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    Npdc1 neural proliferation, differentiation and control, 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 296562, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Npdc1provided by RGD
    Official Full Name
    neural proliferation, differentiation and control, 1provided by RGD
    Primary source
    RGD:1303156
    See related
    EnsemblRapid:ENSRNOG00000090761 AllianceGenome:RGD:1303156
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable ATP binding activity and hydrolase activity. Predicted to be located in membrane. Orthologous to human NPDC1 (neural proliferation, differentiation and control 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 165.9), Lung (RPKM 152.5) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Npdc1 in Genome Data Viewer
    Location:
    3p13
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (28618601..28624591)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (8220446..8226446)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (2624231..2630672)

    Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene suppressor APC domain containing 2 Neighboring gene ectonucleoside triphosphate diphosphohydrolase 2 Neighboring gene ribosomal protein L28, pseudogene 4 Neighboring gene fucosyltransferase 7

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Subcellular localization of neural-specific NPDC-1 protein. Evrard C, et al. J Neurosci Res, 2005 Mar 15. PMID 15678517
    2. NPDC-1, a novel regulator of neuronal proliferation, is degraded by the ubiquitin/proteasome system through a PEST degradation motif. Spencer ML, et al. J Biol Chem, 2004 Aug 27. PMID 15229225
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. NPDC-1 has a role in regulating neuronal proliferation and is degraded by the ubiquitin/proteasome system through a PEST degradation motif
      Title: NPDC-1, a novel regulator of neuronal proliferation, is degraded by the ubiquitin/proteasome system through a PEST degradation motif.
    2. subcellular fractionation of rat brain showed that crude synaptic membrane and crude synaptic vesicle fractions were enriched in NPDC-1.
      Title: Subcellular localization of neural-specific NPDC-1 protein.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC94179

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    neural proliferation differentiation and control protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001004231.1 → NP_001004231.1  neural proliferation differentiation and control protein 1 precursor

      See identical proteins and their annotated locations for NP_001004231.1

      Status: PROVISIONAL

      Source sequence(s)
      BC079156
      UniProtKB/TrEMBL
      A0A8I6AS12, Q6AY81
      Related
      ENSRNOP00000099857.1, ENSRNOT00000158643.1
      Conserved Domains (1) summary
      pfam06809
      Location:1 → 331
      NPDC1; Neural proliferation differentiation control-1 protein (NPDC1)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086021.1 Reference GRCr8

      Range
      28618601..28624591
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039104710.2 → XP_038960638.1  neural proliferation differentiation and control protein 1 isoform X2

      UniProtKB/TrEMBL
      A0A8I6AS12
      Conserved Domains (1) summary
      pfam06809
      Location:1 → 347
      NPDC1; Neural proliferation differentiation control-1 protein (NPDC1)

    2. XM_039104713.2 → XP_038960641.1  neural proliferation differentiation and control protein 1 isoform X5

      UniProtKB/TrEMBL
      A6JT57
      Conserved Domains (1) summary
      pfam06809
      Location:1 → 281
      NPDC1; Neural proliferation differentiation control-1 protein (NPDC1)

    3. XM_039104711.2 → XP_038960639.1  neural proliferation differentiation and control protein 1 isoform X3

      UniProtKB/TrEMBL
      A0A8I6AS12
      Conserved Domains (1) summary
      pfam06809
      Location:1 → 330
      NPDC1; Neural proliferation differentiation control-1 protein (NPDC1)

    4. XM_017591629.3 → XP_017447118.1  neural proliferation differentiation and control protein 1 isoform X1

      UniProtKB/TrEMBL
      A0A8I6AS12, F7EWX9
      Related
      ENSRNOP00000096205.2, ENSRNOT00000112091.2

    5. XM_006233584.5 → XP_006233646.1  neural proliferation differentiation and control protein 1 isoform X4

      UniProtKB/TrEMBL
      A6JT57
      Conserved Domains (1) summary
      pfam06809
      Location:1 → 282
      NPDC1; Neural proliferation differentiation control-1 protein (NPDC1)
    Nucleotide Protein Strain
    Heading Accession and Version

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