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    Tns1 tensin 1 [ Mus musculus (house mouse) ]

    Gene ID: 21961, updated on 27-Nov-2024

    Summary

    Official Symbol
    Tns1provided by MGI
    Official Full Name
    tensin 1provided by MGI
    Primary source
    MGI:MGI:104552
    See related
    Ensembl:ENSMUSG00000055322 AllianceGenome:MGI:104552
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Tns; 1110018I21Rik; 1200014E20Rik; E030018G17Rik; E030037J05Rik
    Summary
    Predicted to enable actin binding activity. Acts upstream of or within cell-substrate junction assembly and fibroblast migration. Located in focal adhesion. Is expressed in several structures, including future brain; gut; heart; metanephros; and yolk sac. Orthologous to human TNS1 (tensin 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in lung adult (RPKM 128.6), bladder adult (RPKM 85.1) and 18 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Tns1 in Genome Data Viewer
    Location:
    1 C3; 1 38.17 cM
    Exon count:
    52
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (73949391..74163707, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (73910232..74124548, complement)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 6030407O03 gene Neighboring gene predicted gene 29183 Neighboring gene STARR-seq mESC enhancer starr_01316 Neighboring gene STARR-seq mESC enhancer starr_01317 Neighboring gene STARR-seq mESC enhancer starr_01318 Neighboring gene microRNA 6351 Neighboring gene STARR-seq mESC enhancer starr_01319 Neighboring gene STARR-seq mESC enhancer starr_01321 Neighboring gene predicted gene, 39664 Neighboring gene STARR-positive B cell enhancer ABC_E11074 Neighboring gene VISTA enhancer mm1630 Neighboring gene predicted gene, 31637 Neighboring gene RUN and FYVE domain containing 4 Neighboring gene C-X-C motif chemokine receptor 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (4) 
    • Targeted (2)  1 citation

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables actin binding TAS
    Traceable Author Statement
    more info
    PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables phosphoprotein phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of_or_within cell-substrate junction assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in fibroblast migration IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within fibroblast migration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in cell surface IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cell-substrate junction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in focal adhesion IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in focal adhesion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in focal adhesion ISO
    Inferred from Sequence Orthology
    more info
    PubMed 

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001289895.2NP_001276824.1  tensin-1 isoform b

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks two in-frame exons in the 3' coding region, compared to variant 1, resulting in an isoform (b) that is shorter than isoform a.
      Source sequence(s)
      AC116419, AC117757
      Consensus CDS
      CCDS48288.2
      UniProtKB/TrEMBL
      A0A087WQS0, A0A1D5RM59
      Related
      ENSMUSP00000140317.2, ENSMUST00000191104.7
      Conserved Domains (5) summary
      cd09927
      Location:15911706
      SH2_Tensin_like; Src homology 2 domain found in Tensin-like proteins
      smart00404
      Location:248363
      PTPc_motif; Protein tyrosine phosphatase, catalytic domain motif
      cd01213
      Location:17281861
      PTB_tensin; Tensin Phosphotyrosine-binding (PTB) domain
      pfam10409
      Location:350476
      PTEN_C2; C2 domain of PTEN tumour-suppressor protein
      cl00040
      Location:75108
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    2. NM_001413787.1NP_001400716.1  tensin-1 isoform c

      Status: VALIDATED

      Source sequence(s)
      AC116419, AC117757
      Related
      ENSMUSP00000140254.2, ENSMUST00000187584.7
    3. NM_001413788.1NP_001400717.1  tensin-1 isoform d

      Status: VALIDATED

      Source sequence(s)
      AC116419
    4. NM_001413789.1NP_001400718.1  tensin-1 isoform d

      Status: VALIDATED

      Source sequence(s)
      AC116419, AC117757
    5. NM_001413790.1NP_001400719.1  tensin-1 isoform e

      Status: VALIDATED

      Source sequence(s)
      AC116419, AC117757
      Related
      ENSMUSP00000140771.2, ENSMUST00000185331.7
    6. NM_001413791.1NP_001400720.1  tensin-1 isoform f

