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    pkd2 plasma membrane TRP-like calcium ion channel Pkd2 [ Schizosaccharomyces pombe (fission yeast) ]

    Gene ID: 2541613, updated on 18-Sep-2024

    Summary

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    Official Symbol
    pkd2
    Official Full Name
    plasma membrane TRP-like calcium ion channel Pkd2
    Primary source
    PomBase:SPAC1F7.03
    Locus tag
    SPOM_SPAC1F7.03
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Schizosaccharomyces pombe (strain: 972h-)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
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    Genomic context

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    See pkd2 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    1
    Sequence:
    Chromosome: I; NC_003424.3 (4219751..4222702)

    Chromosome I - NC_003424.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ATP-dependent RNA helicase Has1 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene protein tam6 Neighboring gene Rho family GTPase Rho1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003424.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Pkd2, mutations linking to autosomal dominant polycystic kidney disease, localizes to the endoplasmic reticulum and regulates calcium signaling in fission yeast. Koyano T, et al. Genes Cells, 2023 Nov. PMID 37723847
    2. Membrane stretching activates calcium permeability of a putative channel Pkd2 during fission yeast cytokinesis. Poddar A, et al. Mol Biol Cell, 2022 Dec 1. PMID 36200871, Free PMC Article
    3. Fission yeast TRP channel Pkd2p localizes to the cleavage furrow and regulates cell separation during cytokinesis. Morris Z, et al. Mol Biol Cell, 2019 Jul 15. PMID 31116668, Free PMC Article
    4. A microbial TRP-like polycystic-kidney-disease-related ion channel gene. Palmer CP, et al. Biochem J, 2005 Apr 1. PMID 15537393, Free PMC Article
    5. Polycystic kidney disease channel and synaptotagmin homologues play roles in schizosaccharomyces pombe cell wall synthesis/repair and membrane protein trafficking. Aydar E, et al. J Membr Biol, 2009 Jun. PMID 19543678

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Pkd2, mutations linking to autosomal dominant polycystic kidney disease, localizes to the endoplasmic reticulum and regulates calcium signaling in fission yeast.
      Title: Pkd2, mutations linking to autosomal dominant polycystic kidney disease, localizes to the endoplasmic reticulum and regulates calcium signaling in fission yeast.
    2. Membrane stretching activates calcium permeability of a putative channel Pkd2 during fission yeast cytokinesis.
      Title: Membrane stretching activates calcium permeability of a putative channel Pkd2 during fission yeast cytokinesis.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by PomBase

    Function Evidence Code Pubs
    enables calcium channel activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables stretch-activated, monoatomic cation-selective, calcium channel activity EXP
    Inferred from Experiment
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in calcineurin-mediated signaling IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in calcium ion import across plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in calcium ion import across plasma membrane IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in calcium-mediated signaling IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cellular hyperosmotic response IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in fungal-type cell wall biogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in intracellular water homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of cell wall (1->3)-beta-D-glucan biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in Golgi membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cleavage furrow IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in division septum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in plasma membrane of cell tip EXP
    Inferred from Experiment
    more info
    		 PubMed 
    is_active_in plasma membrane of cell tip IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    plasma membrane TRP-like calcium ion channel Pkd2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003424.3 Reference assembly

      Range
      4219751..4222702
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001019918.3 → NP_594489.1  plasma membrane TRP-like calcium ion channel Pkd2 [Schizosaccharomyces pombe]

      See identical proteins and their annotated locations for NP_594489.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      Q09917
      UniProtKB/TrEMBL
      S6BDH3
      Conserved Domains (2) summary
      pfam06011
      Location:171 → 600
      TRP; Transient receptor potential (TRP) ion channel
      pfam14558
      Location:32 → 165
      TRP_N; ML-like domain
    Nucleotide Protein
    Heading Accession and Version

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