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    Zfp217 zinc finger protein 217 [ Mus musculus (house mouse) ]

    Gene ID: 228913, updated on 9-Dec-2024

    Summary

    Official Symbol
    Zfp217provided by MGI
    Official Full Name
    zinc finger protein 217provided by MGI
    Primary source
    MGI:MGI:2685408
    See related
    Ensembl:ENSMUSG00000052056 AllianceGenome:MGI:2685408
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gm562; ZABC1; Znf217; 4933431C08Rik
    Summary
    Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II. Predicted to act upstream of or within cellular senescence. Predicted to be located in mitochondrion and nuclear speck. Predicted to be part of histone deacetylase complex. Predicted to be active in nucleus. Is expressed in central nervous system; genitourinary system; paraxial mesenchyme; and tail. Orthologous to human ZNF217 (zinc finger protein 217). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in testis adult (RPKM 23.1), thymus adult (RPKM 7.0) and 23 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Zfp217 in Genome Data Viewer
    Location:
    2 H3; 2 89.91 cM
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (169950563..169993598, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (170108643..170151677, complement)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene teashirt zinc finger family member 2 Neighboring gene STARR-seq mESC enhancer starr_06500 Neighboring gene cDNA sequence AY702102 Neighboring gene STARR-seq mESC enhancer starr_06501 Neighboring gene STARR-seq mESC enhancer starr_06502 Neighboring gene STARR-seq mESC enhancer starr_06503 Neighboring gene RIKEN cDNA A630075F10 gene Neighboring gene STARR-positive B cell enhancer ABC_E6026 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:169978978-169979087 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:169980510-169980753 Neighboring gene STARR-positive B cell enhancer ABC_E9210 Neighboring gene STARR-positive B cell enhancer ABC_E10165 Neighboring gene STARR-positive B cell enhancer ABC_E2658 Neighboring gene STARR-seq mESC enhancer starr_06515 Neighboring gene predicted gene, 34403 Neighboring gene predicted gene, 17619

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Component Evidence Code Pubs
    part_of histone deacetylase complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nuclear speck ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001033299.4NP_001028471.1  zinc finger protein 217

      See identical proteins and their annotated locations for NP_001028471.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript.
      Source sequence(s)
      AL844576
      Consensus CDS
      CCDS17120.1
      UniProtKB/TrEMBL
      Q3U0X6
      Related
      ENSMUSP00000067334.7, ENSMUST00000063710.13
      Conserved Domains (5) summary
      sd00017
      Location:123143
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:480500
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:479500
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:492517
      zf-H2C2_2; Zinc-finger double domain
      pfam13909
      Location:506530
      zf-H2C2_5; C2H2-type zinc-finger domain
    2. NM_001159683.1NP_001153155.1  zinc finger protein 217

      See identical proteins and their annotated locations for NP_001153155.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. All three variants encode the same protein.
      Source sequence(s)
      AK139547, AL844576, BC116330
      Consensus CDS
      CCDS17120.1
      UniProtKB/TrEMBL
      Q3U0X6
      Related
      ENSMUSP00000104783.2, ENSMUST00000109155.8
      Conserved Domains (5) summary
      sd00017
      Location:123143
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:480500
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:479500
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:492517
      zf-H2C2_2; Zinc-finger double domain
      pfam13909
      Location:506530
      zf-H2C2_5; C2H2-type zinc-finger domain
    3. NM_001434160.1NP_001421089.1  zinc finger protein 217

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. All three variants encode the same protein.
      Source sequence(s)
      AL844576
      UniProtKB/TrEMBL
      Q3U0X6

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      169950563..169993598 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006499428.4XP_006499491.1  zinc finger protein 217 isoform X1

      See identical proteins and their annotated locations for XP_006499491.1

      UniProtKB/TrEMBL
      Q3U0X6
      Conserved Domains (5) summary
      sd00017
      Location:123143
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:480500
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:479500
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:492517
      zf-H2C2_2; Zinc-finger double domain
      pfam13909
      Location:506530
      zf-H2C2_5; C2H2-type zinc-finger domain
    2. XM_006499430.3XP_006499493.1  zinc finger protein 217 isoform X1