      Status: VALIDATED

      Source sequence(s)
      AC116419, AC117757
    7. NM_027884.4NP_082160.3  tensin-1 isoform a

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).
      Source sequence(s)
      AC116419, AC117757
      Consensus CDS
      CCDS78614.1
      UniProtKB/Swiss-Prot
      E9Q0S6
      UniProtKB/TrEMBL
      A0A1D5RM59
      Related
      ENSMUSP00000127715.2, ENSMUST00000169786.8
      Conserved Domains (5) summary
      cd09927
      Location:16121727
      SH2_Tensin_like; Src homology 2 domain found in Tensin-like proteins
      smart00404
      Location:248363
      PTPc_motif; Protein tyrosine phosphatase, catalytic domain motif
      cd01213
      Location:17491882
      PTB_tensin; Tensin Phosphotyrosine-binding (PTB) domain
      pfam10409
      Location:350476
      PTEN_C2; C2 domain of PTEN tumour-suppressor protein
      cl00040
      Location:75108
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      73949391..74163707 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030252982.1XP_030108842.1  tensin-1 isoform X8

      UniProtKB/TrEMBL
      A0A1D5RM59
      Conserved Domains (6) summary
      cd09927
      Location:16401755
      SH2_Tensin_like; Src homology 2 domain found in Tensin-like proteins
      PHA03247
      Location:10671643
      PHA03247; large tegument protein UL36; Provisional
      cd01213
      Location:17771910
      PTB_tensin; Tensin Phosphotyrosine-binding (PTB) domain
      pfam10409
      Location:350476
      PTEN_C2; C2 domain of PTEN tumor-suppressor protein
      cl00040
      Location:75108
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cl28904
      Location:185343
      PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily
    2. XM_006495871.4XP_006495934.1  tensin-1 isoform X7

      UniProtKB/TrEMBL
      A0A1D5RM59
      Conserved Domains (6) summary
      cd09927
      Location:16421757
      SH2_Tensin_like; Src homology 2 domain found in Tensin-like proteins
      PHA03247
      Location:10691645
      PHA03247; large tegument protein UL36; Provisional
      cd01213
      Location:17791912
      PTB_tensin; Tensin Phosphotyrosine-binding (PTB) domain
      pfam10409
      Location:350476
      PTEN_C2; C2 domain of PTEN tumor-suppressor protein
      cl00040
      Location:75108
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cl28904
      Location:185343
      PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily
    3. XM_017319864.1XP_017175353.1  tensin-1 isoform X15

      UniProtKB/TrEMBL
      A0A087WQM0
      Conserved Domains (7) summary
      cd09927
      Location:15951710
      SH2_Tensin_like; Src homology 2 domain found in Tensin-like proteins
      PHA03247
      Location:9121598
      PHA03247; large tegument protein UL36; Provisional
      PHA03307
      Location:6891081
      PHA03307; transcriptional regulator ICP4; Provisional
      cd01213
      Location:17321865
      PTB_tensin; Tensin Phosphotyrosine-binding (PTB) domain
      pfam10409
      Location:354480
      PTEN_C2; C2 domain of PTEN tumor-suppressor protein
      cl00040
      Location:79112
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cl28904
      Location:189347
      PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily
    4. XM_017319860.1XP_017175349.1  tensin-1 isoform X12

      UniProtKB/TrEMBL
      A0A087WQM0
      Conserved Domains (7) summary
      cd09927
      Location:16031718
      SH2_Tensin_like; Src homology 2 domain found in Tensin-like proteins
      PHA03247
      Location:9121606
      PHA03247; large tegument protein UL36; Provisional
      PHA03307
      Location:6891081
      PHA03307; transcriptional regulator ICP4; Provisional
      cd01213
      Location:17401873
      PTB_tensin; Tensin Phosphotyrosine-binding (PTB) domain
      pfam10409
      Location:354480
      PTEN_C2; C2 domain of PTEN tumor-suppressor protein
      cl00040
      Location:79112
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cl28904
      Location:189347
      PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily
    5. XM_017319859.1XP_017175348.1  tensin-1 isoform X10

