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    Wscd1 WSC domain containing 1 [ Mus musculus (house mouse) ]

    Gene ID: 216881, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Wscd1provided by MGI
    Official Full Name
    WSC domain containing 1provided by MGI
    Primary source
    MGI:MGI:2448493
    See related
    Ensembl:ENSMUSG00000020811 AllianceGenome:MGI:2448493
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    mKIAA0523
    Summary
    Enables sulfotransferase activity. Located in Golgi membrane. Is expressed in several structures, including metanephros; nervous system; sensory organ; tooth; and ventricle cardiac muscle. Orthologous to human WSCD1 (WSC domain containing 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in cerebellum adult (RPKM 18.0), lung adult (RPKM 15.1) and 14 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Wscd1 in Genome Data Viewer
    Location:
    11 B4; 11 43.62 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (71640719..71680475)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (71749893..71789649)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 33964 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:71483619-71483785 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:71483854-71484055 Neighboring gene STARR-seq mESC enhancer starr_29891 Neighboring gene STARR-seq mESC enhancer starr_29892 Neighboring gene predicted gene 12326 Neighboring gene STARR-seq mESC enhancer starr_29893 Neighboring gene predicted gene, 34127 Neighboring gene predicted gene, 22927

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Sulfation of sialic acid is ubiquitous and essential for vertebrate development. Ertunc N, et al. Sci Rep, 2022 Jul 21. PMID 35864127, Free PMC Article
    2. Spatial and temporal analysis of gene expression during growth and fusion of the mouse facial prominences. Feng W, et al. PLoS One, 2009 Dec 16. PMID 20016822, Free PMC Article
    3. Novel genes differentially expressed in cortical regions during late neurogenesis. Mühlfriedel S, et al. Eur J Neurosci, 2007 Jul. PMID 17614941
    4. The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data. Koscielny G, et al. Nucleic Acids Res, 2014 Jan. PMID 24194600, Free PMC Article
    5. Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development. Bedogni F, et al. Front Mol Neurosci, 2021. PMID 34321999, Free PMC Article

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (2) 

    General gene information

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    Homology

    Clone Names

    • KIAA0523, MGC55022

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    enables sulfotransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  

    General protein information

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    Preferred Names
    sialate:O-sulfotransferase 1
    Names
    WSC domain-containing protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001357960.1 → NP_001344889.1  sialate:O-sulfotransferase 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 3. Variants 1, 2 and 3 encode the same protein.
      Source sequence(s)
      BC063070, BM949874, BQ043204, BY267133
      Consensus CDS
      CCDS24975.1
      UniProtKB/Swiss-Prot
      Q3TQ40, Q5DU24, Q80XH4, Q8BX34
      Conserved Domains (2) summary
      smart00321
      Location:139 → 231
      WSC; present in yeast cell wall integrity and stress response component proteins
      cl21551
      Location:422 → 551
      Sulfotransfer_3; Sulfotransferase family

    2. NM_001357965.1 → NP_001344894.1  sialate:O-sulfotransferase 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) represents the longest transcript. Variants 1, 2 and 3 encode the same protein.
      Source sequence(s)
      BB647482, BC063070, BQ043204, CX219865
      Consensus CDS
      CCDS24975.1
      UniProtKB/Swiss-Prot
      Q3TQ40, Q5DU24, Q80XH4, Q8BX34
      Related
      ENSMUSP00000104151.2, ENSMUST00000108511.8
      Conserved Domains (2) summary
      smart00321
      Location:139 → 231
      WSC; present in yeast cell wall integrity and stress response component proteins
      cl21551
      Location:422 → 551
      Sulfotransfer_3; Sulfotransferase family

    3. NM_177618.4 → NP_808286.2  sialate:O-sulfotransferase 1

      See identical proteins and their annotated locations for NP_808286.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) differs in the 5' UTR, compared to variant 3. Variants 1, 2 and 3 encode the same protein.
      Source sequence(s)
      BC063070
      Consensus CDS
      CCDS24975.1
      UniProtKB/Swiss-Prot
      Q3TQ40, Q5DU24, Q80XH4, Q8BX34
      Related
      ENSMUSP00000021168.8, ENSMUST00000021168.14
      Conserved Domains (2) summary
      smart00321
      Location:139 → 231
      WSC; present in yeast cell wall integrity and stress response component proteins
      cl21551
      Location:422 → 551
      Sulfotransfer_3; Sulfotransferase family

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      71640719..71680475
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006532929.4 → XP_006532992.1  sialate:O-sulfotransferase 1 isoform X1

      See identical proteins and their annotated locations for XP_006532992.1

      UniProtKB/Swiss-Prot
      Q3TQ40, Q5DU24, Q80XH4, Q8BX34
      Conserved Domains (2) summary
      smart00321
      Location:139 → 231
      WSC; present in yeast cell wall integrity and stress response component proteins
      cl21551
      Location:422 → 551
      Sulfotransfer_3; Sulfotransferase family

    2. XM_036156577.1 → XP_036012470.1  sialate:O-sulfotransferase 1 isoform X1

      UniProtKB/Swiss-Prot
      Q3TQ40, Q5DU24, Q80XH4, Q8BX34
      Conserved Domains (2) summary
      smart00321
      Location:139 → 231
      WSC; present in yeast cell wall integrity and stress response component proteins
      cl21551
      Location:422 → 551
      Sulfotransfer_3; Sulfotransferase family

    3. XM_006532931.5 → XP_006532994.1  sialate:O-sulfotransferase 1 isoform X1

      See identical proteins and their annotated locations for XP_006532994.1

      UniProtKB/Swiss-Prot
      Q3TQ40, Q5DU24, Q80XH4, Q8BX34
      Related
      ENSMUSP00000104150.2, ENSMUST00000108510.2
      Conserved Domains (2) summary
      smart00321
      Location:139 → 231
      WSC; present in yeast cell wall integrity and stress response component proteins
      cl21551
      Location:422 → 551
      Sulfotransfer_3; Sulfotransferase family

    4. XM_006532932.4 → XP_006532995.1  sialate:O-sulfotransferase 1 isoform X2

      Conserved Domains (2) summary
      smart00321
      Location:7 → 102
      WSC; present in yeast cell wall integrity and stress response component proteins
      cl21551
      Location:187 → 316
      Sulfotransfer_3; Sulfotransferase family

    RNA

    1. XR_004936917.1 RNA Sequence

    2. XR_003949388.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q80XH4.1 GenPept UniProtKB/Swiss-Prot:Q80XH4

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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