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    LIG4 ligase IV, DNA, ATP-dependent [ Latimeria chalumnae (coelacanth) ]

    Gene ID: 102363313, updated on 26-Apr-2024

    Summary

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    Gene symbol
    LIG4
    Gene description
    ligase IV, DNA, ATP-dependent
    See related
    Ensembl:ENSLACG00000003282
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Latimeria chalumnae
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Coelacanthiformes; Coelacanthidae; Latimeria
    Orthologs
    human zebrafish all
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    Genomic context

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    See LIG4 in Genome Data Viewer
    Location:
    chromosome: 4
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_04 current fLatCha1.pri (GCF_037176945.1) 4 NC_088142.1 (114817513..114828635)
    101 previous assembly LatCha1 (GCF_000225785.1) Unplaced Scaffold NW_005819362.1 (76961..87761, complement)

    Chromosome 4 - NC_088142.1Genomic Context describing neighboring genes Neighboring gene TNF superfamily member 13b Neighboring gene abhydrolase domain containing 13 Neighboring gene NALCN channel auxiliary factor 1 Neighboring gene uncharacterized LOC102358506 Neighboring gene arginine and glutamate rich 1a

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    2. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables DNA ligase (ATP) activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in DNA biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in DNA ligation involved in DNA repair IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in double-strand break repair via nonhomologous end joining IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in immunoglobulin V(D)J recombination IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in nucleotide-excision repair, DNA gap filling IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of DNA ligase IV complex IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    part_of DNA-dependent protein kinase-DNA ligase 4 complex IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    DNA ligase 4

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_037176945.1-RS_2024_04

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference fLatCha1.pri

    Genomic

    1. NC_088142.1 Reference fLatCha1.pri

      Range
      114817513..114828635
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005996998.3 → XP_005997060.1  DNA ligase 4

      See identical proteins and their annotated locations for XP_005997060.1

      UniProtKB/TrEMBL
      H3A217
      Conserved Domains (7) summary
      cd07968
      Location:464 → 601
      OBF_DNA_ligase_IV; The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase IV is a DNA-binding module that is part of the catalytic core unit
      cd07903
      Location:240 → 461
      Adenylation_DNA_ligase_IV; Adenylation domain of DNA Ligase IV
      cd00027
      Location:845 → 899
      BRCT; Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo ...
      TIGR00574
      Location:86 → 607
      dnl1; DNA ligase I, ATP-dependent (dnl1)
      pfam00533
      Location:657 → 733
      BRCT; BRCA1 C Terminus (BRCT) domain
      pfam04675
      Location:20 → 208
      DNA_ligase_A_N; DNA ligase N terminus
      pfam11411
      Location:753 → 786
      DNA_ligase_IV; DNA ligase IV

    2. XM_005996999.3 → XP_005997061.1  DNA ligase 4

      See identical proteins and their annotated locations for XP_005997061.1

      UniProtKB/TrEMBL
      H3A217
      Related
      ENSLACP00000003688.1
      Conserved Domains (7) summary
      cd07968
      Location:464 → 601
      OBF_DNA_ligase_IV; The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase IV is a DNA-binding module that is part of the catalytic core unit
      cd07903
      Location:240 → 461
      Adenylation_DNA_ligase_IV; Adenylation domain of DNA Ligase IV
      cd00027
      Location:845 → 899
      BRCT; Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo ...
      TIGR00574
      Location:86 → 607
      dnl1; DNA ligase I, ATP-dependent (dnl1)
      pfam00533
      Location:657 → 733
      BRCT; BRCA1 C Terminus (BRCT) domain
      pfam04675
      Location:20 → 208
      DNA_ligase_A_N; DNA ligase N terminus
      pfam11411
      Location:753 → 786
      DNA_ligase_IV; DNA ligase IV
    Nucleotide Protein
    Heading Accession and Version

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