      UniProtKB/TrEMBL
      A0A087WQM0
      Conserved Domains (6) summary
      cd09927
      Location:16161731
      SH2_Tensin_like; Src homology 2 domain found in Tensin-like proteins
      PHA03247
      Location:10431619
      PHA03247; large tegument protein UL36; Provisional
      cd01213
      Location:17531886
      PTB_tensin; Tensin Phosphotyrosine-binding (PTB) domain
      pfam10409
      Location:354480
      PTEN_C2; C2 domain of PTEN tumor-suppressor protein
      cl00040
      Location:79112
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cl28904
      Location:189347
      PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily
    6. XM_036163578.1XP_036019471.1  tensin-1 isoform X4

      UniProtKB/TrEMBL
      A0A087WQM0
      Conserved Domains (6) summary
      cd09927
      Location:16361751
      SH2_Tensin_like; Src homology 2 domain found in Tensin-like proteins
      PHA03247
      Location:9641482
      PHA03247; large tegument protein UL36; Provisional
      cd01213
      Location:17731906
      PTB_tensin; Tensin Phosphotyrosine-binding (PTB) domain
      pfam10409
      Location:354480
      PTEN_C2; C2 domain of PTEN tumor-suppressor protein
      cl00040
      Location:61116
      C1; protein kinase C conserved region 1 (C1 domain) superfamily
      cl28904
      Location:189347
      PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily
    7. XM_017319847.1XP_017175336.1  tensin-1 isoform X2

      UniProtKB/TrEMBL
      A0A087WQM0
      Conserved Domains (6) summary
      cd09927
      Location:16441759
      SH2_Tensin_like; Src homology 2 domain found in Tensin-like proteins
      PHA03247
      Location:10711647
      PHA03247; large tegument protein UL36; Provisional
      cd01213
      Location:17811914
      PTB_tensin; Tensin Phosphotyrosine-binding (PTB) domain
      pfam10409
      Location:354480
      PTEN_C2; C2 domain of PTEN tumor-suppressor protein
      cl00040
      Location:79112
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cl28904
      Location:189347
      PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily
    8. XM_017319866.1XP_017175355.1  tensin-1 isoform X23

      UniProtKB/TrEMBL
      A0A087WQM0
      Conserved Domains (7) summary
      cd09927
      Location:14751590
      SH2_Tensin_like; Src homology 2 domain found in Tensin-like proteins
      PHA03247
      Location:9071478
      PHA03247; large tegument protein UL36; Provisional
      cd01213
      Location:16121745
      PTB_tensin; Tensin Phosphotyrosine-binding (PTB) domain
      pfam03154
      Location:5801028
      Atrophin-1; Atrophin-1 family
      pfam10409
      Location:354480
      PTEN_C2; C2 domain of PTEN tumor-suppressor protein
      cl00040
      Location:79112
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cl28904
      Location:189347
      PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily
    9. XM_030252984.1XP_030108844.1  tensin-1 isoform X22

      UniProtKB/TrEMBL
      A0A087WQM0
      Conserved Domains (7) summary
      cd09927
      Location:15061621
      SH2_Tensin_like; Src homology 2 domain found in Tensin-like proteins
      PHA03247
      Location:9461509
      PHA03247; large tegument protein UL36; Provisional
      cd01213
      Location:16431776
      PTB_tensin; Tensin Phosphotyrosine-binding (PTB) domain
      pfam03154
      Location:5801028
      Atrophin-1; Atrophin-1 family
      pfam10409
      Location:354480
      PTEN_C2; C2 domain of PTEN tumor-suppressor protein
      cl00040
      Location:79112
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cl28904
      Location:189347
      PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily
    10. XM_017319865.1XP_017175354.1  tensin-1 isoform X21

      UniProtKB/TrEMBL
      A0A087WQM0
      Conserved Domains (6) summary
      cd09927
      Location:15271642
      SH2_Tensin_like; Src homology 2 domain found in Tensin-like proteins
      PHA03247
      Location:9761530
      PHA03247; large tegument protein UL36; Provisional
      cd01213
      Location:16641797
      PTB_tensin; Tensin Phosphotyrosine-binding (PTB) domain
      pfam10409
      Location:354480
      PTEN_C2; C2 domain of PTEN tumor-suppressor protein
      cl00040
      Location:79112
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cl28904
      Location:189347
      PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily
    11. XM_017319863.1XP_017175352.1  tensin-1 isoform X14

