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    Calr4 calreticulin 4 [ Mus musculus (house mouse) ]

    Gene ID: 108802, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Calr4provided by MGI
    Official Full Name
    calreticulin 4provided by MGI
    Primary source
    MGI:MGI:2140435
    See related
    Ensembl:ENSMUSG00000028558 AllianceGenome:MGI:2140435
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    4933403L16Rik
    Summary
    Predicted to enable calcium ion binding activity. Predicted to be involved in ERAD pathway and protein folding. Predicted to be active in endoplasmic reticulum membrane. Orthologous to human CALR4P (calreticulin 4, pseudogene). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Low expression observed in reference dataset See more
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    Genomic context

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    See Calr4 in Genome Data Viewer
    Location:
    4 C7; 4 51.1 cM
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (109075610..109112176)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (109218413..109254979)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene oxysterol binding protein-like 9 Neighboring gene STARR-positive B cell enhancer ABC_E6198 Neighboring gene STARR-seq mESC enhancer starr_11065 Neighboring gene predicted gene, 52703 Neighboring gene STARR-positive B cell enhancer ABC_E11807 Neighboring gene predicted gene, 46867 Neighboring gene predicted gene, 40225 Neighboring gene STARR-positive B cell enhancer ABC_E2703 Neighboring gene epidermal growth factor receptor pathway substrate 15 Neighboring gene predicted gene, 52753 Neighboring gene predicted gene, 52702

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Calreticulin chaperones regulate functional expression of vomeronasal type 2 pheromone receptors. Dey S, et al. Proc Natl Acad Sci U S A, 2011 Oct 4. PMID 21933956, Free PMC Article
    2. Deletion of the Wilms' Tumor Suppressor Gene in the Cardiac Troponin-T Lineage Reveals Novel Functions of WT1 in Heart Development. Díaz Del Moral S, et al. Front Cell Dev Biol, 2021. PMID 34368133, Free PMC Article
    3. Inceptor counteracts insulin signalling in β-cells to control glycaemia. Ansarullah, et al. Nature, 2021 Feb. PMID 33505018
    4. Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Ko MS, et al. Development, 2000 Apr. PMID 10725249
    5. Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray. Tanaka TS, et al. Proc Natl Acad Sci U S A, 2000 Aug 1. PMID 10922068, Free PMC Article

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (1) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables calcium ion binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in ERAD pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein folding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    calreticulin 4

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001033226.4 → NP_001028398.1  calreticulin 4 isoform b precursor

      See identical proteins and their annotated locations for NP_001028398.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) has alternate 5' exon structure and it thus differs in the 5' UTR and 5' coding region, compared to variant 1. The encoded isoform (b) has a distinct and shorter N-terminus, compared to isoform a.
      Source sequence(s)
      AK139540, AK163350, BG083829
      Consensus CDS
      CCDS18461.1
      UniProtKB/TrEMBL
      Q3TQS0
      Related
      ENSMUSP00000030285.8, ENSMUST00000030285.8
      Conserved Domains (1) summary
      pfam00262
      Location:13 → 318
      Calreticulin; Calreticulin family

    2. NM_001285895.1 → NP_001272824.1  calreticulin 4 isoform a precursor

      See identical proteins and their annotated locations for NP_001272824.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (a).
      Source sequence(s)
      AK139540, AL627103, BG083829, JN255799
      UniProtKB/TrEMBL
      G5CPP0
      Conserved Domains (1) summary
      pfam00262
      Location:28 → 337
      Calreticulin; Calreticulin family

    3. NM_001285896.1 → NP_001272825.1  calreticulin 4 isoform c

      See identical proteins and their annotated locations for NP_001272825.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) has alternate 5' exon structure and it thus differs in the 5' UTR and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (c) is shorter at the N-terminus, compared to isoform a. Variants 3, 4 and 5 all encode isoform c.
      Source sequence(s)
      AK077094, AK139540, BG083829
      Consensus CDS
      CCDS71441.1
      UniProtKB/TrEMBL
      A2A8Z3
      Related
      ENSMUSP00000102240.2, ENSMUST00000106629.8
      Conserved Domains (1) summary
      pfam00262
      Location:1 → 211
      Calreticulin; Calreticulin family

    4. NM_001285897.1 → NP_001272826.1  calreticulin 4 isoform c

      See identical proteins and their annotated locations for NP_001272826.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) has alternate 5' exon structure and it thus differs in the 5' UTR and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (c) is shorter at the N-terminus, compared to isoform a. Variants 3, 4 and 5 all encode isoform c.
      Source sequence(s)
      AK077094, AK139540, AL627103, BG083829
      Consensus CDS
      CCDS71441.1
      UniProtKB/TrEMBL
      A2A8Z3
      Related
      ENSMUSP00000102239.2, ENSMUST00000106628.8
      Conserved Domains (1) summary
      pfam00262
      Location:1 → 211
      Calreticulin; Calreticulin family

    5. NM_001285898.1 → NP_001272827.1  calreticulin 4 isoform c

      See identical proteins and their annotated locations for NP_001272827.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) has alternate 5' exon structure and it thus differs in the 5' UTR and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (c) is shorter at the N-terminus, compared to isoform a. Variants 3, 4 and 5 all encode isoform c.
      Source sequence(s)
      AK077094, AK139540, AL627103, BG083829
      Consensus CDS
      CCDS71441.1
      UniProtKB/TrEMBL
      A2A8Z3
      Related
      ENSMUSP00000102242.3, ENSMUST00000106631.9
      Conserved Domains (1) summary
      pfam00262
      Location:1 → 211
      Calreticulin; Calreticulin family

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      109075610..109112176
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036163569.1 → XP_036019462.1  calreticulin 4 isoform X2

      Conserved Domains (1) summary
      pfam00262
      Location:7 → 308
      Calreticulin; Calreticulin family

    2. XM_017319911.3 → XP_017175400.2  calreticulin 4 isoform X1

      Conserved Domains (1) summary
      pfam00262
      Location:103 → 403
      Calreticulin; Calreticulin family

    3. XM_030253072.2 → XP_030108932.1  calreticulin 4 isoform X3

      Conserved Domains (1) summary
      pfam00262
      Location:44 → 141
      Calreticulin; Calreticulin family
    Nucleotide Protein Strain
    Heading Accession and Version

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