Adamts9 ADAM metallopeptidase with thrombospondin type 1 motif 9 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Adamts9provided by MGI
Official Full Name: ADAM metallopeptidase with thrombospondin type 1 motif 9provided by MGI
Primary source: MGI:MGI:1916320
See related: Ensembl:ENSMUSG00000030022 AllianceGenome:MGI:1916320
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: UND3; UND4; Gsfund3; Mhdaund3; Mhdaund4; 1810011L16Rik; 8430403M15Rik; E030027K14Rik
Summary: Enables endopeptidase activity. Involved in several processes, including circulatory system development; negative regulation of endothelial cell migration; and negative regulation of sprouting angiogenesis. Acts upstream of or within several processes, including camera-type eye development; positive regulation of melanocyte differentiation; and response to bacterium. Located in cell surface and extracellular space. Is expressed in several structures, including alimentary system; embryo mesenchyme; endocrine gland; eye; and genitourinary system. Orthologous to human ADAMTS9 (ADAM metallopeptidase with thrombospondin type 1 motif 9). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Broad expression in limb E14.5 (RPKM 5.9), subcutaneous fat pad adult (RPKM 3.5) and 22 other tissues See more
Orthologs: human all
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Genomic context

Location:: 6 D1; 6 41.41 cM

Exon count:: 40

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	6	NC_000072.7 (92749680..92921431, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	6	NC_000072.6 (92772699..92944450, complement)

Chromosome 6 - NC_000072.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

LncRNA ADAMTS9-AS2 regulates periodontal ligament cell migration under mechanical compression via ADAMTS9/fibronectin.
Title: LncRNA ADAMTS9-AS2 regulates periodontal ligament cell migration under mechanical compression via ADAMTS9/fibronectin.
Long noncoding RNA ADAMTS9-AS1 represses ferroptosis of endometrial stromal cells by regulating the miR-6516-5p/GPX4 axis in endometriosis.
Title: Long noncoding RNA ADAMTS9-AS1 represses ferroptosis of endometrial stromal cells by regulating the miR-6516-5p/GPX4 axis in endometriosis.
Results provide compelling evidence that ADAMTS9 and ADAMTS20 were differentially sensitive to B3GLCT inactivation and suggest that the developmental defects in PTRPLS result from disruption of a subset of highly sensitive POFUT2/B3GLCT targets such as ADAMTS20.
Title: ADAMTS9 and ADAMTS20 are differentially affected by loss of B3GLCT in mouse model of Peters plus syndrome.
ADAMTS9 Regulates Skeletal Muscle Insulin Sensitivity Through Extracellular Matrix Alterations.
Title: ADAMTS9 Regulates Skeletal Muscle Insulin Sensitivity Through Extracellular Matrix Alterations.
ADAMTS9 or ADAMTS20 mutagenesis impaired neural and yolk sac ciliogenesis, leading to morphogenetic anomalies resulting from impaired hedgehog signaling, which is transduced by primary cilia.
Title: Secreted metalloproteases ADAMTS9 and ADAMTS20 have a non-canonical role in ciliary vesicle growth during ciliogenesis.
there is a melanocyte cell-autonomous requirement for Adamts9.
Title: Melanocyte development in the mouse tail epidermis requires the Adamts9 metalloproteinase.
Extracellular matrix dynamics is a major influence on umbilical vascular SMC fate, with ADAMTS9 acting as its principal mediator.
Title: ADAMTS9-Mediated Extracellular Matrix Dynamics Regulates Umbilical Cord Vascular Smooth Muscle Differentiation and Rotation.
The present study reveals ADAMT-9 expression by mast cells(MCs) and that MC activation regulates the expression of the protease, thus implicating the ADAMT-9 of protease in MC function.
Title: ADAMTS: novel proteases expressed by activated mast cells.
Western blot analyses indicated that aggrecanase-generated proteoglycan fragments are produced after SCI.
Title: ADAMTS1, ADAMTS5, ADAMTS9 and aggrecanase-generated proteoglycan fragments are induced following spinal cord injury in mouse.
These findings support a model in which cooperative versican proteolysis by ADAMTS9 in vascular endothelium and by ADAMTS20 in palate mesenchyme drives palatal shelf sculpting and extension.
Title: Cooperation of two ADAMTS metalloproteases in closure of the mouse palate identifies a requirement for versican proteolysis in regulating palatal mesenchyme proliferation.

