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    Anks1a ankyrin repeat and sterile alpha motif domain containing 1A [ Rattus norvegicus (Norway rat) ]

    Gene ID: 309639, updated on 9-Dec-2024

    Summary

    Official Symbol
    Anks1aprovided by RGD
    Official Full Name
    ankyrin repeat and sterile alpha motif domain containing 1Aprovided by RGD
    Primary source
    RGD:1309183
    See related
    EnsemblRapid:ENSRNOG00000000498 AllianceGenome:RGD:1309183
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Anks1
    Summary
    Predicted to enable ephrin receptor binding activity. Predicted to be involved in ephrin receptor signaling pathway; neuron remodeling; and substrate-dependent cell migration. Predicted to act upstream of or within negative regulation of ubiquitin-dependent protein catabolic process and regulation of ephrin receptor signaling pathway. Predicted to be located in neuron projection and nucleoplasm. Predicted to be active in cytosol. Orthologous to human ANKS1A (ankyrin repeat and sterile alpha motif domain containing 1A). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Heart (RPKM 100.7), Lung (RPKM 87.0) and 9 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Anks1a in Genome Data Viewer
    Location:
    20p12
    Exon count:
    28
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 20 NC_086038.1 (5965421..6118875)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 20 NC_051355.1 (5963658..6117139)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 20 NC_005119.4 (7484550..7636498)

    Chromosome 20 - NC_086038.1Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA SNORA26 Neighboring gene bridge-like lipid transfer protein family member 3A Neighboring gene TATA-box binding protein associated factor 11 Neighboring gene uncharacterized LOC102552617 Neighboring gene uncharacterized LOC108349039 Neighboring gene t-complex 11 Neighboring gene uncharacterized LOC120098860

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ephrin receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables ephrin receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in neuron projection ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    ankyrin repeat and SAM domain-containing protein 1A
    Names
    ankyrin repeat and SAM domain containing 1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001107613.3NP_001101083.1  ankyrin repeat and SAM domain-containing protein 1A isoform 2

      See identical proteins and their annotated locations for NP_001101083.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000020
      UniProtKB/TrEMBL
      A6JJP3
      Conserved Domains (7) summary
      cd09499
      Location:688754
      SAM_AIDA1AB-like_repeat1; SAM domain of AIDA1AB-like proteins, repeat 1
      cd09500
      Location:759823
      SAM_AIDA1AB-like_repeat2; SAM domain of AIDA1AB-like proteins, repeat 2
      smart00454
      Location:691750
      SAM; Sterile alpha motif
      cd00204
      Location:71199
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd01274
      Location:9171062
      PTB_Anks; Ankyrin repeat and sterile alpha motif (SAM) domain-containing (Anks) protein family Phosphotyrosine-binding (PTB) domain
      pfam12796
      Location:183274
      Ank_2; Ankyrin repeats (3 copies)
      sd00045
      Location:77107
      ANK; ANK repeat [structural motif]
    2. NM_001414943.1NP_001401872.1  ankyrin repeat and SAM domain-containing protein 1A isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000020
      UniProtKB/TrEMBL
      D4AC12
      Related
      ENSRNOP00000048981.4, ENSRNOT00000044395.7

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086038.1 Reference GRCr8

      Range
      5965421..6118875
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006256193.5XP_006256255.1  ankyrin repeat and SAM domain-containing protein 1A isoform X1

      UniProtKB/TrEMBL
      A0A0G2K2G7
      Conserved Domains (7) summary
      cd09499
      Location:712778
      SAM_AIDA1AB-like_repeat1; SAM domain of AIDA1AB-like proteins, repeat 1
      cd09500
      Location:783847
      SAM_AIDA1AB-like_repeat2; SAM domain of AIDA1AB-like proteins, repeat 2
      smart00454
      Location:715774
      SAM; Sterile alpha motif
      cd00204
      Location:71220
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd01274
      Location:9411086
      PTB_Anks; Ankyrin repeat and sterile alpha motif (SAM) domain-containing (Anks) protein family Phosphotyrosine-binding (PTB) domain
      pfam12796
      Location:204295
      Ank_2; Ankyrin repeats (3 copies)
      sd00045
      Location:166197
      ANK; ANK repeat [structural motif]
    2. XM_039098686.2XP_038954614.1  ankyrin repeat and SAM domain-containing protein 1A isoform X2

