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    PPP1R14A protein phosphatase 1 regulatory inhibitor subunit 14A [ Sus scrofa (pig) ]

    Gene ID: 397610, updated on 17-Aug-2024

    Summary

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    Official Symbol
    PPP1R14Aprovided by VGNC
    Official Full Name
    protein phosphatase 1 regulatory inhibitor subunit 14Aprovided by VGNC
    Primary source
    VGNC:VGNC:98539
    See related
    Ensembl:ENSSSCG00000038077
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Sus scrofa
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus
    Also known as
    CPI17
    Expression
    Broad expression in lung (RPKM 29.6), mixtures (RPKM 10.5) and 8 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See PPP1R14A in Genome Data Viewer
    Location:
    chromosome: 6
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    106 current Sscrofa11.1 (GCF_000003025.6) 6 NC_010448.4 (47167105..47174299, complement)
    105 previous assembly Sscrofa10.2 (GCF_000003025.5) 6 NC_010448.3 (42669944..42674708, complement)

    Chromosome 6 - NC_010448.4Genomic Context describing neighboring genes Neighboring gene signal induced proliferation associated 1 like 3 Neighboring gene uncharacterized LOC110260981 Neighboring gene double PHD fingers 1 Neighboring gene serine peptidase inhibitor, Kunitz type 2 Neighboring gene uncharacterized LOC102167359 Neighboring gene chromosome 6 C19orf33 homolog

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Transcriptome data used for gene annotation
    • Description: Nine kinds of tissues and a mixture of multiple tissues were sequenced for genome annotation
    • BioProject: PRJNA311523
    • Publication: PMID 27646534
    • Analysis date: Thu Dec 14 17:10:49 2017

    Bibliography

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    Related articles in PubMed

    1. Distinctive solution conformation of phosphatase inhibitor CPI-17 substituted with aspartate at the phosphorylation-site threonine residue. Ohki Sy, et al. J Mol Biol, 2003 Mar 7. PMID 12595264
    2. Solution NMR structure of the myosin phosphatase inhibitor protein CPI-17 shows phosphorylation-induced conformational changes responsible for activation. Ohki S, et al. J Mol Biol, 2001 Dec 7. PMID 11734001
    3. Defining the structural determinants and a potential mechanism for inhibition of myosin phosphatase by the protein kinase C-potentiated inhibitor protein of 17 kDa. Hayashi Y, et al. J Biol Chem, 2001 Oct 26. PMID 11517233
    4. Tonic and phasic smooth muscle contraction is not regulated by the PKCα - CPI-17 pathway in swine stomach antrum and fundus. Zhang Y, et al. PLoS One, 2013. PMID 24058600, Free PMC Article
    5. Phosphorylation-induced conformational switching of CPI-17 produces a potent myosin phosphatase inhibitor. Eto M, et al. Structure, 2007 Dec. PMID 18073109, Free PMC Article

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. This study examined the protein expression and spatial-temporal distribution of PKCalpha and CPI-17 in intact smooth muscle tissues.
      Title: Tonic and phasic smooth muscle contraction is not regulated by the PKCα - CPI-17 pathway in swine stomach antrum and fundus.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables protein serine/threonine phosphatase inhibitor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in regulation of phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    protein phosphatase 1 regulatory subunit 14A
    Names
    17-kDa PKC-potentiated inhibitory protein of PP1
    CPI-17
    protein kinase C-potentiated inhibitor protein of 17 kDa

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_214337.1 → NP_999502.1  protein phosphatase 1 regulatory subunit 14A

      See identical proteins and their annotated locations for NP_999502.1

      Status: PROVISIONAL

      Source sequence(s)
      AB008376
      UniProtKB/Swiss-Prot
      O18734, Q9TQZ8, Q9TQZ9, Q9TR00, Q9TR01, Q9TR02
      UniProtKB/TrEMBL
      A0A287A3G0
      Related
      ENSSSCP00000078517.1, ENSSSCT00000094828.1
      Conserved Domains (1) summary
      pfam05361
      Location:1 → 128
      PP1_inhibitor; PKC-activated protein phosphatase-1 inhibitor

    RefSeqs of Annotated Genomes: Sus scrofa Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Sscrofa11.1 Primary Assembly

    Genomic

    1. NC_010448.4 Reference Sscrofa11.1 Primary Assembly

      Range
      47167105..47174299 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_021093577.1 → XP_020949236.1  protein phosphatase 1 regulatory subunit 14A isoform X1

      UniProtKB/TrEMBL
      A0A8D0XF34
      Conserved Domains (1) summary
      pfam05361
      Location:1 → 117
      PP1_inhibitor; PKC-activated protein phosphatase-1 inhibitor
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O18734.1 GenPept UniProtKB/Swiss-Prot:O18734

    Gene LinkOut

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