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    Psat1 phosphoserine aminotransferase 1 [ Mus musculus (house mouse) ]

    Gene ID: 107272, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Psat1provided by MGI
    Official Full Name
    phosphoserine aminotransferase 1provided by MGI
    Primary source
    MGI:MGI:2183441
    See related
    Ensembl:ENSMUSG00000024640 AllianceGenome:MGI:2183441
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    PSA; EPIP; Psat; D8Ertd814e
    Summary
    Predicted to enable O-phospho-L-serine:2-oxoglutarate aminotransferase activity; identical protein binding activity; and pyridoxal phosphate binding activity. Predicted to be involved in L-serine biosynthetic process. Predicted to be located in cytosol. Predicted to be active in cytoplasm. Is expressed in several structures, including alimentary system; genitourinary system; integumental system; nervous system; and sensory organ. Human ortholog(s) of this gene implicated in Neu-Laxova syndrome 2 and PSAT deficiency. Orthologous to human PSAT1 (phosphoserine aminotransferase 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in liver E18 (RPKM 91.8), placenta adult (RPKM 82.6) and 16 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Psat1 in Genome Data Viewer
    Location:
    19 A; 19 10.86 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (15882487..15902423, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (15905123..15925059, complement)

    Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 54054 Neighboring gene predicted gene, 46665 Neighboring gene predicted gene, 31733 Neighboring gene predicted gene, 24319 Neighboring gene STARR-seq mESC enhancer starr_45641 Neighboring gene STARR-seq mESC enhancer starr_45643 Neighboring gene STARR-seq mESC enhancer starr_45644 Neighboring gene STARR-seq mESC enhancer starr_45645 Neighboring gene STARR-positive B cell enhancer ABC_E11025 Neighboring gene CapStarr-seq enhancer MGSCv37_chr19:15999466-15999649 Neighboring gene RIKEN cDNA C130060C02 gene Neighboring gene STARR-positive B cell enhancer ABC_E4269 Neighboring gene centrosomal protein 78

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Psat1-generated α-ketoglutarate and glutamine promote muscle stem cell activation and regeneration. Ciuffoli V, et al. Genes Dev, 2024 Mar 22. PMID 38453480, Free PMC Article
    2. Psat1-Dependent Fluctuations in α-Ketoglutarate Affect the Timing of ESC Differentiation. Hwang IY, et al. Cell Metab, 2016 Sep 13. PMID 27476977
    3. Hepatic Phosphoserine Aminotransferase 1 Regulates Insulin Sensitivity in Mice via Tribbles Homolog 3. Yu J, et al. Diabetes, 2015 May. PMID 25503742
    4. PERK is a critical metabolic hub for immunosuppressive function in macrophages. Raines LN, et al. Nat Immunol, 2022 Mar. PMID 35228694, Free PMC Article
    5. Identifying strategies to target the metabolic flexibility of tumours. Méndez-Lucas A, et al. Nat Metab, 2020 Apr. PMID 32694609, Free PMC Article

    See all (46) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Psat1-generated alpha-ketoglutarate and glutamine promote muscle stem cell activation and regeneration.
      Title: Psat1-generated α-ketoglutarate and glutamine promote muscle stem cell activation and regeneration.
    2. Psat1 is regulated in maintaining intracellular alpha-ketoglutarate levels and determining the fate of mouse Embryonic stem cells.
      Title: Psat1-Dependent Fluctuations in α-Ketoglutarate Affect the Timing of ESC Differentiation.
    3. This study showed that hepatic PSAT1 expression and liver serine levels are reduced in 2 mouse strains, and that PSAT1 inhibited the expression of hepatic TRB3 in vitro and in vivo.
      Title: Hepatic Phosphoserine Aminotransferase 1 Regulates Insulin Sensitivity in Mice via Tribbles Homolog 3.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (5) 
    • Targeted (3)  1 citation

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables O-phospho-L-serine:2-oxoglutarate aminotransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables O-phospho-L-serine:2-oxoglutarate aminotransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables O-phospho-L-serine:2-oxoglutarate aminotransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables identical protein binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables pyridoxal phosphate binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in L-serine biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in L-serine biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in L-serine biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    phosphoserine aminotransferase
    Names
    endometrial progesterone-induced protein
    phosphohydroxythreonine aminotransferase
    NP_001192268.1
    NP_803155.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001205339.1 → NP_001192268.1  phosphoserine aminotransferase isoform 2

      See identical proteins and their annotated locations for NP_001192268.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (2) has a distinct N-terminus and is shorter than isoform 1.
      Source sequence(s)
      AC136453, AK152313
      Consensus CDS
      CCDS57139.1
      UniProtKB/TrEMBL
      Q3U6K9, Q3ULZ3, Q8BTJ1
      Related
      ENSMUSP00000125340.2, ENSMUST00000162053.8
      Conserved Domains (2) summary
      cd00611
      Location:18 → 363
      PSAT_like; Phosphoserine aminotransferase (PSAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major group in this CD corresponds to phosphoserine aminotransferase (PSAT). PSAT is active as ...
      COG1932
      Location:18 → 365
      SerC; Phosphoserine aminotransferase [Coenzyme transport and metabolism, Amino acid transport and metabolism]

    2. NM_177420.2 → NP_803155.1  phosphoserine aminotransferase isoform 1

      See identical proteins and their annotated locations for NP_803155.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the shorter transcript and encodes the longer isoform (1).
      Source sequence(s)
      AK032487, AK167044, AV166058
      Consensus CDS
      CCDS29681.1
      UniProtKB/Swiss-Prot
      Q99K85
      UniProtKB/TrEMBL
      Q3ULZ3, Q543K5, Q8BTJ1
      Related
      ENSMUSP00000025542.4, ENSMUST00000025542.10
      Conserved Domains (2) summary
      cd00611
      Location:8 → 366
      PSAT_like; Phosphoserine aminotransferase (PSAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major group in this CD corresponds to phosphoserine aminotransferase (PSAT). PSAT is active as ...
      COG1932
      Location:6 → 368
      SerC; Phosphoserine aminotransferase [Coenzyme transport and metabolism, Amino acid transport and metabolism]

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000085.7 Reference GRCm39 C57BL/6J

      Range
      15882487..15902423 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    RNA

    1. XR_004940109.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q99K85.1 GenPept UniProtKB/Swiss-Prot:Q99K85

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