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    Islr immunoglobulin superfamily containing leucine-rich repeat [ Mus musculus (house mouse) ]

    Gene ID: 26968, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Islrprovided by MGI
    Official Full Name
    immunoglobulin superfamily containing leucine-rich repeatprovided by MGI
    Primary source
    MGI:MGI:1349645
    See related
    Ensembl:ENSMUSG00000037206 AllianceGenome:MGI:1349645
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Meflin
    Summary
    Located in extracellular space. Is expressed in several structures, including embryo mesenchyme; genitourinary system; gut gland; meninges; and retina layer. Orthologous to human ISLR (immunoglobulin superfamily containing leucine rich repeat). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in limb E14.5 (RPKM 168.1), mammary gland adult (RPKM 124.5) and 20 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Islr in Genome Data Viewer
    Location:
    9 B; 9 31.63 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (58063547..58066563, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (58156246..58159236, complement)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene coiled-coil domain containing 33 Neighboring gene predicted gene 16130 Neighboring gene stimulated by retinoic acid gene 6 Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:57960192-57960379 Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:57981876-57982059 Neighboring gene predicted gene, 39344 Neighboring gene ribosomal protein L17 pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E10552 Neighboring gene immunoglobulin superfamily containing leucine-rich repeat 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Islr regulates satellite cells asymmetric division through the SPARC/p-ERK1/2 signaling pathway. Liu F, et al. FASEB J, 2024 Apr 15. PMID 38597911
    2. Pharmacologic conversion of cancer-associated fibroblasts from a protumor phenotype to an antitumor phenotype improves the sensitivity of pancreatic cancer to chemotherapeutics. Iida T, et al. Oncogene, 2022 May. PMID 35414659
    3. Cancer-associated fibroblasts that restrain cancer progression: Hypotheses and perspectives. Miyai Y, et al. Cancer Sci, 2020 Apr. PMID 32060987, Free PMC Article
    4. Meflin defines mesenchymal stem cells and/or their early progenitors with multilineage differentiation capacity. Hara A, et al. Genes Cells, 2021 Jul. PMID 33960573, Free PMC Article
    5. Human and mouse ISLR (immunoglobulin superfamily containing leucine-rich repeat) genes: genomic structure and tissue expression. Nagasawa A, et al. Genomics, 1999 Oct 1. PMID 10512678

    See all (33) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Islr regulates satellite cells asymmetric division through the SPARC/p-ERK1/2 signaling pathway.
      Title: Islr regulates satellite cells asymmetric division through the SPARC/p-ERK1/2 signaling pathway.
    2. Meflin is a marker of pancreatic stellate cells involved in fibrosis and epithelial regeneration in the pancreas.
      Title: Meflin is a marker of pancreatic stellate cells involved in fibrosis and epithelial regeneration in the pancreas.
    3. Islr regulates insulin sensitivity by interacting with Psma4 to control insulin receptor alpha levels in obese mice.
      Title: Islr regulates insulin sensitivity by interacting with Psma4 to control insulin receptor alpha levels in obese mice.
    4. Meflin defines mesenchymal stem cells and/or their early progenitors with multilineage differentiation capacity.
      Title: Meflin defines mesenchymal stem cells and/or their early progenitors with multilineage differentiation capacity.
    5. Meflin deficiency led to significant tumor progression with poorly differentiated histology in a PDAC mouse model. Meflin deficiency or low expression resulted in straightened stromal collagen fibers, which represent a signature for aggressive tumors, in mousePDAC tissues.
      Title: Meflin-Positive Cancer-Associated Fibroblasts Inhibit Pancreatic Carcinogenesis.
    6. Meflin interacts with bone morphogenetic protein 7. Meflin knockout mice developed marked cardiac interstitial fibrosis with defective compensation mechanisms.
      Title: Roles of the Mesenchymal Stromal/Stem Cell Marker Meflin in Cardiac Tissue Repair and the Development of Diastolic Dysfunction.
    7. Immunoglobulin superfamily containing leucine-rich repeat protein (Islr) interacts with Dishevelled-2 (Dvl2) to activate canonical Wnt signaling.
      Title: Islr regulates canonical Wnt signaling-mediated skeletal muscle regeneration by stabilizing Dishevelled-2 and preventing autophagy.
    8. Those results are consistent with a decrease in the number of clonogenic colony-forming unit-fibroblasts within the BM of Meflin-deficient mice. These preliminary data suggest that Meflin is a potential marker for cultured MSCs and their source cells in vivo.
      Title: Identification of Meflin as a Potential Marker for Mesenchymal Stromal Cells.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (5)  1 citation

