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    Osbpl11 oxysterol binding protein-like 11 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 303888, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Osbpl11provided by RGD
    Official Full Name
    oxysterol binding protein-like 11provided by RGD
    Primary source
    RGD:1307294
    See related
    EnsemblRapid:ENSRNOG00000001782 AllianceGenome:RGD:1307294
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable sterol binding activity. Predicted to be involved in fat cell differentiation and positive regulation of sequestering of triglyceride. Predicted to be located in nucleoplasm. Predicted to be active in Golgi apparatus; cytosol; and membrane. Orthologous to human OSBPL11 (oxysterol binding protein like 11). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Liver (RPKM 187.6), Thymus (RPKM 153.5) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Osbpl11 in Genome Data Viewer
    Location:
    11q22
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 11 NC_086029.1 (81038759..81121887, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 11 NC_051346.1 (67533669..67616795, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 11 NC_005110.4 (70770509..70855425, complement)

    Chromosome 11 - NC_086029.1Genomic Context describing neighboring genes Neighboring gene sorting nexin 4 Neighboring gene uncharacterized LOC120095666 Neighboring gene uncharacterized LOC134481083 Neighboring gene leishmanolysin like peptidase Neighboring gene ribosomal protein L35A

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. OSBP-related proteins (ORPs) in human adipose depots and cultured adipocytes: evidence for impacts on the adipocyte phenotype. Zhou Y, et al. PLoS One, 2012. PMID 23028956, Free PMC Article
    2. p38α MAPK proximity assay reveals a regulatory mechanism of alternative splicing in cardiomyocytes. Dumont AA, et al. Biochim Biophys Acta Mol Cell Res, 2019 Dec. PMID 31505169
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in fat cell differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in lipid transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of sequestering of triglyceride ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    oxysterol-binding protein-related protein 11

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001107090.2 → NP_001100560.1  oxysterol-binding protein-related protein 11

      See identical proteins and their annotated locations for NP_001100560.1

      Status: PROVISIONAL

      Source sequence(s)
      BC168952
      UniProtKB/TrEMBL
      A6IRL8, B5DF74, F7FPV5
      Related
      ENSRNOP00000002428.5, ENSRNOT00000002428.8
      Conserved Domains (3) summary
      cd13291
      Location:72 → 178
      PH_ORP10_ORP11; Human Oxysterol binding protein (OSBP) related proteins 10 and 11 (ORP10 and ORP11) Pleckstrin homology (PH) domain
      pfam00169
      Location:74 → 164
      PH; PH domain
      pfam01237
      Location:380 → 740
      Oxysterol_BP; Oxysterol-binding protein

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086029.1 Reference GRCr8

      Range
      81038759..81121887 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006248451.5 → XP_006248513.1  oxysterol-binding protein-related protein 11 isoform X3

      See identical proteins and their annotated locations for XP_006248513.1

      Conserved Domains (3) summary
      cd13291
      Location:4 → 110
      PH_ORP10_ORP11; Human Oxysterol binding protein (OSBP) related proteins 10 and 11 (ORP10 and ORP11) Pleckstrin homology (PH) domain
      pfam00169
      Location:6 → 96
      PH; PH domain
      pfam01237
      Location:312 → 672
      Oxysterol_BP; Oxysterol-binding protein

    2. XM_006248450.5 → XP_006248512.1  oxysterol-binding protein-related protein 11 isoform X2

      UniProtKB/TrEMBL
      A0A8I6A240
      Related
      ENSRNOP00000085645.1, ENSRNOT00000104334.2
      Conserved Domains (3) summary
      cd13291
      Location:72 → 174
      PH_ORP10_ORP11; Human Oxysterol binding protein (OSBP) related proteins 10 and 11 (ORP10 and ORP11) Pleckstrin homology (PH) domain
      pfam00169
      Location:74 → 164
      PH; PH domain
      pfam01237
      Location:321 → 681
      Oxysterol_BP; Oxysterol-binding protein

    3. XM_063270516.1 → XP_063126586.1  oxysterol-binding protein-related protein 11 isoform X3

    4. XM_006248452.4 → XP_006248514.1  oxysterol-binding protein-related protein 11 isoform X3

      See identical proteins and their annotated locations for XP_006248514.1

      Conserved Domains (3) summary
      cd13291
      Location:4 → 110
      PH_ORP10_ORP11; Human Oxysterol binding protein (OSBP) related proteins 10 and 11 (ORP10 and ORP11) Pleckstrin homology (PH) domain
      pfam00169
      Location:6 → 96
      PH; PH domain
      pfam01237
      Location:312 → 672
      Oxysterol_BP; Oxysterol-binding protein

    5. XM_063270515.1 → XP_063126585.1  oxysterol-binding protein-related protein 11 isoform X1

    Nucleotide Protein Strain
    Heading Accession and Version

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