      UniProtKB/TrEMBL
      A0A087WQM0
      Conserved Domains (7) summary
      cd09927
      Location:15971712
      SH2_Tensin_like; Src homology 2 domain found in Tensin-like proteins
      PHA03247
      Location:9141600
      PHA03247; large tegument protein UL36; Provisional
      PHA03307
      Location:6911083
      PHA03307; transcriptional regulator ICP4; Provisional
      cd01213
      Location:17341867
      PTB_tensin; Tensin Phosphotyrosine-binding (PTB) domain
      pfam10409
      Location:354480
      PTEN_C2; C2 domain of PTEN tumor-suppressor protein
      cl00040
      Location:79112
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cl28904
      Location:189347
      PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily
    12. XM_036163588.1XP_036019481.1  tensin-1 isoform X11

      UniProtKB/TrEMBL
      A0A087WQM0
      Conserved Domains (6) summary
      cd09927
      Location:16101725
      SH2_Tensin_like; Src homology 2 domain found in Tensin-like proteins
      PHA03247
      Location:10451613
      PHA03247; large tegument protein UL36; Provisional
      cd01213
      Location:17471880
      PTB_tensin; Tensin Phosphotyrosine-binding (PTB) domain
      pfam10409
      Location:354480
      PTEN_C2; C2 domain of PTEN tumor-suppressor protein
      cl00040
      Location:61116
      C1; protein kinase C conserved region 1 (C1 domain) superfamily
      cl28904
      Location:189347
      PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily
    13. XM_017319858.1XP_017175347.1  tensin-1 isoform X9

      UniProtKB/TrEMBL
      A0A087WQM0
      Conserved Domains (6) summary
      cd09927
      Location:16181733
      SH2_Tensin_like; Src homology 2 domain found in Tensin-like proteins
      PHA03247
      Location:10451621
      PHA03247; large tegument protein UL36; Provisional
      cd01213
      Location:17551888
      PTB_tensin; Tensin Phosphotyrosine-binding (PTB) domain
      pfam10409
      Location:354480
      PTEN_C2; C2 domain of PTEN tumor-suppressor protein
      cl00040
      Location:79112
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cl28904
      Location:189347
      PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily
    14. XM_017319856.1XP_017175345.1  tensin-1 isoform X6

      UniProtKB/TrEMBL
      A0A087WQM0
      Conserved Domains (6) summary
      cd09927
      Location:16251740
      SH2_Tensin_like; Src homology 2 domain found in Tensin-like proteins
      PHA03247
      Location:9661471
      PHA03247; large tegument protein UL36; Provisional
      cd01213
      Location:17621895
      PTB_tensin; Tensin Phosphotyrosine-binding (PTB) domain
      pfam10409
      Location:354480
      PTEN_C2; C2 domain of PTEN tumor-suppressor protein
      cl00040
      Location:79112
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cl28904
      Location:189347
      PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily
    15. XM_017319848.1XP_017175337.1  tensin-1 isoform X3

      UniProtKB/TrEMBL
      A0A087WQM0
      Conserved Domains (6) summary
      cd09927
      Location:16381753
      SH2_Tensin_like; Src homology 2 domain found in Tensin-like proteins
      PHA03247
      Location:9661484
      PHA03247; large tegument protein UL36; Provisional
      cd01213
      Location:17751908
      PTB_tensin; Tensin Phosphotyrosine-binding (PTB) domain
      pfam10409
      Location:354480
      PTEN_C2; C2 domain of PTEN tumor-suppressor protein
      cl00040
      Location:79112
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cl28904
      Location:189347
      PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily
    16. XM_017319853.1XP_017175342.1  tensin-1 isoform X5

