Dclk2 doublecortin-like kinase 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Dclk2provided by MGI
Official Full Name: doublecortin-like kinase 2provided by MGI
Primary source: MGI:MGI:1918012
See related: Ensembl:ENSMUSG00000028078 AllianceGenome:MGI:1918012
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: CL2; CLICK2; Dcamkl2; Click-II; 6330415M09Rik
Summary: This gene encodes a member of the protein kinase superfamily and the doublecortin family. The protein encoded by this gene contains two N-terminal doublecortin domains, which bind microtubules and regulate microtubule polymerization, a C-terminal serine/threonine protein kinase domain, which shows substantial homology to Ca2+/calmoduline-dependent protein kinase, and a serine/proline-rich domain in between the doublecortin and the protein kinase domains, which mediates multiple protein-protein interactions. The microtubule-polymerizing activity of the encoded protein is independent of its protein kinase activity. This gene and the DCX gene, another family member, share function in the establishment of hippocampal organization and their absence results in a severe epileptic phenotype and lethality, as described in human patients with lissencephaly. Multiple alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Sep 2010]
Expression: Biased expression in whole brain E14.5 (RPKM 41.0), CNS E14 (RPKM 37.3) and 11 other tissues See more
Orthologs: human all
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Genomic context

Location:: 3 F1; 3 37.88 cM

Exon count:: 18

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	3	NC_000069.7 (86693457..86828292, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	3	NC_000069.6 (86786150..86920952, complement)

Chromosome 3 - NC_000069.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Cpeb4-mediated Dclk2 promotes neuronal pyroptosis induced by chronic cerebral ischemia through phosphorylation of Ehf.
Title: Cpeb4-mediated Dclk2 promotes neuronal pyroptosis induced by chronic cerebral ischemia through phosphorylation of Ehf.
Dclk2 promotes axonal regeneration, neuronal survival, and growth core reformation via microtubule stabilization, prevention of F-actin destabilization and synergy with mTOR.
Title: Doublecortin-Like Kinases Promote Neuronal Survival and Induce Growth Cone Reformation via Distinct Mechanisms.
Doublecortin-like kinases are critical regulators of dendritic development by means of their specific targeting to the distal dendrites, and their local control of dendritic growth and synapse maturation.
Title: Doublecortin-like kinase enhances dendritic remodelling and negatively regulates synapse maturation.
Dcx; Dclk2-null mice display frequent spontaneous seizures that originate in the hippocampus, with most animals dying in the first few months of life.
Title: Mice lacking doublecortin and doublecortin-like kinase 2 display altered hippocampal neuronal maturation and spontaneous seizures.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)
Targeted (2) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

25.MMHAP29FLA4.seq (e-PCR)
- UniSTS:123680

AU044875 (e-PCR)
- UniSTS:159129

D3Ertd731e (e-PCR), detects polymorphism
- UniSTS:167371

UniSTS:234717 (e-PCR)
- UniSTS:234717

NoName (e-PCR)
- UniSTS:234718

NoName (e-PCR)
- UniSTS:234719

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables 3-phosphoinositide-dependent protein kinase activity	IEA Inferred from Electronic Annotation more info
enables AMP-activated protein kinase activity	IEA Inferred from Electronic Annotation more info
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables DNA-dependent protein kinase activity	IEA Inferred from Electronic Annotation more info
enables Rho-dependent protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info
enables eukaryotic translation initiation factor 2alpha kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AS1 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AS121 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AT120 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AXS139 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2BS14 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2BS36 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3S10 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3S28 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3S57 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T11 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T3 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T45 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T6 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H4S1 kinase activity	IEA Inferred from Electronic Annotation more info
enables microtubule binding	IDA Inferred from Direct Assay more info	PubMed
enables protein kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein serine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables ribosomal protein S6 kinase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in chromatin remodeling	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within hippocampus development	IGI Inferred from Genetic Interaction more info	PubMed
involved_in intracellular signal transduction	IEA Inferred from Electronic Annotation more info
involved_in microtubule cytoskeleton organization	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within microtubule cytoskeleton organization	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within negative regulation of protein localization to nucleus	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within peptidyl-serine phosphorylation	IDA Inferred from Direct Assay more info	PubMed
involved_in protein localization to nucleus	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of protein localization to nucleus	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within pyramidal neuron development	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: serine/threonine-protein kinase DCLK2

