LYZL6 lysozyme like 6 [Homo sapiens (human)] - Gene

Summary

Official Symbol: LYZL6provided by HGNC
Official Full Name: lysozyme like 6provided by HGNC
Primary source: HGNC:HGNC:29614
See related: Ensembl:ENSG00000275722 MIM:612751; AllianceGenome:HGNC:29614
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: LYC1; LYZB; UNQ754; PRO1485; TKAL754; HEL-S-6a
Summary: This gene encodes a member of the C-type lysozyme/alpha-lactalbumin family. C-type lysozymes are bacteriolytic factors that play a role in host defense, whereas alpha-lactalbumins mediate lactose biosynthesis. The encoded protein contains catalytic residues characteristic of C-type lysozymes and may play a role in male reproduction. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Jan 2011]
Expression: Restricted expression toward testis (RPKM 15.7) See more
Orthologs: mouse all
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Genomic context

Location:: 17q12

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	17	NC_000017.11 (35934518..35943713, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	17	NC_060941.1 (36882425..36891620, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	17	NC_000017.10 (34261522..34270717, complement)

Chromosome 17 - NC_000017.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Tissue-specific circular RNA induction during human fetal development
Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
BioProject: PRJNA270632
Publication: PMID 26076956
Analysis date: Mon Apr 2 22:54:59 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

LYZL6, an acidic, bacteriolytic and human sperm-related protein, is likely important for fertilization but not for the innate immunity of the male reproductive tract.
Title: LYZL6, an acidic, bacteriolytic, human sperm-related protein, plays a role in fertilization.

Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables lysozyme activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in defense response to bacterium	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in fertilization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in fusion of sperm to egg plasma membrane involved in single fertilization	IBA Inferred from Biological aspect of Ancestor more info
involved_in fusion of sperm to egg plasma membrane involved in single fertilization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in killing of cells of another organism	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in acrosomal vesicle	IBA Inferred from Biological aspect of Ancestor more info
located_in cell surface	IEA Inferred from Electronic Annotation more info
located_in extracellular region	IEA Inferred from Electronic Annotation more info
is_active_in sperm flagellum	IBA Inferred from Biological aspect of Ancestor more info
located_in sperm midpiece	ISS Inferred from Sequence or Structural Similarity more info
located_in sperm plasma membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: lysozyme-like protein 6

Names: epididymis secretory sperm binding protein Li 6a; lysozyme B; lysozyme homolog

NP_001186880.1

EC 3.2.1.17

NP_065159.1

EC 3.2.1.17

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001199951.3 → NP_001186880.1 lysozyme-like protein 6 precursor

See identical proteins and their annotated locations for NP_001186880.1

Status: REVIEWED

Description

Transcript Variant: This variant (1) differs in the 5' UTR, compared to variant 2. Both variants 1 and 2 encode the same protein.

Source sequence(s)

AC244100, AY742214, BC054481, BE550275, DB462957, HY024713

Consensus CDS

CCDS11302.1

UniProtKB/Swiss-Prot

O75951, Q6UW30

UniProtKB/TrEMBL

A0A080YUZ6

Related

ENSP00000482955.1, ENST00000618542.4

Conserved Domains (1) summary

cd00119
Location:22 → 142

LYZ1; C-type lysozyme (1, 4-beta-N-acetylmuramidase, LYZ) and alpha-lactalbumin (lactose synthase B protein, LA). They have a close evolutionary relationship and similar tertiary structure, however, functionally they are quite different. Lysozymes have ...
NM_020426.4 → NP_065159.1 lysozyme-like protein 6 precursor

See identical proteins and their annotated locations for NP_065159.1

Status: REVIEWED

Description

Transcript Variant: This variant (2) represents the longer transcript. Both variants 1 and 2 encode the same protein.

Source sequence(s)

AC244100, AY742214, BC054481, BE550275, DB462957, HY024713

Consensus CDS

CCDS11302.1

UniProtKB/Swiss-Prot

O75951, Q6UW30

UniProtKB/TrEMBL

A0A080YUZ6

Related

ENSP00000483897.1, ENST00000615905.5

Conserved Domains (1) summary

cd00119
Location:22 → 142

LYZ1; C-type lysozyme (1, 4-beta-N-acetylmuramidase, LYZ) and alpha-lactalbumin (lactose synthase B protein, LA). They have a close evolutionary relationship and similar tertiary structure, however, functionally they are quite different. Lysozymes have ...