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    Cyp3a16 cytochrome P450, family 3, subfamily a, polypeptide 16 [ Mus musculus (house mouse) ]

    Gene ID: 13114, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Cyp3a16provided by MGI
    Official Full Name
    cytochrome P450, family 3, subfamily a, polypeptide 16provided by MGI
    Primary source
    MGI:MGI:106099
    See related
    Ensembl:ENSMUSG00000038656 AllianceGenome:MGI:106099
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Predicted to enable demethylase activity; retinoic acid 4-hydroxylase activity; and steroid hydroxylase activity. Predicted to be involved in several processes, including estrogen metabolic process; lipid hydroxylation; and retinoic acid metabolic process. Predicted to be located in endoplasmic reticulum membrane. Is expressed in liver. Human ortholog(s) of this gene implicated in B-lymphoblastic leukemia/lymphoma; acute lymphoblastic leukemia; chronic myeloid leukemia; and essential hypertension. Orthologous to human CYP3A5 (cytochrome P450 family 3 subfamily A member 5). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in liver E18 (RPKM 54.3), liver adult (RPKM 12.3) and 2 other tissues See more
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    Genomic context

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    See Cyp3a16 in Genome Data Viewer
    Location:
    5 G2; 5 85.17 cM
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (145373119..145406550, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (145436309..145469740, complement)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene cytochrome P450, family 3, subfamily a, polypeptide 57 Neighboring gene STARR-seq mESC enhancer starr_14833 Neighboring gene sperm motility kinase 3A pseudogene Neighboring gene cytochrome P450, family 3, subfamily a, member 58, pseudogene Neighboring gene zinc finger protein 498 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Dynamic patterns of histone methylation are associated with ontogenic expression of the Cyp3a genes during mouse liver maturation. Li Y, et al. Mol Pharmacol, 2009 May. PMID 19188337, Free PMC Article
    2. Isolation of a promoter region in mouse cytochrome P450 3A (Cyp3A16) gene and its transcriptional control. Itoh S, et al. Biochim Biophys Acta, 1997 Feb 7. PMID 9048885
    3. A novel form of mouse cytochrome P450 3A (Cyp3a-16). Its cDNA cloning and expression in fetal liver. Itoh S, et al. Eur J Biochem, 1994 Dec 15. PMID 7813478
    4. A map of the mouse Cyp3a locus. Zaphiropoulos PG. DNA Seq, 2003 Jun. PMID 14509827
    5. The steroid and xenobiotic receptor negatively regulates B-1 cell development in the fetal liver. Casey SC, et al. Mol Endocrinol, 2012 Jun. PMID 22496360, Free PMC Article

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Dynamic patterns of histone methylation are associated with ontogenic expression of the Cyp3a genes during mouse liver maturation.
      Title: Dynamic patterns of histone methylation are associated with ontogenic expression of the Cyp3a genes during mouse liver maturation.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Clone Names

    • MGC130513

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables demethylase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables estrogen 16-alpha-hydroxylase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables heme binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables iron ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables monooxygenase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables oxidoreductase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables retinoic acid 4-hydroxylase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables testosterone 6-beta-hydroxylase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables testosterone 6-beta-hydroxylase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in alkaloid catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in estrogen metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in lipid hydroxylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in oxidative demethylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in oxidative demethylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in retinoic acid metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in steroid metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in steroid metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in xenobiotic catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    cytochrome P450 3A16
    Names
    CYPIIIA16
    cytochrome P450, 3a16
    NP_031846.2
    XP_006504862.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_007820.2 → NP_031846.2  cytochrome P450 3A16

      See identical proteins and their annotated locations for NP_031846.2

      Status: VALIDATED

      Source sequence(s)
      AC115895, BC113143, BY772732
      Consensus CDS
      CCDS19862.1
      UniProtKB/Swiss-Prot
      E9QP65, Q64481
      UniProtKB/TrEMBL
      Q2KHL4
      Related
      ENSMUSP00000031633.5, ENSMUST00000031633.5
      Conserved Domains (1) summary
      cd20650
      Location:67 → 493
      CYP3A; cytochrome P450 family 3, subfamily A

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      145373119..145406550 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006504799.4 → XP_006504862.1  cytochrome P450 3A16 isoform X1

      UniProtKB/TrEMBL
      Q2KHL4
      Conserved Domains (1) summary
      pfam00067
      Location:39 → 474
      p450; Cytochrome P450
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q64481.2 GenPept UniProtKB/Swiss-Prot:Q64481

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