Names: caMK-like CREB regulatory kinase 2; doublecortin and CaM kinase-like 2; doublecortin-like and CAM kinase-like 2

NP_001182425.1

EC 2.7.11.1

NP_001182426.1

EC 2.7.11.1

NP_001182427.1

EC 2.7.11.1

NP_001182428.1

EC 2.7.11.1

NP_001182429.1

EC 2.7.11.1

NP_001344389.1

EC 2.7.11.1

NP_081815.3

EC 2.7.11.1

XP_006502129.1

EC 2.7.11.1

XP_006502130.1

EC 2.7.11.1

XP_006502131.1

EC 2.7.11.1

XP_006502132.1

EC 2.7.11.1

XP_006502133.1

EC 2.7.11.1

XP_006502134.1

EC 2.7.11.1

XP_006502135.1

EC 2.7.11.1

XP_006502136.1

EC 2.7.11.1

XP_006502137.1

EC 2.7.11.1

XP_006502138.1

EC 2.7.11.1

XP_006502139.1

EC 2.7.11.1

XP_006502140.1

EC 2.7.11.1

XP_006502141.1

EC 2.7.11.1

XP_011238528.1

EC 2.7.11.1

XP_011238529.1

EC 2.7.11.1

XP_017175208.1

EC 2.7.11.1

XP_030108678.1

EC 2.7.11.1

XP_030108679.1

EC 2.7.11.1

XP_030108680.1

EC 2.7.11.1

XP_030108681.1

EC 2.7.11.1

XP_030108682.1

EC 2.7.11.1

XP_030108683.1

EC 2.7.11.1

XP_036019200.1

EC 2.7.11.1

XP_036019201.1

EC 2.7.11.1

XP_036019202.1

EC 2.7.11.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001195496.1 → NP_001182425.1 serine/threonine-protein kinase DCLK2 isoform 1

See identical proteins and their annotated locations for NP_001182425.1

Status: REVIEWED

Description

Transcript Variant: This variant (1) is an exon-5-containing transcript (PMIDs:15611072 and 18075264), and encodes the longest isoform (1).

Source sequence(s)

AC102164, AC127237, AC132346

UniProtKB/TrEMBL

A0A0A6YX71

Conserved Domains (3) summary

smart00220
Location:408 → 665

S_TKc; Serine/Threonine protein kinases, catalytic domain

smart00537
Location:67 → 157

DCX; Domain in the Doublecortin (DCX) gene product

cl21453
Location:406 → 664

PKc_like; Protein Kinases, catalytic domain
NM_001195497.1 → NP_001182426.1 serine/threonine-protein kinase DCLK2 isoform 3

See identical proteins and their annotated locations for NP_001182426.1

Status: REVIEWED

Description

Transcript Variant: This variant (3) is an exon-5-lacking transcript (PMIDs:15611072 and 18075264). It lacks an in-frame coding exon, as compared to variant 1. The resulting isoform (3) lacks an internal segment, as compared to isoform 1.

Source sequence(s)

AK049179, BC056921, BQ771344, BY361646

Consensus CDS

CCDS79936.1

UniProtKB/TrEMBL

A0A0A6YX71

Related

ENSMUSP00000142267.2, ENSMUST00000195561.6

Conserved Domains (3) summary

smart00220
Location:392 → 649

S_TKc; Serine/Threonine protein kinases, catalytic domain

smart00537
Location:67 → 157

DCX; Domain in the Doublecortin (DCX) gene product

cl21453
Location:390 → 648

PKc_like; Protein Kinases, catalytic domain
NM_001195498.1 → NP_001182427.1 serine/threonine-protein kinase DCLK2 isoform 4

See identical proteins and their annotated locations for NP_001182427.1

Status: REVIEWED

Description

Transcript Variant: This variant (4) is an exon-5-containing and exon-17-containing transcript (PMIDs:15611072 and 18075264), and represents the longest transcript. It has an additional 3 nts at an alternate splice site and an additional exon in the 3' region, which results in frame-shift, as compared to variant 1. The resulting isoform (4) has an extra aa in the middle region and has a shorter and different C-terminus, as compared to isoform 1.

