Mapk7 mitogen-activated protein kinase 7 [Rattus norvegicus (Norway rat)] - Gene

Summary

Symbol: Mapk7provided by RGD
Full Name: mitogen-activated protein kinase 7provided by RGD
Primary source: RGD:621505
See related: EnsemblRapid:ENSRNOG00000047907 AllianceGenome:RGD:621505
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Bmk1; Erk5; Prkm7
Summary: Enables ATP binding activity and MAP kinase activity. Involved in ERK5 cascade; negative regulation of smooth muscle cell apoptotic process; and protein autophosphorylation. Predicted to be located in PML body and cytosol. Predicted to be active in cytoplasm and nucleus. Orthologous to human MAPK7 (mitogen-activated protein kinase 7). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Lung (RPKM 30.3), Testes (RPKM 29.4) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 10q22

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	10	NC_086028.1 (46669721..46675768, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	10	NC_051345.1 (46170264..46176262, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	10	NC_005109.4 (47768592..47775130, complement)

Chromosome 10 - NC_086028.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The MAP kinase ERK5/MAPK7 is a downstream effector of oxytocin signaling in myometrial cells.
Title: The MAP kinase ERK5/MAPK7 is a downstream effector of oxytocin signaling in myometrial cells.
Extracellular regulated kinase 5 mediates osteoporosis through modulating viability and apoptosis of osteoblasts in ovariectomized rats.
Title: Extracellular regulated kinase 5 mediates osteoporosis through modulating viability and apoptosis of osteoblasts in ovariectomized rats.
Study revealed that ERK5 signaling promotes phosphorylation of Kv4.2 and inhibits the inactivation of the A-type current for the enhancement of membrane excitability in PC12 cells. ERK5 promotes neurite outgrowth and catecholamine biosynthesis.
Title: ERK5 Phosphorylates K(v)4.2 and Inhibits Inactivation of the A-Type Current in PC12 Cells.
Erk5 role in the cardiac mitochondria and the Pgc-1alpha regulation
Title: Metabolic stress-induced cardiomyopathy is caused by mitochondrial dysfunction due to attenuated Erk5 signaling.
ERK5 signaling is required for catecholamine biosynthesis during neural differentiation, in part to induce ankrd1, and to maintain appropriate TH levels.
Title: ERK5 induces ankrd1 for catecholamine biosynthesis and homeostasis in adrenal medullary cells.
Activation of ERK5 in cerebrospinal fluid-contacting nucleus contributes to the development of neuropathic pain.
Title: Extracellular Signal-Regulated Kinase 5 in the Cerebrospinal Fluid-Contacting Nucleus Contributes to Neuropathic Pain in Rats.
Phosphorylation of ERK5 on Thr732 is associated with ERK5 nuclear localization and ERK5-dependent transcription
Title: Phosphorylation of ERK5 on Thr732 is associated with ERK5 nuclear localization and ERK5-dependent transcription.
not only does ERK5 have differential mediation of insulin and TNFalpha-stimulated VCAM-1 expression, but also has differential regulation of insulin plus TNFalpha-stimulated total and surface VCAM-1 expression
Title: Extracellular signal-regulated kinase-5: Novel mediator of insulin and tumor necrosis factor α-stimulated vascular cell adhesion molecule-1 expression in vascular cells.
Data indicate that NSC23766-mediated Rac inhibition induces cerebellar granule neurons (CGNs) apoptosis through deactivation of prosurvival MAP Kinase Kinase 5 MEK5/ERK5 kinase signaling.
Title: Neuronal apoptosis induced by selective inhibition of Rac GTPase versus global suppression of Rho family GTPases is mediated by alterations in distinct mitogen-activated protein kinase signaling cascades.
It plays distinct role in proliferation, differentiation, and neuronal viability.
Title: Role of ERK1, 2, and 5 in dopamine neuron survival during aging.

Submit: New GeneRIF Correction See all GeneRIFs (47)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH129756 (e-PCR)
- UniSTS:213049