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Component Evidence Code Pubs
    located_in extracellular space HDA PubMed 

    General protein information

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    Preferred Names
    immunoglobulin superfamily containing leucine-rich repeat protein
    Names
    mesenchymal stromal cell- and fibroblast-expressing Linx paralogue

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001195431.1 → NP_001182360.1  immunoglobulin superfamily containing leucine-rich repeat protein precursor

      See identical proteins and their annotated locations for NP_001182360.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses a different segment for its 5' UTR, compared to variant 1. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      AC158996, AC160976, AI838480
      Consensus CDS
      CCDS23237.1
      UniProtKB/Swiss-Prot
      Q6GU68
      UniProtKB/TrEMBL
      A0A146E664
      Related
      ENSMUSP00000126963.3, ENSMUST00000168864.4
      Conserved Domains (6) summary
      cd00096
      Location:255 → 341
      Ig; Immunoglobulin domain
      smart00082
      Location:180 → 228
      LRRCT; Leucine rich repeat C-terminal domain
      cd00116
      Location:50 → 181
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      pfam07679
      Location:239 → 343
      I-set; Immunoglobulin I-set domain
      sd00033
      Location:32 → 51
      LRR_RI; leucine-rich repeat [structural motif]
      pfam13855
      Location:98 → 158
      LRR_8; Leucine rich repeat

    2. NM_012043.4 → NP_036173.1  immunoglobulin superfamily containing leucine-rich repeat protein precursor

      See identical proteins and their annotated locations for NP_036173.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      AC158996, AC160976, AI838480
      Consensus CDS
      CCDS23237.1
      UniProtKB/Swiss-Prot
      Q6GU68
      UniProtKB/TrEMBL
      A0A146E664
      Related
      ENSMUSP00000045142.8, ENSMUST00000041477.15
      Conserved Domains (6) summary
      cd00096
      Location:255 → 341
      Ig; Immunoglobulin domain
      smart00082
      Location:180 → 228
      LRRCT; Leucine rich repeat C-terminal domain
      cd00116
      Location:50 → 181
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      pfam07679
      Location:239 → 343
      I-set; Immunoglobulin I-set domain
      sd00033
      Location:32 → 51
      LRR_RI; leucine-rich repeat [structural motif]
      pfam13855
      Location:98 → 158
      LRR_8; Leucine rich repeat

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      58063547..58066563 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006511204.4 → XP_006511267.1  immunoglobulin superfamily containing leucine-rich repeat protein isoform X1

      See identical proteins and their annotated locations for XP_006511267.1

      Conserved Domains (4) summary
      TIGR00864
      Location:161 → 235
      PCC; polycystin cation channel protein
      sd00033
      Location:40 → 59
      LRR_RI; leucine-rich repeat [structural motif]
      cd00096
      Location:263 → 349
      Ig; Immunoglobulin domain
      pfam13855
      Location:107 → 166
      LRR_8; Leucine rich repeat

    2. XM_011242750.4 → XP_011241052.1  immunoglobulin superfamily containing leucine-rich repeat protein isoform X1

      See identical proteins and their annotated locations for XP_011241052.1

      Conserved Domains (4) summary
      TIGR00864
      Location:161 → 235
      PCC; polycystin cation channel protein
      sd00033
      Location:40 → 59
      LRR_RI; leucine-rich repeat [structural motif]
      cd00096
      Location:263 → 349
      Ig; Immunoglobulin domain
      pfam13855
      Location:107 → 166
      LRR_8; Leucine rich repeat
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6GU68.1 GenPept UniProtKB/Swiss-Prot:Q6GU68

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