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    Nlrp9b NLR family, pyrin domain containing 9B [ Mus musculus (house mouse) ]

    Gene ID: 243874, updated on 9-Dec-2024

    Summary

    Official Symbol
    Nlrp9bprovided by MGI
    Official Full Name
    NLR family, pyrin domain containing 9Bprovided by MGI
    Primary source
    MGI:MGI:2675377
    See related
    Ensembl:ENSMUSG00000060508 AllianceGenome:MGI:2675377
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Nlrp9; Nalp9b; Nalp-delta
    Summary
    Predicted to enable ATP binding activity. Involved in defense response to symbiont; positive regulation of interleukin-18 production; and pyroptotic inflammatory response. Acts upstream of or within blastocyst development. Predicted to be part of canonical inflammasome complex. Predicted to be active in cytoplasm. Is expressed in early conceptus; intestine; ovary; and testis. Orthologous to human NLRP9 (NLR family pyrin domain containing 9). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in large intestine adult (RPKM 5.3), small intestine adult (RPKM 1.7) and 4 other tissues See more
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    Genomic context

    See Nlrp9b in Genome Data Viewer
    Location:
    7 A3; 7 9.96 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (19725318..19796867)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (19991393..20062942)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene ribosomal protein L7A, pseudogene 8 Neighboring gene CEA cell adhesion molecule 20 Neighboring gene STARR-seq mESC enhancer starr_18236 Neighboring gene nuclear encoded rRNA 5S 152 Neighboring gene predicted gene 8432 Neighboring gene STARR-seq mESC enhancer starr_18237 Neighboring gene chromobox homolog 3 pseudogene Neighboring gene vomeronasal 1 receptor 91

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within blastocyst development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in defense response to virus IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in innate immune response IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of interleukin-18 production IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in pyroptotic inflammatory response IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of inflammatory response IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    part_of canonical inflammasome complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of canonical inflammasome complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of canonical inflammasome complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    NACHT, LRR and PYD domains-containing protein 9B
    Names
    NACHT, LRR and PYD containing protein 9b
    NLR family, pyrin domain containing 9

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_194058.2NP_918947.2  NACHT, LRR and PYD domains-containing protein 9B

      See identical proteins and their annotated locations for NP_918947.2

      Status: VALIDATED

      Source sequence(s)
      AY596196
      Consensus CDS
      CCDS20920.1
      UniProtKB/Swiss-Prot
      Q66X22, Q6UTW9
      UniProtKB/TrEMBL
      B9EIZ9
      Related
      ENSMUSP00000072895.7, ENSMUST00000073151.13
      Conserved Domains (6) summary
      cd08320
      Location:986
      Pyrin_NALPs; Pyrin death domain found in NALP proteins
      sd00033
      Location:694722
      LRR_RI; leucine-rich repeat [structural motif]
      pfam05729
      Location:144308
      NACHT; NACHT domain
      pfam17776
      Location:440555
      NLRC4_HD2; NLRC4 helical domain HD2
      pfam17779
      Location:387438
      NOD2_WH; NOD2 winged helix domain
      cl39015
      Location:752955
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      19725318..19796867
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006539938.2XP_006540001.1  NACHT, LRR and PYD domains-containing protein 9B isoform X1

      See identical proteins and their annotated locations for XP_006540001.1

      UniProtKB/Swiss-Prot
      Q66X22, Q6UTW9
      UniProtKB/TrEMBL
      B9EIZ9
      Conserved Domains (6) summary
      cd08320
      Location:986
      Pyrin_NALPs; Pyrin death domain found in NALP proteins
      sd00033
      Location:694722
      LRR_RI; leucine-rich repeat [structural motif]
      pfam05729
      Location:144308
      NACHT; NACHT domain
      pfam17776
      Location:440555
      NLRC4_HD2; NLRC4 helical domain HD2
      pfam17779
      Location:387438
      NOD2_WH; NOD2 winged helix domain
      cl39015
      Location:752955
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    2. XM_006539939.2XP_006540002.1  NACHT, LRR and PYD domains-containing protein 9B isoform X1

      See identical proteins and their annotated locations for XP_006540002.1

      UniProtKB/Swiss-Prot
      Q66X22, Q6UTW9
      UniProtKB/TrEMBL
      B9EIZ9
      Conserved Domains (6) summary
      cd08320
      Location:986
      Pyrin_NALPs; Pyrin death domain found in NALP proteins
      sd00033
      Location:694722
      LRR_RI; leucine-rich repeat [structural motif]
      pfam05729
      Location:144308
      NACHT; NACHT domain
      pfam17776
      Location:440555
      NLRC4_HD2; NLRC4 helical domain HD2
      pfam17779
      Location:387438
      NOD2_WH; NOD2 winged helix domain
      cl39015
      Location:752955
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    3. XM_011250564.1XP_011248866.1  NACHT, LRR and PYD domains-containing protein 9B isoform X3

      UniProtKB/TrEMBL
      B9EIZ9
      Conserved Domains (6) summary
      cd08320
      Location:986
      Pyrin_NALPs; Pyrin death domain found in NALP proteins
      sd00034
      Location:633667
      LRR_AMN1; leucine-rich repeat [structural motif]
      pfam05729
      Location:144308
      NACHT; NACHT domain
      pfam17776
      Location:440555
      NLRC4_HD2; NLRC4 helical domain HD2
      pfam17779
      Location:387438
      NOD2_WH; NOD2 winged helix domain
      cl39015
      Location:692899
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    4. XM_011250563.1XP_011248865.1  NACHT, LRR and PYD domains-containing protein 9B isoform X2

      UniProtKB/TrEMBL
      B9EIZ9
      Conserved Domains (6) summary
      cd08320
      Location:986
      Pyrin_NALPs; Pyrin death domain found in NALP proteins
      sd00033
      Location:639667
      LRR_RI; leucine-rich repeat [structural motif]
      pfam05729
      Location:144308
      NACHT; NACHT domain
      pfam17776
      Location:440555
      NLRC4_HD2; NLRC4 helical domain HD2
      pfam17779
      Location:387438
      NOD2_WH; NOD2 winged helix domain
      cl39015
      Location:697900
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    5. XM_011250565.1XP_011248867.1  NACHT, LRR and PYD domains-containing protein 9B isoform X4

      UniProtKB/TrEMBL
      B9EIZ9
      Conserved Domains (6) summary
      cd08320
      Location:986
      Pyrin_NALPs; Pyrin death domain found in NALP proteins
      sd00034
      Location:633667
      LRR_AMN1; leucine-rich repeat [structural motif]
      pfam05729
      Location:144308
      NACHT; NACHT domain
      pfam17776
      Location:440555
      NLRC4_HD2; NLRC4 helical domain HD2
      pfam17779
      Location:387438
      NOD2_WH; NOD2 winged helix domain
      cl39015
      Location:692839
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...