Source sequence(s)

AC102164, AC127237, AC132346

UniProtKB/TrEMBL

A0A0A6YX71

Conserved Domains (3) summary

smart00220
Location:409 → 666

S_TKc; Serine/Threonine protein kinases, catalytic domain

smart00537
Location:67 → 157

DCX; Domain in the Doublecortin (DCX) gene product

cl21453
Location:407 → 665

PKc_like; Protein Kinases, catalytic domain
NM_001195499.1 → NP_001182428.1 serine/threonine-protein kinase DCLK2 isoform 5

Status: REVIEWED

Description

Transcript Variant: This variant (5) is an exon-5-containing and exon-17-containing transcript (PMIDs:15611072 and 18075264). It has an additional exon in the 3' region, which results in frame-shift, as compared to variant 1. The resulting isoform (5) has a shorter and different C-terminus, as compared to isoform 1.

Source sequence(s)

AC102164, AC127237, AC132346

UniProtKB/TrEMBL

A0A0A6YX71

Conserved Domains (3) summary

smart00220
Location:408 → 665

S_TKc; Serine/Threonine protein kinases, catalytic domain

smart00537
Location:67 → 157

DCX; Domain in the Doublecortin (DCX) gene product

cl21453
Location:406 → 664

PKc_like; Protein Kinases, catalytic domain
NM_001195500.2 → NP_001182429.1 serine/threonine-protein kinase DCLK2 isoform 6

Status: REVIEWED

Description

Transcript Variant: This variant (6) is an exon-5-lacking transcript (PMIDs:15611072 and 18075264). It lacks an internal exon and several 3' exons, but has an alternate 3' segment, as compared to variant 1. The resulting isoform (6) lacks an internal segment and is C-terminal truncated, as compared to isoform 1.

Source sequence(s)

AK049126, BQ771344

Consensus CDS

CCDS79935.1

UniProtKB/TrEMBL

A0A0A6YWI6, A0A0A6YX33

Related

ENSMUSP00000141816.2, ENSMUST00000194452.2

Conserved Domains (3) summary

smart00220
Location:392 → 590

S_TKc; Serine/Threonine protein kinases, catalytic domain

smart00537
Location:67 → 157

DCX; Domain in the Doublecortin (DCX) gene product

cl21453
Location:390 → 590

PKc_like; Protein Kinases, catalytic domain
NM_001357460.1 → NP_001344389.1 serine/threonine-protein kinase DCLK2 isoform 7

Status: REVIEWED

Source sequence(s)

AC102164, AC127237, AC132346

UniProtKB/TrEMBL

A0A0A6YX71

Conserved Domains (2) summary

smart00537
Location:67 → 157

DCX; Domain in the Doublecortin (DCX) gene product

cl21453
Location:407 → 665

PKc_like; Protein Kinases, catalytic domain
NM_027539.5 → NP_081815.3 serine/threonine-protein kinase DCLK2 isoform 2

See identical proteins and their annotated locations for NP_081815.3

Status: REVIEWED

Description

Transcript Variant: This variant (2) is an exon-5-lacking transcript (PMIDs:15611072 and 18075264). It lacks an in-frame coding exon and has an additional 3 nts at an alternate splice site, as compared to variant 1. The resulting isoform (2) is shorter; it lacks an internal segment but has a downstream extra aa, as compared to isoform 1.

Source sequence(s)

BC056921, BQ771344, BY361646

Consensus CDS

CCDS17448.1

UniProtKB/Swiss-Prot

Q1EDG7, Q1EDG8, Q4H483, Q4W8V1, Q6PGN3, Q8BUU0, Q8BX25

UniProtKB/TrEMBL

A0A0A6YX71

Related

ENSMUSP00000029719.9, ENSMUST00000029719.14

Conserved Domains (3) summary

smart00220
Location:393 → 650

S_TKc; Serine/Threonine protein kinases, catalytic domain

smart00537
Location:67 → 157

DCX; Domain in the Doublecortin (DCX) gene product

cl21453
Location:391 → 649

PKc_like; Protein Kinases, catalytic domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000069.7 Reference GRCm39 C57BL/6J

Range

86693457..86828292 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_030252823.2 → XP_030108683.1 serine/threonine-protein kinase DCLK2 isoform X23