Submit: New GeneRIF Correction See all GeneRIFs (14)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Chemically induced (ENU) (2)
Endonuclease-mediated (1)
Gene trapped (1)
Targeted (9) 1 citation

General gene information

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Markers

NoName (e-PCR)
- UniSTS:548432

BE199318 (e-PCR)
- UniSTS:207999

AW743315 (e-PCR)
- UniSTS:208000

Adamts9 (e-PCR), detects polymorphism
- UniSTS:532656

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables endopeptidase activity	IDA Inferred from Direct Assay more info	PubMed
enables metalloendopeptidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables metalloendopeptidase activity	IEA Inferred from Electronic Annotation more info
enables metallopeptidase activity	ISO Inferred from Sequence Orthology more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in aorta morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within camera-type eye morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cornea development in camera-type eye	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in endothelial cell-matrix adhesion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in extracellular matrix organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in extracellular matrix organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in heart valve morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within lens development in camera-type eye	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of melanocyte differentiation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of endothelial cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of sprouting angiogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of melanocyte differentiation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in proteolysis	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within proteolysis	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within proteolysis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of developmental pigmentation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within response to bacterium	IEP Inferred from Expression Pattern more info	PubMed
involved_in ventricular cardiac muscle tissue development	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cell surface	IDA Inferred from Direct Assay more info	PubMed
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
is_active_in extracellular matrix	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular matrix	ISO Inferred from Sequence Orthology more info
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: A disintegrin and metalloproteinase with thrombospondin motifs 9

Names: a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 9; a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 9

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_175314.4 → NP_780523.3 A disintegrin and metalloproteinase with thrombospondin motifs 9 precursor

Status: VALIDATED

Source sequence(s)

AC110378, AC166101

Consensus CDS

CCDS51855.2

UniProtKB/TrEMBL

E9PUN6

Related

ENSMUSP00000109065.2, ENSMUST00000113438.8

Conserved Domains (5) summary

smart00209
Location:591 → 642

TSP1; Thrombospondin type 1 repeats

cd04273
Location:293 → 496

ZnMc_ADAMTS_like; Zinc-dependent metalloprotease, ADAMTS_like subgroup. ADAMs (A Disintegrin And Metalloprotease) are glycoproteins, which play roles in cell signaling, cell fusion, and cell-cell interactions. This particular subfamily represents domain architectures that ...

pfam05986
Location:753 → 871

ADAM_spacer1; ADAM-TS Spacer 1

pfam01562
Location:49 → 207

Pep_M12B_propep; Reprolysin family propeptide

pfam08685
Location:1734 → 1930

GON; GON domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000072.7 Reference GRCm39 C57BL/6J

Range

92749680..92921431 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036165715.1 → XP_036021608.1 A disintegrin and metalloproteinase with thrombospondin motifs 9 isoform X5

Conserved Domains (7) summary

smart00209
Location:591 → 642

TSP1; Thrombospondin type 1 repeats

cd04273
Location:293 → 496

ZnMc_ADAMTS_like; Zinc-dependent metalloprotease, ADAMTS_like subgroup. ADAMs (A Disintegrin And Metalloprotease) are glycoproteins, which play roles in cell signaling, cell fusion, and cell-cell interactions. This particular subfamily represents domain architectures that ...

pfam05986
Location:753 → 871

ADAM_spacer1; ADAM-TS Spacer 1

pfam01562
Location:49 → 207

Pep_M12B_propep; Reprolysin family propeptide

pfam08685
Location:1639 → 1835

GON; GON domain

pfam17771
Location:511 → 578

ADAM_CR_2; ADAM cysteine-rich domain

pfam19030
Location:1287 → 1340

TSP1_ADAMTS; Thrombospondin type 1 domain
XM_036165714.1 → XP_036021607.1 A disintegrin and metalloproteinase with thrombospondin motifs 9 isoform X2

Conserved Domains (7) summary

smart00209
Location:591 → 642

TSP1; Thrombospondin type 1 repeats

cd04273
Location:293 → 496

ZnMc_ADAMTS_like; Zinc-dependent metalloprotease, ADAMTS_like subgroup. ADAMs (A Disintegrin And Metalloprotease) are glycoproteins, which play roles in cell signaling, cell fusion, and cell-cell interactions. This particular subfamily represents domain architectures that ...