UniSTS:469818 (e-PCR)
- UniSTS:469818

Mapk7 (e-PCR), detects polymorphism
- UniSTS:469818

G67083 (e-PCR)
- UniSTS:178292

RH141658 (e-PCR)
- UniSTS:223651

STS-U29725 (e-PCR)
- UniSTS:72402

Mapk7 (e-PCR), detects polymorphism
- UniSTS:516574

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ATP binding	IDA Inferred from Direct Assay more info	PubMed
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables JUN kinase activity	IEA Inferred from Electronic Annotation more info
enables MAP kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables MAP kinase activity	IEA Inferred from Electronic Annotation more info
enables mitogen-activated protein kinase binding	IEA Inferred from Electronic Annotation more info
enables mitogen-activated protein kinase binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase activity	ISO Inferred from Sequence Orthology more info
enables protein serine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein serine/threonine kinase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in ERK5 cascade	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in JNK cascade	IEA Inferred from Electronic Annotation more info
involved_in MAPK cascade	IEA Inferred from Electronic Annotation more info
involved_in MAPK cascade	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in calcineurin-NFAT signaling cascade	IEA Inferred from Electronic Annotation more info
acts_upstream_of calcineurin-NFAT signaling cascade	ISO Inferred from Sequence Orthology more info
involved_in cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in cellular response to growth factor stimulus	ISO Inferred from Sequence Orthology more info
involved_in cellular response to hydrogen peroxide	IEA Inferred from Electronic Annotation more info
involved_in cellular response to hydrogen peroxide	ISO Inferred from Sequence Orthology more info
involved_in cellular response to laminar fluid shear stress	IEA Inferred from Electronic Annotation more info
involved_in cellular response to laminar fluid shear stress	ISO Inferred from Sequence Orthology more info
involved_in cellular response to transforming growth factor beta stimulus	IEA Inferred from Electronic Annotation more info
involved_in cellular response to transforming growth factor beta stimulus	ISO Inferred from Sequence Orthology more info
involved_in intracellular signal transduction	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within negative regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of calcineurin-NFAT signaling cascade	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of calcineurin-NFAT signaling cascade	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of endothelial cell apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of endothelial cell apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of extrinsic apoptotic signaling pathway in absence of ligand	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of extrinsic apoptotic signaling pathway in absence of ligand	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of heterotypic cell-cell adhesion	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of heterotypic cell-cell adhesion	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of response to cytokine stimulus	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of response to cytokine stimulus	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of smooth muscle cell apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within peptidyl-serine phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein metabolic process	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of protein metabolic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in protein autophosphorylation	IDA Inferred from Direct Assay more info	PubMed
involved_in protein phosphorylation	IDA Inferred from Direct Assay more info	PubMed
involved_in protein phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in regulation of angiogenesis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of angiogenesis	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in PML body	IEA Inferred from Electronic Annotation more info
located_in PML body	ISO Inferred from Sequence Orthology more info
located_in PML body	ISS Inferred from Sequence or Structural Similarity more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: mitogen-activated protein kinase 7

Names: BMK-1; BMK1 kinase; ERK-5; MAP kinase 7; MAPK 7; big MAP kinase 1; extracellular signal-regulated kinase 5

NP_001178476.1

EC 2.7.11.24

XP_006246479.1

EC 2.7.11.24

XP_006246480.1

EC 2.7.11.24

XP_006246482.1

EC 2.7.11.24

XP_008765978.1

EC 2.7.11.24

XP_038940964.1

EC 2.7.11.24

XP_063124344.1

EC 2.7.11.24

XP_063124345.1

EC 2.7.11.24

XP_063124346.1

EC 2.7.11.24

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001191547.1 → NP_001178476.1 mitogen-activated protein kinase 7

See identical proteins and their annotated locations for NP_001178476.1

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000010

UniProtKB/Swiss-Prot

P0C865

UniProtKB/TrEMBL

E9PTH2

Conserved Domains (1) summary

cd07855
Location:49 → 384

STKc_ERK5; Catalytic domain of the Serine/Threonine Kinase, Extracellular signal-Regulated Kinase 5

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086028.1 Reference GRCr8

Range

46669721..46675768 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006246418.5 → XP_006246480.1 mitogen-activated protein kinase 7 isoform X1

See identical proteins and their annotated locations for XP_006246480.1

UniProtKB/Swiss-Prot

P0C865

UniProtKB/TrEMBL

E9PTH2

Related

ENSRNOP00000079913.2, ENSRNOT00000111246.2

Conserved Domains (1) summary

cd07855
Location:49 → 384

STKc_ERK5; Catalytic domain of the Serine/Threonine Kinase, Extracellular signal-Regulated Kinase 5
XM_063268276.1 → XP_063124346.1 mitogen-activated protein kinase 7 isoform X2

UniProtKB/Swiss-Prot

P0C865
XM_063268274.1 → XP_063124344.1 mitogen-activated protein kinase 7 isoform X1

UniProtKB/Swiss-Prot

P0C865

UniProtKB/TrEMBL

E9PTH2
XM_063268275.1 → XP_063124345.1 mitogen-activated protein kinase 7 isoform X2

UniProtKB/Swiss-Prot

P0C865
XM_006246417.5 → XP_006246479.1 mitogen-activated protein kinase 7 isoform X1

See identical proteins and their annotated locations for XP_006246479.1

UniProtKB/Swiss-Prot

P0C865

UniProtKB/TrEMBL

E9PTH2

Related

ENSRNOP00000064205.3, ENSRNOT00000072970.4

Conserved Domains (1) summary

cd07855
Location:49 → 384

STKc_ERK5; Catalytic domain of the Serine/Threonine Kinase, Extracellular signal-Regulated Kinase 5
XM_006246420.5 → XP_006246482.1 mitogen-activated protein kinase 7 isoform X2

See identical proteins and their annotated locations for XP_006246482.1

UniProtKB/Swiss-Prot

P0C865

Conserved Domains (1) summary

cl21453
Location:1 → 245

PKc_like; Protein Kinases, catalytic domain
XM_008767756.4 → XP_008765978.1 mitogen-activated protein kinase 7 isoform X2

See identical proteins and their annotated locations for XP_008765978.1

UniProtKB/Swiss-Prot

P0C865

Conserved Domains (1) summary

cl21453
Location:1 → 245

PKc_like; Protein Kinases, catalytic domain
XM_039085036.2 → XP_038940964.1 mitogen-activated protein kinase 7 isoform X2

UniProtKB/Swiss-Prot

P0C865

Conserved Domains (1) summary

cl21453
Location:1 → 245

PKc_like; Protein Kinases, catalytic domain