Psme2b protease (prosome, macropain) activator subunit 2B [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Psme2bprovided by MGI
Official Full Name: protease (prosome, macropain) activator subunit 2Bprovided by MGI
Primary source: MGI:MGI:1341073
See related: Ensembl:ENSMUSG00000078153 AllianceGenome:MGI:1341073
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: PA28b2; PA28b-p; Psme2b-ps; Psme2-like
Summary: This gene may encode proteasome activator complex subunit 2 protein (PMID: 10222192). This gene, located on chromosome 11, lacks a structured promoter and is intronless. It has also been described as a pseudogene (PMID: 9914329), however, it has an intact coding region and transcripts can be placed at this location unambiguously. An interferon-inducible gene located on chromosome 14, near the gene that encodes proteasome activator complex subunit 1 protein, is considered the functional gene. [provided by RefSeq, Jul 2013]
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Genomic context

Location:: 11 B1.2; 11 28.93 cM

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (48836172..48837237, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (48945345..48946410, complement)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Psme2b is an expressed retrotransposon. Unlike Psme2, Psme2b is constitutive not cytokine-inducible, as a result of insertion into a transcriptionally active LINE1 element.
Title: A second gene encoding the mouse proteasome activator PA28beta subunit is part of a LINE1 element and is driven by a LINE1 promoter.
Psme2b is intronless and lacks a structured promoter so appears to be a processed Psme2 pseudogene.
Title: Characterization of the mouse proteasome regulator PA28b gene.
MEF from mice deficient for PA28a and PA28b do not have detectable mRNA and protein for these proteins even after gamma interferon stimulation, suggesting only one functional copy of PA28a and PA28b.
Title: Immunoproteasome assembly and antigen presentation in mice lacking both PA28alpha and PA28beta.
Induction of PA28 beta expression allows proper PA28 alpha beta complex formation, thereby enhancing proteasome activity in activated dendritic cells.
Title: Differential expression regulation of the alpha and beta subunits of the PA28 proteasome activator in mature dendritic cells.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH71322 (e-PCR)
- UniSTS:84774

MARC_4677-4678:996679594:1 (e-PCR)
- UniSTS:269415

RH129915 (e-PCR)
- UniSTS:213203

Psme2 (e-PCR), detects polymorphism
- UniSTS:256483

RH124942 (e-PCR)
- UniSTS:161764

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables molecular_function	ND No biological Data available more info

Process	Evidence Code	Pubs
involved_in biological_process	ND No biological Data available more info

Component	Evidence Code	Pubs
is_active_in cellular_component	ND No biological Data available more info

General protein information

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Preferred Names: protease (prosome, macropain) 28 subunit beta B

Names: PA28 beta subunit (PA28b) pseudogene; protease (prosome, macropain) 28 subunit beta B, pseudogene; protease (prosome, macropain) 28 subunit, beta, b; proteasome activator complex like

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001281472.1 → NP_001268401.1 protease (prosome, macropain) 28 subunit beta B

See identical proteins and their annotated locations for NP_001268401.1

Status: REVIEWED

Source sequence(s)

BB844325, BE624310, D87910

Consensus CDS

CCDS78934.1

UniProtKB/Swiss-Prot

O35562, P97372

UniProtKB/TrEMBL

A0A1G5SJA5, Q5SVP3

Related

ENSMUSP00000100564.2, ENSMUST00000104958.2

Conserved Domains (2) summary

pfam02251
Location:12 → 66

PA28_alpha; Proteasome activator pa28 alpha subunit

pfam02252
Location:94 → 235

PA28_beta; Proteasome activator pa28 beta subunit

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000077.7 Reference GRCm39 C57BL/6J

Range

48836172..48837237 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NG_005906.4: Suppressed sequence

Description

NG_005906.4: This RefSeq was permanently suppressed because it is now thought that this gene does encode a protein.
NR_003274.1: Suppressed sequence

Description

NR_003274.1: This RefSeq was permanently suppressed because there is insufficient evidence that this locus is transcribed.