      Related
      ENSRNOP00000094383.2, ENSRNOT00000107130.2
      Conserved Domains (6) summary
      cd09499
      Location:712778
      SAM_AIDA1AB-like_repeat1; SAM domain of AIDA1AB-like proteins, repeat 1
      cd09500
      Location:783847
      SAM_AIDA1AB-like_repeat2; SAM domain of AIDA1AB-like proteins, repeat 2
      PHA03095
      Location:67302
      PHA03095; ankyrin-like protein; Provisional
      cd01274
      Location:9411086
      PTB_Anks; Ankyrin repeat and sterile alpha motif (SAM) domain-containing (Anks) protein family Phosphotyrosine-binding (PTB) domain
      sd00045
      Location:166197
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:204295
      Ank_2; Ankyrin repeats (3 copies)
    3. XM_006256196.5XP_006256258.1  ankyrin repeat and SAM domain-containing protein 1A isoform X4

      Conserved Domains (7) summary
      cd09499
      Location:712778
      SAM_AIDA1AB-like_repeat1; SAM domain of AIDA1AB-like proteins, repeat 1
      cd09500
      Location:783847
      SAM_AIDA1AB-like_repeat2; SAM domain of AIDA1AB-like proteins, repeat 2
      smart00454
      Location:715774
      SAM; Sterile alpha motif
      cd00204
      Location:71220
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd01274
      Location:9411086
      PTB_Anks; Ankyrin repeat and sterile alpha motif (SAM) domain-containing (Anks) protein family Phosphotyrosine-binding (PTB) domain
      pfam12796
      Location:204295
      Ank_2; Ankyrin repeats (3 copies)
      sd00045
      Location:166197
      ANK; ANK repeat [structural motif]
    4. XM_006256195.5XP_006256257.1  ankyrin repeat and SAM domain-containing protein 1A isoform X3

      UniProtKB/TrEMBL
      A0A8I6AJG9
      Conserved Domains (7) summary
      cd09499
      Location:691757
      SAM_AIDA1AB-like_repeat1; SAM domain of AIDA1AB-like proteins, repeat 1
      cd09500
      Location:762826
      SAM_AIDA1AB-like_repeat2; SAM domain of AIDA1AB-like proteins, repeat 2
      smart00454
      Location:694753
      SAM; Sterile alpha motif
      cd00204
      Location:71199
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd01274
      Location:9201065
      PTB_Anks; Ankyrin repeat and sterile alpha motif (SAM) domain-containing (Anks) protein family Phosphotyrosine-binding (PTB) domain
      pfam12796
      Location:183274
      Ank_2; Ankyrin repeats (3 copies)
      sd00045
      Location:77107
      ANK; ANK repeat [structural motif]
    5. XM_006256197.5XP_006256259.1  ankyrin repeat and SAM domain-containing protein 1A isoform X5

      Related
      ENSRNOP00000108273.1, ENSRNOT00000152658.1
      Conserved Domains (7) summary
      cd09499
      Location:691757
      SAM_AIDA1AB-like_repeat1; SAM domain of AIDA1AB-like proteins, repeat 1
      cd09500
      Location:762826
      SAM_AIDA1AB-like_repeat2; SAM domain of AIDA1AB-like proteins, repeat 2
      smart00454
      Location:694753
      SAM; Sterile alpha motif
      cd00204
      Location:71199
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd01274
      Location:9201065
      PTB_Anks; Ankyrin repeat and sterile alpha motif (SAM) domain-containing (Anks) protein family Phosphotyrosine-binding (PTB) domain
      pfam12796
      Location:183274
      Ank_2; Ankyrin repeats (3 copies)
      sd00045
      Location:77107
      ANK; ANK repeat [structural motif]
    6. XM_063279124.1XP_063135194.1  ankyrin repeat and SAM domain-containing protein 1A isoform X6

      Related
      ENSRNOP00000072237.3, ENSRNOT00000081604.3
    7. XM_063279125.1XP_063135195.1  ankyrin repeat and SAM domain-containing protein 1A isoform X7

    8. XM_063279126.1XP_063135196.1  ankyrin repeat and SAM domain-containing protein 1A isoform X8

    9. XM_063279127.1XP_063135197.1  ankyrin repeat and SAM domain-containing protein 1A isoform X9

    RNA

    1. XR_010060683.1 RNA Sequence