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    Cd46 CD46 molecule [ Rattus norvegicus (Norway rat) ]

    Gene ID: 29333, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Cd46provided by RGD
    Official Full Name
    CD46 moleculeprovided by RGD
    Primary source
    RGD:3061
    See related
    AllianceGenome:RGD:3061
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Mcp
    Summary
    Contributes to endopeptidase activity. Involved in positive regulation of proteolysis. Located in basolateral plasma membrane; cell surface; and inner acrosomal membrane. Biomarker of acute necrotizing pancreatitis. Human ortholog(s) of this gene implicated in several diseases, including atypical hemolytic-uremic syndrome; hemolytic-uremic syndrome; meningococcal meningitis; multiple sclerosis; and pre-eclampsia. Orthologous to human CD46 (CD46 molecule). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Lung (RPKM 28.9), Thymus (RPKM 26.9) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Cd46 in Genome Data Viewer
    Location:
    13q27
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 13 NC_086031.1 (109104122..109134903, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 13 NC_051348.1 (106575586..106606325, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 13 NC_005112.4 (113786525..113818741, complement)

    Chromosome 13 - NC_086031.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102550527 Neighboring gene microRNA 3556b Neighboring gene microRNA 29b-2 Neighboring gene microRNA 29c Neighboring gene uncharacterized LOC108352604 Neighboring gene complement C3b/C4b receptor 1 like Neighboring gene complement C3d receptor 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Oncolytic measles virus targets high CD46 expression on multiple myeloma cells. Ong HT, et al. Exp Hematol, 2006 Jun. PMID 16728275
    2. High expression of the antigen recognized by the monoclonal antibody GB24 on human breast carcinomas: a preventive mechanism of malignant tumor cells against complement attack? Hofman P, et al. Breast Cancer Res Treat, 1994. PMID 7532466
    3. Expression of decay-accelerating factor (CD55), membrane cofactor protein (CD46) and CD59 in the human astroglioma cell line, D54-MG, and primary rat astrocytes. Yang C, et al. J Neuroimmunol, 1993 Sep. PMID 7690370
    4. Molecular cloning, expression and characterization of the rat analogue of human membrane cofactor protein (MCP/CD46). Mead R, et al. Immunology, 1999 Sep. PMID 10469244, Free PMC Article
    5. A possible role of CD46 for the protection in vivo of human renal tumor cells from complement-mediated damage. Blok VT, et al. Lab Invest, 2000 Mar. PMID 10744069

    See all (43) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables cadherin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    contributes_to endopeptidase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables endopeptidase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in T cell mediated immunity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in T cell mediated immunity ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of complement activation, alternative pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of complement activation, classical pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of complement activation, classical pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of T cell proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of interleukin-10 production ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of memory T cell differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of proteolysis IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of regulatory T cell differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of transforming growth factor beta production ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in proteolysis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of Notch signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in sequestering of extracellular ligand from receptor ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in single fertilization IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in acrosomal vesicle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in basolateral plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    NOT located_in cell surface IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cell surface IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cell surface IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cell surface ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in inner acrosomal membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in inner acrosomal membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    membrane cofactor protein
    Names
    CD46 antigen, complement regulatory protein
    CD46 molecule, complement regulatory protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_019190.1 → NP_062063.1  membrane cofactor protein precursor

      See identical proteins and their annotated locations for NP_062063.1

      Status: PROVISIONAL

      Source sequence(s)
      AB010920
      UniProtKB/Swiss-Prot
      Q9Z0M4
      UniProtKB/TrEMBL
      A0A8I5ZTV7, A6JH46
      Conserved Domains (2) summary
      cd00033
      Location:171 → 233
      CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
      pfam00084
      Location:107 → 166
      Sushi; Sushi repeat (SCR repeat)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086031.1 Reference GRCr8

      Range
      109104122..109134903 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006250478.5 → XP_006250540.1  membrane cofactor protein isoform X2

      UniProtKB/TrEMBL
      A0A8I5ZMW2, A0A8I5ZTV7
      Conserved Domains (2) summary
      cd00033
      Location:171 → 233
      CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
      pfam00084
      Location:107 → 166
      Sushi; Sushi repeat (SCR repeat)

    2. XM_008769849.4 → XP_008768071.1  membrane cofactor protein isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZTV7, A0A8L2QSL3
      Conserved Domains (2) summary
      cd00033
      Location:171 → 233
      CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
      pfam00084
      Location:107 → 166
      Sushi; Sushi repeat (SCR repeat)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9Z0M4.1 GenPept UniProtKB/Swiss-Prot:Q9Z0M4

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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