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    lrch3 leucine-rich repeats and calponin homology (CH) domain containing 3 [ Danio rerio (zebrafish) ]

    Gene ID: 100126105, updated on 9-Dec-2024

    Summary

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    Official Symbol
    lrch3provided by ZNC
    Official Full Name
    leucine-rich repeats and calponin homology (CH) domain containing 3provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-071004-44
    See related
    Ensembl:ENSDARG00000100679 AllianceGenome:ZFIN:ZDB-GENE-071004-44
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    zgc:171915
    Summary
    Predicted to be located in membrane. Predicted to be active in cytosol. Orthologous to human LRCH3 (leucine rich repeats and calponin homology domain containing 3). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See lrch3 in Genome Data Viewer
    Location:
    chromosome: 18
    Exon count:
    23
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 18 NC_007129.7 (3579861..3645490)
    105 previous assembly GRCz10 (GCF_000002035.5) 18 NC_007129.6 (3482788..3548049)

    Chromosome 18 - NC_007129.7Genomic Context describing neighboring genes Neighboring gene eukaryotic translation initiation factor 2A Neighboring gene stress-associated endoplasmic reticulum protein 1 Neighboring gene uncharacterized LOC137488246 Neighboring gene protein unc-13 homolog C

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Functional and molecular features of the calmodulin-interacting protein IQCG required for haematopoiesis in zebrafish. Chen LT, et al. Nat Commun, 2014 May 2. PMID 24787902
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article
    4. Gene evolution and gene expression after whole genome duplication in fish: the PhyloFish database. Pasquier J, et al. BMC Genomics, 2016 May 18. PMID 27189481, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    leucine-rich repeat and calponin homology domain-containing protein 3; DISP complex protein LRCH3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007129.7 Reference GRCz11 Primary Assembly

      Range
      3579861..3645490
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005173610.5 → XP_005173667.1  DISP complex protein LRCH3 isoform X2

      UniProtKB/TrEMBL
      A0A286YBW2, A0A8M2BKW3
      Related
      ENSDARP00000144520.1, ENSDART00000178789.2
      Conserved Domains (5) summary
      cd00116
      Location:93 → 230
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00033
      Location:61 → 82
      LRR_RI; leucine-rich repeat [structural motif]
      pfam00307
      Location:647 → 754
      CH; Calponin homology (CH) domain
      pfam12799
      Location:105 → 144
      LRR_4; Leucine Rich repeats (2 copies)
      pfam13855
      Location:151 → 207
      LRR_8; Leucine rich repeat

    2. XM_068214867.1 → XP_068070968.1  DISP complex protein LRCH3 isoform X5

      Related
      ENSDARP00000136638.1, ENSDART00000162754.2

    3. XM_005173609.5 → XP_005173666.1  DISP complex protein LRCH3 isoform X1

      UniProtKB/TrEMBL
      A0A8M2BKV2
      Conserved Domains (5) summary
      smart00033
      Location:669 → 741
      CH; Calponin homology domain
      cd00116
      Location:93 → 230
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00033
      Location:61 → 82
      LRR_RI; leucine-rich repeat [structural motif]
      pfam12799
      Location:105 → 144
      LRR_4; Leucine Rich repeats (2 copies)
      pfam13855
      Location:151 → 207
      LRR_8; Leucine rich repeat

    4. XM_005173611.5 → XP_005173668.1  DISP complex protein LRCH3 isoform X4

      UniProtKB/TrEMBL
      A0A8M2BL84
      Conserved Domains (5) summary
      smart00033
      Location:642 → 714
      CH; Calponin homology domain
      cd00116
      Location:93 → 230
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00033
      Location:61 → 82
      LRR_RI; leucine-rich repeat [structural motif]
      pfam12799
      Location:105 → 144
      LRR_4; Leucine Rich repeats (2 copies)
      pfam13855
      Location:151 → 207
      LRR_8; Leucine rich repeat

    5. XM_003200415.6 → XP_003200463.2  DISP complex protein LRCH3 isoform X6

      UniProtKB/TrEMBL
      A0A8M1RFJ0
      Conserved Domains (5) summary
      smart00033
      Location:618 → 690
      CH; Calponin homology domain
      cd00116
      Location:93 → 230
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00033
      Location:61 → 82
      LRR_RI; leucine-rich repeat [structural motif]
      pfam12799
      Location:105 → 144
      LRR_4; Leucine Rich repeats (2 copies)
      pfam13855
      Location:151 → 207
      LRR_8; Leucine rich repeat

    6. XM_017351984.3 → XP_017207473.1  DISP complex protein LRCH3 isoform X3

      UniProtKB/TrEMBL
      A0A8M6YTK7

    7. XM_009293376.4 → XP_009291651.1  DISP complex protein LRCH3 isoform X7

      UniProtKB/TrEMBL
      A0A8M3ARR7
      Conserved Domains (5) summary
      smart00033
      Location:600 → 672
      CH; Calponin homology domain
      cd00116
      Location:93 → 230
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00033
      Location:61 → 82
      LRR_RI; leucine-rich repeat [structural motif]
      pfam12799
      Location:105 → 144
      LRR_4; Leucine Rich repeats (2 copies)
      pfam13855
      Location:151 → 207
      LRR_8; Leucine rich repeat

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001109834.1: Suppressed sequence

      Description
      NM_001109834.1: This RefSeq was suppressed temporarily based on the calculation that the encoded protein was shorter than proteins from the putative ortholog from human: LRCH3 (GeneID:84859).
    Nucleotide Protein
    Heading Accession and Version

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