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    grid2 glutamate receptor, ionotropic, delta 2 [ Danio rerio (zebrafish) ]

    Gene ID: 448841, updated on 14-Nov-2024

    Summary

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    Official Symbol
    grid2provided by ZNC
    Official Full Name
    glutamate receptor, ionotropic, delta 2provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040913-1
    See related
    Ensembl:ENSDARG00000055302 AllianceGenome:ZFIN:ZDB-GENE-040913-1
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    GluD2; glurd2; si:rp71-1l7.1
    Summary
    Predicted to enable glutamate-gated receptor activity and transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential. Predicted to be involved in glutamatergic synaptic transmission and modulation of chemical synaptic transmission. Predicted to act upstream of or within ionotropic glutamate receptor signaling pathway. Predicted to be located in postsynaptic membrane. Predicted to be active in postsynaptic density membrane. Is expressed in brain and head. Human ortholog(s) of this gene implicated in autosomal recessive spinocerebellar ataxia 18. Orthologous to human GRID2 (glutamate ionotropic receptor delta type subunit 2). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See grid2 in Genome Data Viewer
    Location:
    chromosome: 8
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 8 NC_007119.7 (28900677..29587703)
    105 previous assembly GRCz10 (GCF_000002035.5) 8 NC_007119.6 (28891413..29578471)

    Chromosome 8 - NC_007119.7Genomic Context describing neighboring genes Neighboring gene osteoclast stimulatory transmembrane protein Neighboring gene coiled-coil serine-rich protein 1 Neighboring gene uncharacterized LOC137490334 Neighboring gene SNF2 related chromatin remodeling ATPase with DExD box 1a Neighboring gene atonal bHLH transcription factor 1a

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Expression of zebrafish glutamate receptor delta2 in neurons with cerebellum-like wiring. Mikami Y, et al. Biochem Biophys Res Commun, 2004 Sep 10. PMID 15313188
    2. Expression of zebrafish ROR alpha gene in cerebellar-like structures. Katsuyama Y, et al. Dev Dyn, 2007 Sep. PMID 17685489
    3. A nop56 Zebrafish Loss-of-Function Model Exhibits a Severe Neurodegenerative Phenotype. Quelle-Regaldie A, et al. Biomedicines, 2022 Jul 28. PMID 36009362, Free PMC Article
    4. Loss of smarcad1a accelerates tumorigenesis of malignant peripheral nerve sheath tumors in zebrafish. Han H, et al. Genes Chromosomes Cancer, 2021 Nov. PMID 34296799, Free PMC Article
    5. Role of neurexin2a in lead-induced locomotor defect in developing zebrafish. Tu H, et al. Aquat Toxicol, 2018 Jan. PMID 29195096

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables AMPA glutamate receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables glutamate-gated receptor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables ligand-gated monoatomic ion channel activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables monoatomic ion channel activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables signaling receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within ionotropic glutamate receptor signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in modulation of chemical synaptic transmission IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within monoatomic ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within monoatomic ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in synaptic transmission, glutamatergic IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of AMPA glutamate receptor complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in dendritic spine IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    is_active_in postsynaptic density membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in postsynaptic membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in synapse IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    glutamate receptor ionotropic, delta-2
    Names
    gluR delta-2 subunit
    glutamate receptor delta-2 subunit

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001004123.1 → NP_001004123.1  glutamate receptor ionotropic, delta-2 precursor

      See identical proteins and their annotated locations for NP_001004123.1

      Status: PROVISIONAL

      Source sequence(s)
      AB154207
      UniProtKB/Swiss-Prot
      Q68Y21
      Related
      ENSDARP00000116997.1, ENSDART00000141634.3
      Conserved Domains (4) summary
      cd06391
      Location:28 → 427
      PBP1_iGluR_delta_2; N-terminal leucine/isoleucine/valine-binding protein (LIVBP)-like domain of the delta2 receptor of an orphan glutamate receptor family
      cd13731
      Location:440 → 806
      PBP2_iGluR_delta_2; The ligand-binding domain of an orphan ionotropic glutamate receptor delta-2, a member of the type 2 periplasmic-binding fold protein superfamily
      pfam00060
      Location:568 → 841
      Lig_chan; Ligand-gated ion channel
      pfam01094
      Location:42 → 404
      ANF_receptor; Receptor family ligand binding region

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007119.7 Reference GRCz11 Primary Assembly

      Range
      28900677..29587703
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005167161.5 → XP_005167218.1  glutamate receptor ionotropic, delta-2 isoform X1

      UniProtKB/TrEMBL
      A0A8M2BEL3
      Conserved Domains (4) summary
      cd06391
      Location:28 → 427
      PBP1_iGluR_delta_2; N-terminal leucine/isoleucine/valine-binding protein (LIVBP)-like domain of the delta2 receptor of an orphan glutamate receptor family
      cd13731
      Location:440 → 806
      PBP2_iGluR_delta_2; The ligand-binding domain of an orphan ionotropic glutamate receptor delta-2, a member of the type 2 periplasmic-binding fold protein superfamily
      pfam00060
      Location:568 → 841
      Lig_chan; Ligand-gated ion channel
      pfam01094
      Location:42 → 404
      ANF_receptor; Receptor family ligand binding region

    2. XM_009304051.4 → XP_009302326.1  glutamate receptor ionotropic, delta-2 isoform X2

      UniProtKB/TrEMBL
      A0A8M3B4Y9
      Conserved Domains (4) summary
      cd06391
      Location:28 → 427
      PBP1_iGluR_delta_2; N-terminal leucine/isoleucine/valine-binding protein (LIVBP)-like domain of the delta2 receptor of an orphan glutamate receptor family
      cd13731
      Location:440 → 806
      PBP2_iGluR_delta_2; The ligand-binding domain of an orphan ionotropic glutamate receptor delta-2, a member of the type 2 periplasmic-binding fold protein superfamily
      pfam00060
      Location:568 → 841
      Lig_chan; Ligand-gated ion channel
      pfam01094
      Location:42 → 404
      ANF_receptor; Receptor family ligand binding region

    RNA

    1. XR_002459338.2 RNA Sequence

    Reference GRCz11 ALT_DRER_TU_1

    Genomic

    1. NW_018394728.1 Reference GRCz11 ALT_DRER_TU_1

      Range
      260278..260918
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCz11 ALT_DRER_TU_1

    Genomic

    1. NW_018394729.1 Reference GRCz11 ALT_DRER_TU_1

      Range
      10221..332323
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCz11 ALT_DRER_TU_2

    Genomic

    1. NW_018395274.1 Reference GRCz11 ALT_DRER_TU_2

      Range
      43200..87905
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q68Y21.1 GenPept UniProtKB/Swiss-Prot:Q68Y21

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