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    lamb2 laminin, beta 2 (laminin S) [ Danio rerio (zebrafish) ]

    Gene ID: 337767, updated on 14-Nov-2024

    Summary

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    Official Symbol
    lamb2provided by ZNC
    Official Full Name
    laminin, beta 2 (laminin S)provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-081030-4
    See related
    Ensembl:ENSDARG00000002084 AllianceGenome:ZFIN:ZDB-GENE-081030-4
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    si:dkey-32e6.2
    Summary
    Predicted to enable integrin binding activity. Predicted to be a structural constituent of synapse-associated extracellular matrix. Acts upstream of or within several processes, including basement membrane assembly; glial cell development; and muscle attachment. Predicted to be part of laminin complex. Is expressed in several structures, including adaxial cell; heart; musculature system; nervous system; and solid lens vesicle. Human ortholog(s) of this gene implicated in Pierson syndrome; nephrotic syndrome type 5; and primary open angle glaucoma. Orthologous to human LAMB2 (laminin subunit beta 2). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See lamb2 in Genome Data Viewer
    Location:
    chromosome: 23
    Exon count:
    35
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 23 NC_007134.7 (20179532..20258493, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 23 NC_007134.6 (20253204..20333194, complement)

    Chromosome 23 - NC_007134.7Genomic Context describing neighboring genes Neighboring gene si:dkey-32e6.3 Neighboring gene ubiquitin specific peptidase 19 Neighboring gene laminin, beta 2-like Neighboring gene si:rp71-17i16.6

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Quantification of birefringence readily measures the level of muscle damage in zebrafish. Berger J, et al. Biochem Biophys Res Commun, 2012 Jul 13. PMID 22713473
    2. The zebrafish dystrophic mutant softy maintains muscle fibre viability despite basement membrane rupture and muscle detachment. Jacoby AS, et al. Development, 2009 Oct. PMID 19736328, Free PMC Article
    3. Thrombospondin-4 controls matrix assembly during development and repair of myotendinous junctions. Subramanian A, et al. Elife, 2014 Jun 18. PMID 24941943, Free PMC Article
    4. Canonical Wnt signalling regulates epithelial patterning by modulating levels of laminins in zebrafish appendages. Nagendran M, et al. Development, 2015 Jan 15. PMID 25519245, Free PMC Article
    5. Characterization of the laminin gene family and evolution in zebrafish. Sztal T, et al. Dev Dyn, 2011 Feb. PMID 21246659

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. describe a mutant, softy, which displays severe embryonic muscle degeneration as a result of initial basement membrane failure
      Title: The zebrafish dystrophic mutant softy maintains muscle fibre viability despite basement membrane rupture and muscle detachment.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Process Evidence Code Pubs
    acts_upstream_of_or_within basement membrane assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within glial cell development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within muscle attachment IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within retina development in camera-type eye IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within somite development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    laminin subunit beta-2
    Names
    sof
    softy

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001243045.1 → NP_001229974.1  laminin subunit beta-2 precursor

      Status: PROVISIONAL

      Source sequence(s)
      AL953864
      UniProtKB/TrEMBL
      A0A8M1P2Z5, B7ZDA6
      Related
      ENSDARP00000123269.1, ENSDART00000147326.2
      Conserved Domains (9) summary
      smart00180
      Location:767 → 812
      EGF_Lam; Laminin-type epidermal growth factor-like domai
      cd00055
      Location:860 → 905
      EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
      pfam00053
      Location:815 → 863
      Laminin_EGF; Laminin EGF domain
      pfam00055
      Location:41 → 265
      Laminin_N; Laminin N-terminal (Domain VI)
      pfam04012
      Location:1591 → 1774
      PspA_IM30; PspA/IM30 family
      pfam12795
      Location:1459 → 1682
      MscS_porin; Mechanosensitive ion channel porin domain
      pfam16043
      Location:1460 → 1608
      DUF4795; Domain of unknown function (DUF4795)
      cl09176
      Location:1216 → 1324
      FlgN; FlgN protein
      cl21509
      Location:1559 → 1736
      ApoLp-III_like; Apolipophorin-III and similar insect proteins

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007134.7 Reference GRCz11 Primary Assembly

      Range
      20179532..20258493 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005162045.4 → XP_005162102.1  laminin subunit beta-2 isoform X1

      See identical proteins and their annotated locations for XP_005162102.1

      UniProtKB/TrEMBL
      A0A8M2B8V2
      Conserved Domains (9) summary
      smart00180
      Location:767 → 812
      EGF_Lam; Laminin-type epidermal growth factor-like domai
      cd00055
      Location:860 → 905
      EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
      pfam00053
      Location:815 → 863
      Laminin_EGF; Laminin EGF domain
      pfam00055
      Location:41 → 265
      Laminin_N; Laminin N-terminal (Domain VI)
      pfam04012
      Location:1603 → 1786
      PspA_IM30; PspA/IM30 family
      pfam12795
      Location:1471 → 1694
      MscS_porin; Mechanosensitive ion channel porin domain
      pfam16043
      Location:1472 → 1620
      DUF4795; Domain of unknown function (DUF4795)
      cl09176
      Location:1228 → 1336
      FlgN; FlgN protein
      cl21509
      Location:1571 → 1748
      ApoLp-III_like; Apolipophorin-III and similar insect proteins

    2. XM_005162046.4 → XP_005162103.1  laminin subunit beta-2 isoform X1

      See identical proteins and their annotated locations for XP_005162103.1

      UniProtKB/TrEMBL
      A0A8M2B8V2
      Conserved Domains (9) summary
      smart00180
      Location:767 → 812
      EGF_Lam; Laminin-type epidermal growth factor-like domai
      cd00055
      Location:860 → 905
      EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
      pfam00053
      Location:815 → 863
      Laminin_EGF; Laminin EGF domain
      pfam00055
      Location:41 → 265
      Laminin_N; Laminin N-terminal (Domain VI)
      pfam04012
      Location:1603 → 1786
      PspA_IM30; PspA/IM30 family
      pfam12795
      Location:1471 → 1694
      MscS_porin; Mechanosensitive ion channel porin domain
      pfam16043
      Location:1472 → 1620
      DUF4795; Domain of unknown function (DUF4795)
      cl09176
      Location:1228 → 1336
      FlgN; FlgN protein
      cl21509
      Location:1571 → 1748
      ApoLp-III_like; Apolipophorin-III and similar insect proteins

    3. XM_017353525.3 → XP_017209014.1  laminin subunit beta-2 isoform X1

      UniProtKB/TrEMBL
      A0A8M2B8V2
      Conserved Domains (9) summary
      smart00180
      Location:767 → 812
      EGF_Lam; Laminin-type epidermal growth factor-like domai
      cd00055
      Location:860 → 905
      EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
      pfam00053
      Location:815 → 863
      Laminin_EGF; Laminin EGF domain
      pfam00055
      Location:41 → 265
      Laminin_N; Laminin N-terminal (Domain VI)
      pfam04012
      Location:1603 → 1786
      PspA_IM30; PspA/IM30 family
      pfam12795
      Location:1471 → 1694
      MscS_porin; Mechanosensitive ion channel porin domain
      pfam16043
      Location:1472 → 1620
      DUF4795; Domain of unknown function (DUF4795)
      cl09176
      Location:1228 → 1336
      FlgN; FlgN protein
      cl21509
      Location:1571 → 1748
      ApoLp-III_like; Apolipophorin-III and similar insect proteins
    Nucleotide Protein Strain
    Heading Accession and Version

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