      UniProtKB/TrEMBL
      A0A087WQM0
      Conserved Domains (6) summary
      cd09927
      Location:16331748
      SH2_Tensin_like; Src homology 2 domain found in Tensin-like proteins
      PHA03247
      Location:9661479
      PHA03247; large tegument protein UL36; Provisional
      cd01213
      Location:17701903
      PTB_tensin; Tensin Phosphotyrosine-binding (PTB) domain
      pfam10409
      Location:354480
      PTEN_C2; C2 domain of PTEN tumor-suppressor protein
      cl00040
      Location:79112
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cl28904
      Location:189347
      PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily
    17. XM_006495867.2XP_006495930.2  tensin-1 isoform X1

      UniProtKB/TrEMBL
      A0A087WQM0
      Conserved Domains (6) summary
      cd09927
      Location:16461761
      SH2_Tensin_like; Src homology 2 domain found in Tensin-like proteins
      PHA03247
      Location:10731649
      PHA03247; large tegument protein UL36; Provisional
      cd01213
      Location:17831916
      PTB_tensin; Tensin Phosphotyrosine-binding (PTB) domain
      pfam10409
      Location:354480
      PTEN_C2; C2 domain of PTEN tumor-suppressor protein
      cl00040
      Location:79112
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cl28904
      Location:189347
      PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily
    18. XM_006495878.4XP_006495941.1  tensin-1 isoform X24

      See identical proteins and their annotated locations for XP_006495941.1

      UniProtKB/TrEMBL
      A0A087WQ94
      Conserved Domains (5) summary
      cd09927
      Location:14921607
      SH2_Tensin_like; Src homology 2 domain found in Tensin-like proteins
      PHA03247
      Location:9191495
      PHA03247; large tegument protein UL36; Provisional
      cd01213
      Location:16291762
      PTB_tensin; Tensin Phosphotyrosine-binding (PTB) domain
      pfam10409
      Location:200326
      PTEN_C2; C2 domain of PTEN tumor-suppressor protein
      cl28904
      Location:35193
      PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily
    19. XM_017319862.3XP_017175351.1  tensin-1 isoform X13

      UniProtKB/TrEMBL
      A0A6I8MWZ2
      Conserved Domains (6) summary
      cd09927
      Location:16221737
      SH2_Tensin_like; Src homology 2 domain found in Tensin-like proteins
      PHA03247
      Location:10491625
      PHA03247; large tegument protein UL36; Provisional
      cd01213
      Location:17591892
      PTB_tensin; Tensin Phosphotyrosine-binding (PTB) domain
      pfam10409
      Location:330456
      PTEN_C2; C2 domain of PTEN tumor-suppressor protein
      cl00040
      Location:5588
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cl28904
      Location:165323
      PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily
    20. XM_030252983.1XP_030108843.1  tensin-1 isoform X17

      UniProtKB/TrEMBL
      A0A087WQM0
      Conserved Domains (6) summary
      cd09927
      Location:15991714
      SH2_Tensin_like; Src homology 2 domain found in Tensin-like proteins
      PHA03247
      Location:10261602
      PHA03247; large tegument protein UL36; Provisional
      cd01213
      Location:17361869
      PTB_tensin; Tensin Phosphotyrosine-binding (PTB) domain
      pfam10409
      Location:309435
      PTEN_C2; C2 domain of PTEN tumor-suppressor protein
      cl00040
      Location:3467
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cl28904
      Location:144302
      PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily
    21. XM_006495872.1XP_006495935.1  tensin-1 isoform X16

      UniProtKB/TrEMBL
      A0A087WQM0
      Conserved Domains (6) summary
      cd09927
      Location:16011716
      SH2_Tensin_like; Src homology 2 domain found in Tensin-like proteins
      PHA03247
      Location:10281604
      PHA03247; large tegument protein UL36; Provisional
      cd01213
      Location:17381871
      PTB_tensin; Tensin Phosphotyrosine-binding (PTB) domain
      pfam10409
      Location:309435
      PTEN_C2; C2 domain of PTEN tumor-suppressor protein
      cl00040
      Location:3467
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cl28904
      Location:144302
      PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily
    22. XM_006495875.2XP_006495938.1  tensin-1 isoform X20