pfam05986
Location:753 → 871

ADAM_spacer1; ADAM-TS Spacer 1

pfam01562
Location:49 → 207

Pep_M12B_propep; Reprolysin family propeptide

pfam08685
Location:1679 → 1875

GON; GON domain

pfam17771
Location:511 → 578

ADAM_CR_2; ADAM cysteine-rich domain

pfam19030
Location:1056 → 1110

TSP1_ADAMTS; Thrombospondin type 1 domain
XM_036165713.1 → XP_036021606.1 A disintegrin and metalloproteinase with thrombospondin motifs 9 isoform X1

Conserved Domains (7) summary

smart00209
Location:591 → 642

TSP1; Thrombospondin type 1 repeats

cd04273
Location:293 → 496

ZnMc_ADAMTS_like; Zinc-dependent metalloprotease, ADAMTS_like subgroup. ADAMs (A Disintegrin And Metalloprotease) are glycoproteins, which play roles in cell signaling, cell fusion, and cell-cell interactions. This particular subfamily represents domain architectures that ...

pfam05986
Location:753 → 871

ADAM_spacer1; ADAM-TS Spacer 1

pfam01562
Location:49 → 207

Pep_M12B_propep; Reprolysin family propeptide

pfam08685
Location:1694 → 1890

GON; GON domain

pfam17771
Location:511 → 578

ADAM_CR_2; ADAM cysteine-rich domain

pfam19030
Location:1342 → 1395

TSP1_ADAMTS; Thrombospondin type 1 domain
XM_006505263.4 → XP_006505326.1 A disintegrin and metalloproteinase with thrombospondin motifs 9 isoform X6

Conserved Domains (6) summary

smart00209
Location:591 → 642

TSP1; Thrombospondin type 1 repeats

cd04273
Location:293 → 496

ZnMc_ADAMTS_like; Zinc-dependent metalloprotease, ADAMTS_like subgroup. ADAMs (A Disintegrin And Metalloprotease) are glycoproteins, which play roles in cell signaling, cell fusion, and cell-cell interactions. This particular subfamily represents domain architectures that ...

pfam01562
Location:49 → 207

Pep_M12B_propep; Reprolysin family propeptide

pfam05986
Location:753 → 871

ADAM_spacer1; ADAM-TS Spacer 1

pfam08685
Location:1620 → 1816

GON; GON domain

pfam17771
Location:511 → 578

ADAM_CR_2; ADAM cysteine-rich domain
XM_006505261.4 → XP_006505324.1 A disintegrin and metalloproteinase with thrombospondin motifs 9 isoform X3

Conserved Domains (6) summary

smart00209
Location:591 → 642

TSP1; Thrombospondin type 1 repeats

cd04273
Location:293 → 496

ZnMc_ADAMTS_like; Zinc-dependent metalloprotease, ADAMTS_like subgroup. ADAMs (A Disintegrin And Metalloprotease) are glycoproteins, which play roles in cell signaling, cell fusion, and cell-cell interactions. This particular subfamily represents domain architectures that ...

pfam01562
Location:49 → 207

Pep_M12B_propep; Reprolysin family propeptide

pfam05986
Location:753 → 871

ADAM_spacer1; ADAM-TS Spacer 1

pfam08685
Location:1678 → 1874

GON; GON domain

pfam17771
Location:511 → 578

ADAM_CR_2; ADAM cysteine-rich domain
XM_006505262.4 → XP_006505325.1 A disintegrin and metalloproteinase with thrombospondin motifs 9 isoform X4

Conserved Domains (6) summary

smart00209
Location:591 → 642

TSP1; Thrombospondin type 1 repeats

cd04273
Location:293 → 496

ZnMc_ADAMTS_like; Zinc-dependent metalloprotease, ADAMTS_like subgroup. ADAMs (A Disintegrin And Metalloprotease) are glycoproteins, which play roles in cell signaling, cell fusion, and cell-cell interactions. This particular subfamily represents domain architectures that ...

pfam01562
Location:49 → 207

Pep_M12B_propep; Reprolysin family propeptide

pfam05986
Location:753 → 871

ADAM_spacer1; ADAM-TS Spacer 1

pfam08685
Location:1676 → 1872

GON; GON domain

pfam17771
Location:511 → 578

ADAM_CR_2; ADAM cysteine-rich domain