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    Rps27l ribosomal protein S27-like [ Mus musculus (house mouse) ]

    Gene ID: 67941, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Rps27lprovided by MGI
    Official Full Name
    ribosomal protein S27-likeprovided by MGI
    Primary source
    MGI:MGI:1915191
    See related
    Ensembl:ENSMUSG00000036781 AllianceGenome:MGI:1915191
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    1810034D23Rik
    Summary
    Predicted to enable RNA binding activity; cysteine-type endopeptidase activator activity involved in apoptotic process; and translation activator activity. Predicted to be a structural constituent of ribosome. Predicted to be involved in intracellular signal transduction; positive regulation of protein metabolic process; and ribosomal small subunit assembly. Predicted to be located in nucleus. Predicted to be part of cytosolic small ribosomal subunit. Is expressed in several structures, including alimentary system; lung; nose; skeletal musculature; and ventricular layer. Orthologous to human RPS27L (ribosomal protein S27 like). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in placenta adult (RPKM 58.6), liver E14 (RPKM 50.1) and 22 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Rps27l in Genome Data Viewer
    Location:
    9 C; 9 36.23 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (66851906..66856804)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (66944624..66949522)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E10560 Neighboring gene STARR-seq mESC enhancer starr_24481 Neighboring gene STARR-positive B cell enhancer ABC_E8297 Neighboring gene aph1 homolog C, gamma secretase subunit Neighboring gene RAB8B, member RAS oncogene family Neighboring gene predicted gene, 40528 Neighboring gene STARR-positive B cell enhancer ABC_E5081 Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:66767210-66767393 Neighboring gene STARR-positive B cell enhancer ABC_E5082 Neighboring gene STARR-seq mESC enhancer starr_24483 Neighboring gene lactamase, beta Neighboring gene STARR-seq mESC enhancer starr_24484 Neighboring gene predicted gene, 30639

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Inactivation of ribosomal protein S27-like confers radiosensitivity via the Mdm2-p53 and Mdm2-MRN-ATM axes. Zhao Y, et al. Cell Death Dis, 2018 Feb 2. PMID 29396424, Free PMC Article
    2. Subfunctionalized expression drives evolutionary retention of ribosomal protein paralogs Rps27 and Rps27l in vertebrates. Xu AF, et al. Elife, 2023 Jun 12. PMID 37306301, Free PMC Article
    3. Ribosomal protein S27-like is a physiological regulator of p53 that suppresses genomic instability and tumorigenesis. Xiong X, et al. Elife, 2014 Aug 21. PMID 25144937, Free PMC Article
    4. Deletion in the N-terminal half of olfactomedin 1 modifies its interaction with synaptic proteins and causes brain dystrophy and abnormal behavior in mice. Nakaya N, et al. Exp Neurol, 2013 Dec. PMID 24095980, Free PMC Article
    5. Neural progenitor genes. Germinal zone expression and analysis of genetic overlap in stem cell populations. Easterday MC, et al. Dev Biol, 2003 Dec 15. PMID 14651920

    See all (31) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. This study revealed a physiological condition under which Rps27l regulates the Mdm2/p53 and MRN/Atm axes to maintain DNA damage response and to confer radioprotection in vivo.
      Title: Inactivation of ribosomal protein S27-like confers radiosensitivity via the Mdm2-p53 and Mdm2-MRN-ATM axes.
    2. Data suggest that ribosomal protein S27-like (Rps27l) is an essential gene for postnatal development by modulating tumor suppressor protein p53.
      Title: Ribosomal protein S27-like is a physiological regulator of p53 that suppresses genomic instability and tumorigenesis.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2)  1 citation
    • Gene trapped (1) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cysteine-type endopeptidase activator activity involved in apoptotic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables structural constituent of ribosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables structural constituent of ribosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables translation activator activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mitotic G1 DNA damage checkpoint signaling ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of cysteine-type endopeptidase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of translation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in ribosomal small subunit assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in translation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  
    part_of cytosolic small ribosomal subunit IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of ribonucleoprotein complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in ribosome IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    small ribosomal subunit protein eS27-like
    Names
    40S ribosomal protein S27-like protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001311101.2 → NP_001298030.1  small ribosomal subunit protein eS27-like isoform 1

      See identical proteins and their annotated locations for NP_001298030.1

      Status: VALIDATED

      Source sequence(s)
      AC159741, AV040832, BE133731, BY088997
      Consensus CDS
      CCDS81028.1
      UniProtKB/TrEMBL
      D3YYB0
      Related
      ENSMUSP00000120518.2, ENSMUST00000127896.8
      Conserved Domains (1) summary
      cl00897
      Location:6 → 80
      Ribosomal_S27e; Ribosomal protein S27

    2. NM_001361106.1 → NP_001348035.1  small ribosomal subunit protein eS27-like isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC159741
      UniProtKB/TrEMBL
      A0A0G2JDW7
      Related
      ENSMUST00000143044.2
      Conserved Domains (1) summary
      PLN00209
      Location:20 → 96
      PLN00209; ribosomal protein S27; Provisional

    3. NM_026467.5 → NP_080743.1  small ribosomal subunit protein eS27-like isoform 2

      See identical proteins and their annotated locations for NP_080743.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate exon in the 3' coding region that results in a frame-shift compared to variant 1. It encodes isoform 2, which is shorter than and has a distinct C-terminus compared to isoform 1.
      Source sequence(s)
      AC159741, AK007689, AV040832, BY088997
      Consensus CDS
      CCDS40673.1
      UniProtKB/Swiss-Prot
      Q3UB68, Q6ZWY3
      UniProtKB/TrEMBL
      A0A0G2JDW7
      Related
      ENSMUSP00000046016.8, ENSMUST00000040917.14
      Conserved Domains (1) summary
      PLN00209
      Location:6 → 82
      PLN00209; ribosomal protein S27; Provisional

    RNA

    1. NR_154464.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC159741

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      66851906..66856804
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017313541.2 → XP_017169030.1  small ribosomal subunit protein eS27-like isoform X1

      Conserved Domains (1) summary
      cl00897
      Location:6 → 80
      Ribosomal_S27e; Ribosomal protein S27
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6ZWY3.3 GenPept UniProtKB/Swiss-Prot:Q6ZWY3

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