      See identical proteins and their annotated locations for XP_006499493.1

      UniProtKB/TrEMBL
      Q3U0X6
      Conserved Domains (5) summary
      sd00017
      Location:123143
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:480500
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:479500
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:492517
      zf-H2C2_2; Zinc-finger double domain
      pfam13909
      Location:506530
      zf-H2C2_5; C2H2-type zinc-finger domain
    3. XM_006499434.4XP_006499497.1  zinc finger protein 217 isoform X2

      Conserved Domains (5) summary
      sd00017
      Location:123143
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:480500
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:479500
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:492517
      zf-H2C2_2; Zinc-finger double domain
      pfam13909
      Location:506530
      zf-H2C2_5; C2H2-type zinc-finger domain
    4. XM_006499427.4XP_006499490.1  zinc finger protein 217 isoform X1

      See identical proteins and their annotated locations for XP_006499490.1

      UniProtKB/TrEMBL
      Q3U0X6
      Conserved Domains (5) summary
      sd00017
      Location:123143
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:480500
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:479500
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:492517
      zf-H2C2_2; Zinc-finger double domain
      pfam13909
      Location:506530
      zf-H2C2_5; C2H2-type zinc-finger domain
    5. XM_006499429.5XP_006499492.1  zinc finger protein 217 isoform X1

      See identical proteins and their annotated locations for XP_006499492.1

      UniProtKB/TrEMBL
      Q3U0X6
      Conserved Domains (5) summary
      sd00017
      Location:123143
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:480500
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:479500
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:492517
      zf-H2C2_2; Zinc-finger double domain
      pfam13909
      Location:506530
      zf-H2C2_5; C2H2-type zinc-finger domain
    6. XM_030250755.1XP_030106615.1  zinc finger protein 217 isoform X1

      UniProtKB/TrEMBL
      Q3U0X6
      Conserved Domains (5) summary
      sd00017
      Location:123143
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:480500
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:479500
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:492517
      zf-H2C2_2; Zinc-finger double domain
      pfam13909
      Location:506530
      zf-H2C2_5; C2H2-type zinc-finger domain
    7. XM_036161709.1XP_036017602.1  zinc finger protein 217 isoform X1

      UniProtKB/TrEMBL
      Q3U0X6
      Conserved Domains (5) summary
      sd00017
      Location:123143
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:480500
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:479500
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:492517
      zf-H2C2_2; Zinc-finger double domain
      pfam13909
      Location:506530
      zf-H2C2_5; C2H2-type zinc-finger domain
    8. XM_006499431.4XP_006499494.1  zinc finger protein 217 isoform X1

      Conserved Domains (5) summary
      sd00017
      Location:123143
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:480500
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:479500
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:492517
      zf-H2C2_2; Zinc-finger double domain
      pfam13909
      Location:506530
      zf-H2C2_5; C2H2-type zinc-finger domain
    9. XM_006499432.5XP_006499495.1  zinc finger protein 217 isoform X1

      See identical proteins and their annotated locations for XP_006499495.1

      UniProtKB/TrEMBL
      Q3U0X6
      Conserved Domains (5) summary
      sd00017
      Location:123143
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:480500
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:479500
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:492517
      zf-H2C2_2; Zinc-finger double domain
      pfam13909
      Location:506530
      zf-H2C2_5; C2H2-type zinc-finger domain
    10. XM_006499433.4XP_006499496.1  zinc finger protein 217 isoform X1

      See identical proteins and their annotated locations for XP_006499496.1

      UniProtKB/TrEMBL
      Q3U0X6
      Conserved Domains (5) summary
      sd00017
      Location:123143
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:480500
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:479500
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:492517
      zf-H2C2_2; Zinc-finger double domain
      pfam13909
      Location:506530
      zf-H2C2_5; C2H2-type zinc-finger domain