UniProtKB/TrEMBL

A0A0A6YWI6

Related

ENSMUSP00000141567.2, ENSMUST00000192773.6

Conserved Domains (3) summary

cd17069
Location:192 → 275

DCX2; Dublecortin-like domain 2

cd17141
Location:70 → 154

DCX1_DCLK2; Dublecortin-like domain 1 found in doublecortin-like kinase 2 (DCLK2)

cl21453
Location:390 → 637

PKc_like; Protein Kinases, catalytic domain
XM_030252818.2 → XP_030108678.1 serine/threonine-protein kinase DCLK2 isoform X5

UniProtKB/TrEMBL

A0A0A6YX71

Conserved Domains (3) summary

cd17069
Location:192 → 275

DCX2; Dublecortin-like domain 2

cd17141
Location:70 → 154

DCX1_DCLK2; Dublecortin-like domain 1 found in doublecortin-like kinase 2 (DCLK2)

cl21453
Location:390 → 638

PKc_like; Protein Kinases, catalytic domain
XM_030252821.2 → XP_030108681.1 serine/threonine-protein kinase DCLK2 isoform X18

UniProtKB/TrEMBL

A0A0A6YX71

Conserved Domains (3) summary

cd17069
Location:192 → 275

DCX2; Dublecortin-like domain 2

cd17141
Location:70 → 154

DCX1_DCLK2; Dublecortin-like domain 1 found in doublecortin-like kinase 2 (DCLK2)

cl21453
Location:390 → 648

PKc_like; Protein Kinases, catalytic domain
XM_006502071.4 → XP_006502134.1 serine/threonine-protein kinase DCLK2 isoform X10

UniProtKB/TrEMBL

A0A0A6YX71

Conserved Domains (3) summary

cd17069
Location:192 → 275

DCX2; Dublecortin-like domain 2

cd17141
Location:70 → 154

DCX1_DCLK2; Dublecortin-like domain 1 found in doublecortin-like kinase 2 (DCLK2)

cl21453
Location:390 → 648

PKc_like; Protein Kinases, catalytic domain
XM_030252822.2 → XP_030108682.1 serine/threonine-protein kinase DCLK2 isoform X22

UniProtKB/TrEMBL

A0A0A6YWI6

Conserved Domains (3) summary

cd17069
Location:192 → 275

DCX2; Dublecortin-like domain 2

cd17141
Location:70 → 154

DCX1_DCLK2; Dublecortin-like domain 1 found in doublecortin-like kinase 2 (DCLK2)

cl21453
Location:391 → 638

PKc_like; Protein Kinases, catalytic domain
XM_006502067.4 → XP_006502130.1 serine/threonine-protein kinase DCLK2 isoform X4

UniProtKB/TrEMBL

A0A0A6YX71

Conserved Domains (3) summary

cd17069
Location:192 → 275

DCX2; Dublecortin-like domain 2

cd17141
Location:70 → 154

DCX1_DCLK2; Dublecortin-like domain 1 found in doublecortin-like kinase 2 (DCLK2)

cl21453
Location:391 → 639

PKc_like; Protein Kinases, catalytic domain
XM_030252820.2 → XP_030108680.1 serine/threonine-protein kinase DCLK2 isoform X17

UniProtKB/TrEMBL

A0A0A6YX71

Conserved Domains (3) summary

cd17069
Location:192 → 275

DCX2; Dublecortin-like domain 2

cd17141
Location:70 → 154

DCX1_DCLK2; Dublecortin-like domain 1 found in doublecortin-like kinase 2 (DCLK2)

cl21453
Location:391 → 649

PKc_like; Protein Kinases, catalytic domain
XM_030252819.2 → XP_030108679.1 serine/threonine-protein kinase DCLK2 isoform X9

UniProtKB/TrEMBL

A0A0A6YX71

Conserved Domains (3) summary

cd17069
Location:192 → 275

DCX2; Dublecortin-like domain 2

cd17141
Location:70 → 154

DCX1_DCLK2; Dublecortin-like domain 1 found in doublecortin-like kinase 2 (DCLK2)

cl21453
Location:391 → 649

PKc_like; Protein Kinases, catalytic domain
XM_036163308.1 → XP_036019201.1 serine/threonine-protein kinase DCLK2 isoform X3

UniProtKB/TrEMBL

A0A0A6YX71

Conserved Domains (3) summary

cd17069
Location:192 → 275

DCX2; Dublecortin-like domain 2

cd17141
Location:70 → 154

DCX1_DCLK2; Dublecortin-like domain 1 found in doublecortin-like kinase 2 (DCLK2)

cl21453
Location:406 → 654

PKc_like; Protein Kinases, catalytic domain
XM_036163309.1 → XP_036019202.1 serine/threonine-protein kinase DCLK2 isoform X13