      UniProtKB/TrEMBL
      A0A087WQM0
      Conserved Domains (5) summary
      cd09927
      Location:15531668
      SH2_Tensin_like; Src homology 2 domain found in Tensin-like proteins
      PHA03247
      Location:9801556
      PHA03247; large tegument protein UL36; Provisional
      cd01213
      Location:16901823
      PTB_tensin; Tensin Phosphotyrosine-binding (PTB) domain
      pfam10409
      Location:261387
      PTEN_C2; C2 domain of PTEN tumor-suppressor protein
      cl28904
      Location:96254
      PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily
    23. XM_036163612.1XP_036019505.1  tensin-1 isoform X26

      UniProtKB/TrEMBL
      A0A087WQ94
      Conserved Domains (5) summary
      cd09927
      Location:14821597
      SH2_Tensin_like; Src homology 2 domain found in Tensin-like proteins
      PHA03247
      Location:8101328
      PHA03247; large tegument protein UL36; Provisional
      cd01213
      Location:16191752
      PTB_tensin; Tensin Phosphotyrosine-binding (PTB) domain
      pfam10409
      Location:200326
      PTEN_C2; C2 domain of PTEN tumor-suppressor protein
      cl28904
      Location:35193
      PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily
    24. XM_011238476.3XP_011236778.1  tensin-1 isoform X24

      See identical proteins and their annotated locations for XP_011236778.1

      UniProtKB/TrEMBL
      A0A087WQ94
      Conserved Domains (5) summary
      cd09927
      Location:14921607
      SH2_Tensin_like; Src homology 2 domain found in Tensin-like proteins
      PHA03247
      Location:9191495
      PHA03247; large tegument protein UL36; Provisional
      cd01213
      Location:16291762
      PTB_tensin; Tensin Phosphotyrosine-binding (PTB) domain
      pfam10409
      Location:200326
      PTEN_C2; C2 domain of PTEN tumor-suppressor protein
      cl28904
      Location:35193
      PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily
    25. XM_006495874.4XP_006495937.1  tensin-1 isoform X19

      UniProtKB/TrEMBL
      A0A087WQ94
      Conserved Domains (5) summary
      cd09927
      Location:15681683
      SH2_Tensin_like; Src homology 2 domain found in Tensin-like proteins
      PHA03247
      Location:9951571
      PHA03247; large tegument protein UL36; Provisional
      cd01213
      Location:17051838
      PTB_tensin; Tensin Phosphotyrosine-binding (PTB) domain
      pfam10409
      Location:276402
      PTEN_C2; C2 domain of PTEN tumor-suppressor protein
      cl28904
      Location:111269
      PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily
    26. XM_030252985.2XP_030108845.1  tensin-1 isoform X25

      UniProtKB/TrEMBL
      A0A087WQ94
      Conserved Domains (5) summary
      cd09927
      Location:14901605
      SH2_Tensin_like; Src homology 2 domain found in Tensin-like proteins
      PHA03247
      Location:9171493
      PHA03247; large tegument protein UL36; Provisional
      cd01213
      Location:16271760
      PTB_tensin; Tensin Phosphotyrosine-binding (PTB) domain
      pfam10409
      Location:200326
      PTEN_C2; C2 domain of PTEN tumor-suppressor protein
      cl28904
      Location:35193
      PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily
    27. XM_006495877.4XP_006495940.1  tensin-1 isoform X24

      See identical proteins and their annotated locations for XP_006495940.1

      UniProtKB/TrEMBL
      A0A087WQ94
      Conserved Domains (5) summary
      cd09927
      Location:14921607
      SH2_Tensin_like; Src homology 2 domain found in Tensin-like proteins
      PHA03247
      Location:9191495
      PHA03247; large tegument protein UL36; Provisional
      cd01213
      Location:16291762
      PTB_tensin; Tensin Phosphotyrosine-binding (PTB) domain
      pfam10409
      Location:200326
      PTEN_C2; C2 domain of PTEN tumor-suppressor protein
      cl28904
      Location:35193
      PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily
    28. XM_006495880.4XP_006495943.1  tensin-1 isoform X24

