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    EGFR epidermal growth factor receptor [ Macaca fascicularis (crab-eating macaque) ]

    Gene ID: 102138724, updated on 3-Dec-2024

    Summary

    Gene symbol
    EGFR
    Gene description
    epidermal growth factor receptor
    See related
    Ensembl:ENSMFAG00000034444
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Macaca fascicularis
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See EGFR in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    31
    Annotation release Status Assembly Chr Location
    RS_2024_05 current T2T-MFA8v1.0 (GCF_037993035.1) 3 NC_088377.1 (75194364..75389010, complement)
    102 previous assembly MFA1912RKSv2 (GCF_012559485.2) 3 NC_052257.1 (124951418..125146140)

    Chromosome 3 - NC_088377.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC135970140 Neighboring gene calmodulin-like Neighboring gene uncharacterized LOC135969959 Neighboring gene rho GTPase-activating protein 5-like

    Genomic regions, transcripts, and products

    General gene information

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    PubMed 
    enables epidermal growth factor binding IEA
    Inferred from Electronic Annotation
    more info
    PubMed 
    enables epidermal growth factor receptor activity IEA
    Inferred from Electronic Annotation
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in basal plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    PubMed 
    part_of receptor complex IEA
    Inferred from Electronic Annotation
    more info
    PubMed 

    General protein information

    Preferred Names
    epidermal growth factor receptor

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs of Annotated Genomes: GCF_037993035.1-RS_2024_05

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference T2T-MFA8v1.0

    Genomic

    1. NC_088377.1 Reference T2T-MFA8v1.0

      Range
      75194364..75389010 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005549559.4XP_005549616.1  epidermal growth factor receptor isoform X1

      See identical proteins and their annotated locations for XP_005549616.1

      UniProtKB/TrEMBL
      A0A2K5WK39, G7P1R4
      Related
      ENSMFAP00000037527.1
      Conserved Domains (5) summary
      cd12093
      Location:634677
      TM_ErbB1; Transmembrane domain of Epidermal Growth Factor Receptor or ErbB1, a Protein Tyrosine Kinase
      cd05108
      Location:7041016
      PTKc_EGFR; Catalytic domain of the Protein Tyrosine Kinase, Epidermal Growth Factor Receptor
      pfam00757
      Location:185335
      Furin-like; Furin-like cysteine rich region
      pfam14843
      Location:505637
      GF_recep_IV; Growth factor receptor domain IV
      pfam01030
      Location:57166
      Recep_L_domain; Receptor L domain
    2. XM_045389159.2XP_045245094.1  epidermal growth factor receptor isoform X2

      UniProtKB/TrEMBL
      G7P1R4
      Conserved Domains (5) summary
      cd12093
      Location:581624
      TM_ErbB1; Transmembrane domain of Epidermal Growth Factor Receptor or ErbB1, a Protein Tyrosine Kinase
      cd05108
      Location:651963
      PTKc_EGFR; Catalytic domain of the Protein Tyrosine Kinase, Epidermal Growth Factor Receptor
      pfam00757
      Location:132282
      Furin-like; Furin-like cysteine rich region
      pfam01030
      Location:4115
      Recep_L_domain; Receptor L domain
      pfam14843
      Location:452584
      GF_recep_IV; Growth factor receptor domain IV
    3. XM_005549560.4XP_005549617.1  epidermal growth factor receptor isoform X2

      UniProtKB/TrEMBL
      G7P1R4
      Related
      ENSMFAP00000037571.1
      Conserved Domains (5) summary
      cd12093
      Location:581624
      TM_ErbB1; Transmembrane domain of Epidermal Growth Factor Receptor or ErbB1, a Protein Tyrosine Kinase
      cd05108
      Location:651963
      PTKc_EGFR; Catalytic domain of the Protein Tyrosine Kinase, Epidermal Growth Factor Receptor
      pfam00757
      Location:132282
      Furin-like; Furin-like cysteine rich region
      pfam01030
      Location:4115
      Recep_L_domain; Receptor L domain
      pfam14843
      Location:452584
      GF_recep_IV; Growth factor receptor domain IV
    4. XM_005549561.4XP_005549618.1  epidermal growth factor receptor isoform X3

      See identical proteins and their annotated locations for XP_005549618.1

      UniProtKB/TrEMBL
      A0A2K5WKC1, A0A2K5WKD8
      Related
      ENSMFAP00000037603.1
      Conserved Domains (3) summary
      pfam00757
      Location:185335
      Furin-like; Furin-like cysteine rich region
      pfam01030
      Location:57168
      Recep_L_domain; Receptor L domain
      pfam14843
      Location:505627
      GF_recep_IV; Growth factor receptor domain IV