UniProtKB/TrEMBL

A0A0A6YX71

Conserved Domains (3) summary

cd17069
Location:192 → 275

DCX2; Dublecortin-like domain 2

cd17141
Location:70 → 154

DCX1_DCLK2; Dublecortin-like domain 1 found in doublecortin-like kinase 2 (DCLK2)

cl21453
Location:406 → 664

PKc_like; Protein Kinases, catalytic domain
XM_011240226.3 → XP_011238528.1 serine/threonine-protein kinase DCLK2 isoform X11

UniProtKB/TrEMBL

A0A0A6YWI6

Conserved Domains (3) summary

cd17069
Location:192 → 275

DCX2; Dublecortin-like domain 2

cd17141
Location:70 → 154

DCX1_DCLK2; Dublecortin-like domain 1 found in doublecortin-like kinase 2 (DCLK2)

cl21453
Location:407 → 607

PKc_like; Protein Kinases, catalytic domain
XM_017319719.3 → XP_017175208.1 serine/threonine-protein kinase DCLK2 isoform X24

UniProtKB/TrEMBL

A0A0A6YWI6

Conserved Domains (3) summary

cd17069
Location:192 → 275

DCX2; Dublecortin-like domain 2

cd17141
Location:70 → 154

DCX1_DCLK2; Dublecortin-like domain 1 found in doublecortin-like kinase 2 (DCLK2)

cl21453
Location:407 → 607

PKc_like; Protein Kinases, catalytic domain
XM_011240227.3 → XP_011238529.1 serine/threonine-protein kinase DCLK2 isoform X25

UniProtKB/TrEMBL

A0A0A6YWI6

Conserved Domains (3) summary

cd17069
Location:192 → 275

DCX2; Dublecortin-like domain 2

cd17141
Location:70 → 154

DCX1_DCLK2; Dublecortin-like domain 1 found in doublecortin-like kinase 2 (DCLK2)

cl21453
Location:407 → 607

PKc_like; Protein Kinases, catalytic domain
XM_006502076.4 → XP_006502139.1 serine/threonine-protein kinase DCLK2 isoform X19

UniProtKB/TrEMBL

A0A0A6YWI6

Conserved Domains (3) summary

cd17069
Location:192 → 275

DCX2; Dublecortin-like domain 2

cd17141
Location:70 → 154

DCX1_DCLK2; Dublecortin-like domain 1 found in doublecortin-like kinase 2 (DCLK2)

cl21453
Location:407 → 654

PKc_like; Protein Kinases, catalytic domain
XM_006502070.4 → XP_006502133.1 serine/threonine-protein kinase DCLK2 isoform X8

UniProtKB/TrEMBL

A0A0A6YWI6

Conserved Domains (3) summary

cd17069
Location:192 → 275

DCX2; Dublecortin-like domain 2

cd17141
Location:70 → 154

DCX1_DCLK2; Dublecortin-like domain 1 found in doublecortin-like kinase 2 (DCLK2)

cl21453
Location:407 → 659

PKc_like; Protein Kinases, catalytic domain
XM_006502078.4 → XP_006502141.1 serine/threonine-protein kinase DCLK2 isoform X21

UniProtKB/TrEMBL

A0A0A6YWI6

Conserved Domains (3) summary

cd17069
Location:192 → 275

DCX2; Dublecortin-like domain 2

cd17141
Location:70 → 154

DCX1_DCLK2; Dublecortin-like domain 1 found in doublecortin-like kinase 2 (DCLK2)

cl21453
Location:407 → 654

PKc_like; Protein Kinases, catalytic domain
XM_006502066.4 → XP_006502129.1 serine/threonine-protein kinase DCLK2 isoform X2

UniProtKB/TrEMBL

A0A0A6YX71

Conserved Domains (3) summary

cd17069
Location:192 → 275

DCX2; Dublecortin-like domain 2

cd17141
Location:70 → 154

DCX1_DCLK2; Dublecortin-like domain 1 found in doublecortin-like kinase 2 (DCLK2)

cl21453
Location:407 → 655

PKc_like; Protein Kinases, catalytic domain
XM_006502074.4 → XP_006502137.1 serine/threonine-protein kinase DCLK2 isoform X15

