ENSRNOG00000015807 AllianceGenome:RGD:1303232
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1303232
    Summary
    Predicted to enable oxidoreductase activity. Predicted to be involved in mitochondrion organization. Predicted to be located in mitochondrial matrix. Orthologous to human PYROXD2 (pyridine nucleotide-disulphide oxidoreductase domain 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Kidney (RPKM 614.1), Adrenal (RPKM 74.4) and 5 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Pyroxd2 in Genome Data Viewer
    Location:
    1q54
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (251472609..251498316, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (241523278..241549083, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (261961164..261987029, complement)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134484050 Neighboring gene small nucleolar RNA SNORA17 Neighboring gene TD and POZ domain containing 1, pseudogene 20 Neighboring gene HPS1, biogenesis of lysosomal organelles complex 3 subunit 1 Neighboring gene heparanase 2 (inactive)

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Quantitative high-confidence human mitochondrial proteome and its dynamics in cellular context. Morgenstern M, et al. Cell Metab, 2021 Dec 7. PMID 34800366, Free PMC Article
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Clone Names

    • MGC94853

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in mitochondrion organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mitochondrion organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mitochondrion organization ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in mitochondrial matrix IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrial matrix ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrial matrix ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    pyridine nucleotide-disulfide oxidoreductase domain-containing protein 2
    Names
    Phytn_dehydro and Pyr_redox domain containing protein RGD1303232

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001004261.1 → NP_001004261.1  pyridine nucleotide-disulfide oxidoreductase domain-containing protein 2

      See identical proteins and their annotated locations for NP_001004261.1

      Status: PROVISIONAL

      Source sequence(s)
      BC079368
      UniProtKB/Swiss-Prot
      Q68FT3
      UniProtKB/TrEMBL
      A0A8L2QB18
      Related
      ENSRNOP00000021257.5, ENSRNOT00000021257.6
      Conserved Domains (3) summary
      COG1233
      Location:33 → 571
      COG1233; Phytoene dehydrogenase-related protein [Secondary metabolites biosynthesis, transport and catabolism]
      pfam13450
      Location:39 → 84
      NAD_binding_8; NAD(P)-binding Rossmann-like domain
      cl21454
      Location:278 → 578
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      251472609..251498316 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_008760424.4 → XP_008758646.1  pyridine nucleotide-disulfide oxidoreductase domain-containing protein 2 isoform X1

      UniProtKB/TrEMBL
      A0A8L2QB18
      Conserved Domains (3) summary
      COG1233
      Location:33 → 559
      COG1233; Phytoene dehydrogenase-related protein [Secondary metabolites biosynthesis, transport and catabolism]
      pfam13450
      Location:39 → 84
      NAD_binding_8; NAD(P)-binding Rossmann-like domain
      cl21454
      Location:278 → 559
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

    2. XM_006231394.5 → XP_006231456.1  pyridine nucleotide-disulfide oxidoreductase domain-containing protein 2 isoform X3

      UniProtKB/TrEMBL
      A0A8L2QB18
      Related
      ENSRNOP00000100434.1, ENSRNOT00000153698.1
      Conserved Domains (3) summary
      COG1233
      Location:33 → 559
      COG1233; Phytoene dehydrogenase-related protein [Secondary metabolites biosynthesis, transport and catabolism]
      pfam13450
      Location:39 → 84
      NAD_binding_8; NAD(P)-binding Rossmann-like domain
      cl21454
      Location:278 → 559
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

    3. XM_039080124.2 → XP_038936052.1  pyridine nucleotide-disulfide oxidoreductase domain-containing protein 2 isoform X2

      Conserved Domains (1) summary
      COG1233
      Location:16 → 525
      COG1233; Phytoene dehydrogenase-related protein [Secondary metabolites biosynthesis, transport and catabolism]

    4. XM_006231396.5 → XP_006231458.1  pyridine nucleotide-disulfide oxidoreductase domain-containing protein 2 isoform X4

      UniProtKB/TrEMBL
      A0A8L2QB18
      Conserved Domains (3) summary
      COG1233
      Location:33 → 537
      COG1233; Phytoene dehydrogenase-related protein [Secondary metabolites biosynthesis, transport and catabolism]
      pfam13450
      Location:39 → 84
      NAD_binding_8; NAD(P)-binding Rossmann-like domain
      cl21454
      Location:278 → 514
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

    RNA

    1. XR_005486952.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q68FT3.1 GenPept UniProtKB/Swiss-Prot:Q68FT3

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