grb7 growth factor receptor bound protein 7 [Xenopus tropicalis (tropical clawed frog)] - Gene

Summary

Official Symbol: grb7provided by Xenbase
Official Full Name: growth factor receptor bound protein 7provided by Xenbase
Primary source: Xenbase:XB-GENE-855910
See related: Ensembl:ENSXETG00000015151 AllianceGenome:Xenbase:XB-GENE-855910
Gene type: protein coding
RefSeq status: MODEL
Organism: Xenopus tropicalis
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana
Summary: Predicted to act upstream of or within signal transduction. Predicted to be located in cytoplasm. Human ortholog(s) of this gene implicated in esophagus adenocarcinoma. Orthologous to human GRB7 (growth factor receptor bound protein 7). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 10

Exon count:: 18

Annotation release	Status	Assembly	Chr	Location
104	current	UCB_Xtro_10.0 (GCF_000004195.4)	10	NC_030686.2 (9715002..9771878, complement)
103	previous assembly	Xenopus_tropicalis_v9.1 (GCF_000004195.3)	10	NC_030686.1 (2820500..2877137, complement)

Chromosome 10 - NC_030686.2 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by Xenbase

Process	Evidence Code	Pubs
NOT involved_in insulin receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
NOT involved_in negative regulation of insulin receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: growth factor receptor-bound protein 7

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Xenopus tropicalis Annotation Release 104 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference UCB_Xtro_10.0 Primary Assembly

Genomic

NC_030686.2 Reference UCB_Xtro_10.0 Primary Assembly

Range

9715002..9771878 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_002940372.5 → XP_002940418.2 growth factor receptor-bound protein 7 isoform X1

UniProtKB/TrEMBL

A0A6I8RBI5

Related

ENSXETP00000103139.1, ENSXETT00000109980.1

Conserved Domains (4) summary

cd10413
Location:508 → 615

SH2_Grb7; Src homology 2 (SH2) domain found in the growth factor receptor bound, subclass 7 (Grb7) proteins

cd01259
Location:309 → 431

PH_APBB1IP; Amyloid beta (A4) Precursor protein-Binding, family B, member 1 Interacting Protein pleckstrin homology (PH) domain

cd16140
Location:184 → 271

RA_GRB7; Ras-associating (RA) domain found in growth factor receptor-bound (Grb) protein 7

pfam08947
Location:448 → 492

BPS; BPS (Between PH and SH2)
XM_031894486.1 → XP_031750346.1 growth factor receptor-bound protein 7 isoform X2

UniProtKB/TrEMBL

F6RU56

Related

ENSXETP00000033179.4, ENSXETT00000033179.4

Conserved Domains (4) summary

cd10413
Location:443 → 550

SH2_Grb7; Src homology 2 (SH2) domain found in the growth factor receptor bound, subclass 7 (Grb7) proteins

cd01259
Location:244 → 366

PH_APBB1IP; Amyloid beta (A4) Precursor protein-Binding, family B, member 1 Interacting Protein pleckstrin homology (PH) domain

cd16140
Location:119 → 206

RA_GRB7; Ras-associating (RA) domain found in growth factor receptor-bound (Grb) protein 7

pfam08947
Location:383 → 427

BPS; BPS (Between PH and SH2)
XM_004918677.4 → XP_004918734.1 growth factor receptor-bound protein 7 isoform X3

UniProtKB/TrEMBL

A0A803JYW8

Related

ENSXETP00000113218.1, ENSXETT00000105700.1

Conserved Domains (4) summary

cd10413
Location:425 → 532

SH2_Grb7; Src homology 2 (SH2) domain found in the growth factor receptor bound, subclass 7 (Grb7) proteins

cd01259
Location:226 → 348

PH_APBB1IP; Amyloid beta (A4) Precursor protein-Binding, family B, member 1 Interacting Protein pleckstrin homology (PH) domain

cd16140
Location:101 → 188

RA_GRB7; Ras-associating (RA) domain found in growth factor receptor-bound (Grb) protein 7

pfam08947
Location:365 → 409

BPS; BPS (Between PH and SH2)