      See identical proteins and their annotated locations for XP_006495943.1

      UniProtKB/TrEMBL
      A0A087WQ94
      Conserved Domains (5) summary
      cd09927
      Location:14921607
      SH2_Tensin_like; Src homology 2 domain found in Tensin-like proteins
      PHA03247
      Location:9191495
      PHA03247; large tegument protein UL36; Provisional
      cd01213
      Location:16291762
      PTB_tensin; Tensin Phosphotyrosine-binding (PTB) domain
      pfam10409
      Location:200326
      PTEN_C2; C2 domain of PTEN tumor-suppressor protein
      cl28904
      Location:35193
      PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily
    29. XM_006495873.2XP_006495936.2  tensin-1 isoform X18

      UniProtKB/TrEMBL
      A0A087WQ94
      Conserved Domains (5) summary
      cd09927
      Location:15521667
      SH2_Tensin_like; Src homology 2 domain found in Tensin-like proteins
      PHA03247
      Location:9791555
      PHA03247; large tegument protein UL36; Provisional
      cd01213
      Location:16891822
      PTB_tensin; Tensin Phosphotyrosine-binding (PTB) domain
      pfam10409
      Location:260386
      PTEN_C2; C2 domain of PTEN tumor-suppressor protein
      cl28904
      Location:95253
      PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily
    30. XM_011238477.2XP_011236779.1  tensin-1 isoform X24

      See identical proteins and their annotated locations for XP_011236779.1

      UniProtKB/TrEMBL
      A0A087WQ94
      Conserved Domains (5) summary
      cd09927
      Location:14921607
      SH2_Tensin_like; Src homology 2 domain found in Tensin-like proteins
      PHA03247
      Location:9191495
      PHA03247; large tegument protein UL36; Provisional
      cd01213
      Location:16291762
      PTB_tensin; Tensin Phosphotyrosine-binding (PTB) domain
      pfam10409
      Location:200326
      PTEN_C2; C2 domain of PTEN tumor-suppressor protein
      cl28904
      Location:35193
      PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily
    31. XM_006495879.1XP_006495942.1  tensin-1 isoform X24

      See identical proteins and their annotated locations for XP_006495942.1

      UniProtKB/TrEMBL
      A0A087WQ94
      Conserved Domains (5) summary
      cd09927
      Location:14921607
      SH2_Tensin_like; Src homology 2 domain found in Tensin-like proteins
      PHA03247
      Location:9191495
      PHA03247; large tegument protein UL36; Provisional
      cd01213
      Location:16291762
      PTB_tensin; Tensin Phosphotyrosine-binding (PTB) domain
      pfam10409
      Location:200326
      PTEN_C2; C2 domain of PTEN tumor-suppressor protein
      cl28904
      Location:35193
      PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily
    32. XM_036163609.1XP_036019502.1  tensin-1 isoform X24

      UniProtKB/TrEMBL
      A0A087WQ94
      Conserved Domains (5) summary
      cd09927
      Location:14921607
      SH2_Tensin_like; Src homology 2 domain found in Tensin-like proteins
      PHA03247
      Location:9191495
      PHA03247; large tegument protein UL36; Provisional
      cd01213
      Location:16291762
      PTB_tensin; Tensin Phosphotyrosine-binding (PTB) domain
      pfam10409
      Location:200326
      PTEN_C2; C2 domain of PTEN tumor-suppressor protein
      cl28904
      Location:35193
      PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily
    33. XM_006495881.4XP_006495944.1  tensin-1 isoform X24

      See identical proteins and their annotated locations for XP_006495944.1

      UniProtKB/TrEMBL
      A0A087WQ94
      Conserved Domains (5) summary
      cd09927
      Location:14921607
      SH2_Tensin_like; Src homology 2 domain found in Tensin-like proteins
      PHA03247
      Location:9191495
      PHA03247; large tegument protein UL36; Provisional
      cd01213
      Location:16291762
      PTB_tensin; Tensin Phosphotyrosine-binding (PTB) domain
      pfam10409
      Location:200326
      PTEN_C2; C2 domain of PTEN tumor-suppressor protein
      cl28904
      Location:35193
      PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily
    34. XM_006495882.4XP_006495945.1  tensin-1 isoform X24

