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    Slc2a4 solute carrier family 2 (facilitated glucose transporter), member 4 [ Mus musculus (house mouse) ]

    Gene ID: 20528, updated on 27-Nov-2024

    Summary

    Official Symbol
    Slc2a4provided by MGI
    Official Full Name
    solute carrier family 2 (facilitated glucose transporter), member 4provided by MGI
    Primary source
    MGI:MGI:95758
    See related
    Ensembl:ENSMUSG00000018566 AllianceGenome:MGI:95758
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    GT2; twgy; Glut4; Glut-4
    Summary
    Enables D-glucose transmembrane transporter activity. Involved in glucose import in response to insulin stimulus. Acts upstream of or within several processes, including amylopectin biosynthetic process; brown fat cell differentiation; and cellular response to tumor necrosis factor. Located in several cellular components, including cytoplasmic vesicle; extracellular exosome; and sarcolemma. Is expressed in several structures, including adipose tissue; alimentary system; central nervous system; genitourinary system; and sensory organ. Used to study type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in type 2 diabetes mellitus. Orthologous to human SLC2A4 (solute carrier family 2 member 4). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in heart adult (RPKM 161.8), mammary gland adult (RPKM 97.3) and 12 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Slc2a4 in Genome Data Viewer
    Location:
    11 B3; 11 42.93 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (69833112..69839040, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (69942286..69948216, complement)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E8420 Neighboring gene G protein pathway suppressor 2 Neighboring gene STARR-positive B cell enhancer ABC_E1831 Neighboring gene eukaryotic translation initiation factor 5A Neighboring gene Y box protein 2 Neighboring gene STARR-positive B cell enhancer ABC_E9140 Neighboring gene cofilin 1, non-muscle pseudogene Neighboring gene claudin 7

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Chemically induced (ENU) (1) 
    • Endonuclease-mediated (3) 
    • Targeted (3)  1 citation

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables D-glucose transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables D-glucose transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables D-glucose transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables D-glucose transmembrane transporter activity TAS
    Traceable Author Statement
    more info
    PubMed 
    enables D-glucose uniporter activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables D-glucose uniporter activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables insulin-responsive D-glucose:proton symporter activity TAS
    Traceable Author Statement
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in D-glucose import IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in D-glucose import ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within D-glucose transmembrane transport IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in D-glucose transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within D-glucose transmembrane transport TAS
    Traceable Author Statement
    more info
    PubMed 
    acts_upstream_of_or_within amylopectin biosynthetic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within brown fat cell differentiation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in cellular response to hypoxia IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to hypoxia ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to insulin stimulus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within cellular response to insulin stimulus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in cellular response to insulin stimulus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in cellular response to insulin stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within cellular response to osmotic stress IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within cellular response to tumor necrosis factor IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in dehydroascorbic acid transport IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within glucose homeostasis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in glucose homeostasis ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within glucose import in response to insulin stimulus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in glucose import in response to insulin stimulus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in glucose import in response to insulin stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within learning or memory ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in long-term memory IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within_positive_effect long-term memory ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of brain-derived neurotrophic factor receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within positive regulation of brain-derived neurotrophic factor receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of synaptic vesicle budding from presynaptic endocytic zone membrane IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of synaptic vesicle budding from presynaptic endocytic zone membrane ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to ethanol IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in short-term memory IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within_negative_effect short-term memory ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in T-tubule IEA
    Inferred from Electronic Annotation
    more info
     
    located_in T-tubule ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cell surface ISO
    Inferred from Sequence Orthology
    more info
     
    located_in clathrin-coated pit IEA
    Inferred from Electronic Annotation
    more info
     
    located_in clathrin-coated pit ISO
    Inferred from Sequence Orthology
    more info
     
    located_in clathrin-coated vesicle ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasmic vesicle membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasmic vesicle membrane TAS
    Traceable Author Statement
    more info
    PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in endomembrane system IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in endomembrane system IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in endosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in endosome ISO
    Inferred from Sequence Orthology
    more info
     
    located_in external side of plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in extracellular exosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in insulin-responsive compartment IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in insulin-responsive compartment ISO
    Inferred from Sequence Orthology
    more info
     
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in membrane raft IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in multivesicular body IEA
    Inferred from Electronic Annotation
    more info
     
    located_in multivesicular body ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in perinuclear region of cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in perinuclear region of cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
     
    located_in presynapse IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in presynapse ISO
    Inferred from Sequence Orthology
    more info
     
    located_in sarcolemma IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in sarcolemma ISO
    Inferred from Sequence Orthology
    more info
     
    located_in sarcoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
     
    located_in sarcoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
     
    located_in trans-Golgi network IEA
    Inferred from Electronic Annotation
    more info
     
    located_in trans-Golgi network ISO
    Inferred from Sequence Orthology
    more info
     
    located_in trans-Golgi network transport vesicle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in vesicle ISO
    Inferred from Sequence Orthology
    more info
     
    located_in vesicle membrane ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    solute carrier family 2, facilitated glucose transporter member 4
    Names
    glucose transporter type 4, insulin-responsive

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001359114.2NP_001346043.1  solute carrier family 2, facilitated glucose transporter member 4 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region and initiates translation at a downstream start codon, compared to variant 1. It encodes isoform 2, which has a shorter N-terminus, compared to isoform 1.
      Source sequence(s)
      AL596185
      Conserved Domains (1) summary
      cl28910
      Location:1382
      MFS; Major Facilitator Superfamily
    2. NM_009204.3NP_033230.2  solute carrier family 2, facilitated glucose transporter member 4 isoform 1

      See identical proteins and their annotated locations for NP_033230.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      AL596185
      Consensus CDS
      CCDS36201.1
      UniProtKB/Swiss-Prot
      P14142, Q3TPK6, Q9JJN9
      UniProtKB/TrEMBL
      J3QK17
      Related
      ENSMUSP00000018710.7, ENSMUST00000018710.13
      Conserved Domains (2) summary
      cd06174
      Location:78447
      MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
      pfam00083
      Location:27483
      Sugar_tr; Sugar (and other) transporter

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      69833112..69839040 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030245725.2XP_030101585.1  solute carrier family 2, facilitated glucose transporter member 4 isoform X2

      Conserved Domains (1) summary
      cl28910
      Location:1317
      MFS; Major Facilitator Superfamily
    2. XM_006532655.4XP_006532718.1  solute carrier family 2, facilitated glucose transporter member 4 isoform X2

      See identical proteins and their annotated locations for XP_006532718.1

      Conserved Domains (1) summary
      cl28910
      Location:1317
      MFS; Major Facilitator Superfamily
    3. XM_006532654.3XP_006532717.1  solute carrier family 2, facilitated glucose transporter member 4 isoform X1

      See identical proteins and their annotated locations for XP_006532717.1

      Conserved Domains (1) summary
      cl28910
      Location:1382
      MFS; Major Facilitator Superfamily