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    Pde4c phosphodiesterase 4C [ Rattus norvegicus (Norway rat) ]

    Gene ID: 290646, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Pde4cprovided by RGD
    Official Full Name
    phosphodiesterase 4Cprovided by RGD
    Primary source
    RGD:727918
    See related
    EnsemblRapid:ENSRNOG00000019518 AllianceGenome:RGD:727918
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Dpde1
    Summary
    Predicted to enable 3',5'-cyclic-AMP phosphodiesterase activity and 3',5'-cyclic-GMP phosphodiesterase activity. Involved in negative regulation of insulin secretion involved in cellular response to glucose stimulus. Predicted to be located in cilium. Predicted to be active in cytosol; nucleus; and perinuclear region of cytoplasm. Orthologous to human PDE4C (phosphodiesterase 4C). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Kidney (RPKM 67.9), Heart (RPKM 30.3) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Pde4c in Genome Data Viewer
    Location:
    16p14
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 16 NC_086034.1 (18724703..18745528, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 16 NC_051351.1 (18690727..18711555, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 16 NC_005115.4 (20442305..20466386, complement)

    Chromosome 16 - NC_086034.1Genomic Context describing neighboring genes Neighboring gene IFI30, lysosomal thiol reductase Neighboring gene MPV17 mitochondrial inner membrane protein like 2 Neighboring gene RAB3A, member RAS oncogene family Neighboring gene colon, intestine and stomach enriched 1 Neighboring gene IQ motif containing N

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Phosphodiesterase 3 and 4 comprise the major cAMP metabolizing enzymes responsible for insulin secretion in INS-1 (832/13) cells and rat islets. Waddleton D, et al. Biochem Pharmacol, 2008 Oct 1. PMID 18706893
    2. Molecular cloning of rat homologues of the Drosophila melanogaster dunce cAMP phosphodiesterase: evidence for a family of genes. Swinnen JV, et al. Proc Natl Acad Sci U S A, 1989 Jul. PMID 2546153, Free PMC Article
    3. Differential CNS expression of alternative mRNA isoforms of the mammalian genes encoding cAMP-specific phosphodiesterases. Bolger GB, et al. Gene, 1994 Nov 18. PMID 7958996
    4. A phosphodiesterase 2A isoform localized to mitochondria regulates respiration. Acin-Perez R, et al. J Biol Chem, 2011 Sep 2. PMID 21724846, Free PMC Article
    5. Polycystin-2 and phosphodiesterase 4C are components of a ciliary A-kinase anchoring protein complex that is disrupted in cystic kidney diseases. Choi YH, et al. Proc Natl Acad Sci U S A, 2011 Jun 28. PMID 21670265, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Clone Names

    • MGC188426

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables 3',5'-cyclic-AMP phosphodiesterase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables 3',5'-cyclic-AMP phosphodiesterase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables 3',5'-cyclic-AMP phosphodiesterase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables 3',5'-cyclic-AMP phosphodiesterase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables 3',5'-cyclic-GMP phosphodiesterase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables 3',5'-cyclic-nucleotide phosphodiesterase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cAMP catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cAMP-mediated signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of insulin secretion involved in cellular response to glucose stimulus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cilium ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cilium ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    3',5'-cyclic-AMP phosphodiesterase 4C
    Names
    cAMP-specific 3',5'-cyclic phosphodiesterase 4C
    cAMP-specific 35-cyclic phosphodiesterase 4C
    cAMP-specific phosphodiesterase 4C
    phosphodiesterase 4C, cAMP-specific (phosphodiesterase E1 dunce homolog, Drosophila)
    NP_001263694.1
    XP_006252930.1
    XP_006252931.1
    XP_063131227.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001276765.1 → NP_001263694.1  3',5'-cyclic-AMP phosphodiesterase 4C

      See identical proteins and their annotated locations for NP_001263694.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000016
      UniProtKB/TrEMBL
      A6KA06, A6KA07, G3V8J8
      Related
      ENSRNOP00000026457.5, ENSRNOT00000026457.8
      Conserved Domains (1) summary
      pfam00233
      Location:388 → 629
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086034.1 Reference GRCr8

      Range
      18724703..18745528 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006252868.4 → XP_006252930.1  3',5'-cyclic-AMP phosphodiesterase 4C isoform X1

      See identical proteins and their annotated locations for XP_006252930.1

      UniProtKB/TrEMBL
      A6KA06, A6KA07, G3V8J8
      Conserved Domains (1) summary
      pfam00233
      Location:388 → 629
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase

    2. XM_006252869.5 → XP_006252931.1  3',5'-cyclic-AMP phosphodiesterase 4C isoform X2

      UniProtKB/TrEMBL
      A0A8I6AN21
      Related
      ENSRNOP00000096064.2, ENSRNOT00000113780.2
      Conserved Domains (1) summary
      pfam00233
      Location:348 → 589
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase

    3. XM_063275157.1 → XP_063131227.1  3',5'-cyclic-AMP phosphodiesterase 4C isoform X3

      UniProtKB/Swiss-Prot
      P14644
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P14644.2 GenPept UniProtKB/Swiss-Prot:P14644

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