      See identical proteins and their annotated locations for XP_006495945.1

      UniProtKB/TrEMBL
      A0A087WQ94
      Related
      ENSMUSP00000140094.2, ENSMUST00000185702.7
      Conserved Domains (5) summary
      cd09927
      Location:14921607
      SH2_Tensin_like; Src homology 2 domain found in Tensin-like proteins
      PHA03247
      Location:9191495
      PHA03247; large tegument protein UL36; Provisional
      cd01213
      Location:16291762
      PTB_tensin; Tensin Phosphotyrosine-binding (PTB) domain
      pfam10409
      Location:200326
      PTEN_C2; C2 domain of PTEN tumor-suppressor protein
      cl28904
      Location:35193
      PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily
    35. XM_030252988.1XP_030108848.1  tensin-1 isoform X33

      Conserved Domains (3) summary
      cd09927
      Location:842957
      SH2_Tensin_like; Src homology 2 domain found in Tensin-like proteins
      PHA03247
      Location:274845
      PHA03247; large tegument protein UL36; Provisional
      cd01213
      Location:9791112
      PTB_tensin; Tensin Phosphotyrosine-binding (PTB) domain
    36. XM_036163624.1XP_036019517.1  tensin-1 isoform X32

      Conserved Domains (3) summary
      cd09927
      Location:8861001
      SH2_Tensin_like; Src homology 2 domain found in Tensin-like proteins
      PHA03247
      Location:343889
      PHA03247; large tegument protein UL36; Provisional
      cd01213
      Location:10231156
      PTB_tensin; Tensin Phosphotyrosine-binding (PTB) domain
    37. XM_030252987.1XP_030108847.1  tensin-1 isoform X31

      Conserved Domains (3) summary
      cd09927
      Location:9641079
      SH2_Tensin_like; Src homology 2 domain found in Tensin-like proteins
      PHA03247
      Location:282931
      PHA03247; large tegument protein UL36; Provisional
      cd01213
      Location:11011234
      PTB_tensin; Tensin Phosphotyrosine-binding (PTB) domain
    38. XM_036163621.1XP_036019514.1  tensin-1 isoform X30

      Conserved Domains (3) summary
      cd09927
      Location:9771092
      SH2_Tensin_like; Src homology 2 domain found in Tensin-like proteins
      PHA03247
      Location:412944
      PHA03247; large tegument protein UL36; Provisional
      cd01213
      Location:11141247
      PTB_tensin; Tensin Phosphotyrosine-binding (PTB) domain
    39. XM_030252986.1XP_030108846.1  tensin-1 isoform X29

      Conserved Domains (3) summary
      cd09927
      Location:9851100
      SH2_Tensin_like; Src homology 2 domain found in Tensin-like proteins
      PHA03247
      Location:412952
      PHA03247; large tegument protein UL36; Provisional
      cd01213
      Location:11221255
      PTB_tensin; Tensin Phosphotyrosine-binding (PTB) domain
    40. XM_036163620.1XP_036019513.1  tensin-1 isoform X28

      Conserved Domains (3) summary
      cd09927
      Location:10051120
      SH2_Tensin_like; Src homology 2 domain found in Tensin-like proteins
      PHA03247
      Location:333851
      PHA03247; large tegument protein UL36; Provisional
      cd01213
      Location:11421275
      PTB_tensin; Tensin Phosphotyrosine-binding (PTB) domain
    41. XM_006495883.2XP_006495946.1  tensin-1 isoform X27

      Conserved Domains (3) summary
      cd09927
      Location:10131128
      SH2_Tensin_like; Src homology 2 domain found in Tensin-like proteins
      PHA03247
      Location:440980
      PHA03247; large tegument protein UL36; Provisional
      cd01213
      Location:11501283
      PTB_tensin; Tensin Phosphotyrosine-binding (PTB) domain

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_177169.2: Suppressed sequence

      Description
      NM_177169.2: This RefSeq was permanently suppressed because it contains the wrong CDS.