UniProtKB/TrEMBL

A0A0A6YX71

Related

ENSMUSP00000141707.2, ENSMUST00000191752.6

Conserved Domains (3) summary

cd17069
Location:192 → 275

DCX2; Dublecortin-like domain 2

cd17141
Location:70 → 154

DCX1_DCLK2; Dublecortin-like domain 1 found in doublecortin-like kinase 2 (DCLK2)

cl21453
Location:407 → 655

PKc_like; Protein Kinases, catalytic domain
XM_006502072.4 → XP_006502135.1 serine/threonine-protein kinase DCLK2 isoform X12

UniProtKB/TrEMBL

A0A0A6YX71

Conserved Domains (3) summary

cd17069
Location:192 → 275

DCX2; Dublecortin-like domain 2

cd17141
Location:70 → 154

DCX1_DCLK2; Dublecortin-like domain 1 found in doublecortin-like kinase 2 (DCLK2)

cl21453
Location:407 → 665

PKc_like; Protein Kinases, catalytic domain
XM_006502068.4 → XP_006502131.1 serine/threonine-protein kinase DCLK2 isoform X6

UniProtKB/TrEMBL

A0A0A6YX71

Conserved Domains (3) summary

cd17069
Location:192 → 275

DCX2; Dublecortin-like domain 2

cd17141
Location:70 → 154

DCX1_DCLK2; Dublecortin-like domain 1 found in doublecortin-like kinase 2 (DCLK2)

cl21453
Location:407 → 665

PKc_like; Protein Kinases, catalytic domain
XM_006502075.4 → XP_006502138.1 serine/threonine-protein kinase DCLK2 isoform X16

UniProtKB/TrEMBL

A0A0A6YX71

Conserved Domains (3) summary

cd17069
Location:192 → 275

DCX2; Dublecortin-like domain 2

cd17141
Location:70 → 154

DCX1_DCLK2; Dublecortin-like domain 1 found in doublecortin-like kinase 2 (DCLK2)

cl21453
Location:407 → 665

PKc_like; Protein Kinases, catalytic domain
XM_006502069.4 → XP_006502132.1 serine/threonine-protein kinase DCLK2 isoform X7

UniProtKB/TrEMBL

A0A0A6YX71

Conserved Domains (3) summary

cd17069
Location:192 → 275

DCX2; Dublecortin-like domain 2

cd17141
Location:70 → 154

DCX1_DCLK2; Dublecortin-like domain 1 found in doublecortin-like kinase 2 (DCLK2)

cl21453
Location:407 → 665

PKc_like; Protein Kinases, catalytic domain
XM_006502077.4 → XP_006502140.1 serine/threonine-protein kinase DCLK2 isoform X20

UniProtKB/TrEMBL

A0A0A6YWI6

Conserved Domains (3) summary

cd17069
Location:192 → 275

DCX2; Dublecortin-like domain 2

cd17141
Location:70 → 154

DCX1_DCLK2; Dublecortin-like domain 1 found in doublecortin-like kinase 2 (DCLK2)

cl21453
Location:407 → 655

PKc_like; Protein Kinases, catalytic domain
XM_006502073.4 → XP_006502136.1 serine/threonine-protein kinase DCLK2 isoform X14

UniProtKB/TrEMBL

A0A0A6YX71

Related

ENSMUSP00000141866.2, ENSMUST00000193632.6

Conserved Domains (3) summary

cd17069
Location:192 → 275

DCX2; Dublecortin-like domain 2

cd17141
Location:70 → 154

DCX1_DCLK2; Dublecortin-like domain 1 found in doublecortin-like kinase 2 (DCLK2)

cl21453
Location:407 → 665

PKc_like; Protein Kinases, catalytic domain
XM_036163307.1 → XP_036019200.1 serine/threonine-protein kinase DCLK2 isoform X1

UniProtKB/TrEMBL

A0A0A6YWI6

Conserved Domains (3) summary

cd17069
Location:192 → 275

DCX2; Dublecortin-like domain 2

cd17141
Location:70 → 154

DCX1_DCLK2; Dublecortin-like domain 1 found in doublecortin-like kinase 2 (DCLK2)

cl21453
Location:390 → 648

PKc_like; Protein Kinases, catalytic domain