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    Tmc6 transmembrane channel-like gene family 6 [ Mus musculus (house mouse) ]

    Gene ID: 217353, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Tmc6provided by MGI
    Official Full Name
    transmembrane channel-like gene family 6provided by MGI
    Primary source
    MGI:MGI:1098686
    See related
    Ensembl:ENSMUSG00000025572 AllianceGenome:MGI:1098686
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    EVER1; D11Ertd204e
    Summary
    Predicted to enable mechanosensitive monoatomic ion channel activity. Involved in protein stabilization. Predicted to be located in Golgi apparatus; endoplasmic reticulum; and nuclear membrane. Human ortholog(s) of this gene implicated in epidermodysplasia verruciformis. Orthologous to human TMC6 (transmembrane channel like 6). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in thymus adult (RPKM 37.8), spleen adult (RPKM 30.5) and 20 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Tmc6 in Genome Data Viewer
    Location:
    11 E2; 11 82.96 cM
    Exon count:
    29
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (117656811..117673019, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (117765985..117782193, complement)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 2900041M22 gene Neighboring gene predicted gene, 35170 Neighboring gene STARR-seq mESC enhancer starr_31269 Neighboring gene STARR-positive B cell enhancer ABC_E2377 Neighboring gene STARR-positive B cell enhancer ABC_E5303 Neighboring gene trinucleotide repeat containing 6C Neighboring gene STARR-seq mESC enhancer starr_31271 Neighboring gene STARR-seq mESC enhancer starr_31272 Neighboring gene STARR-positive B cell enhancer ABC_E1437 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:117642510-117642724 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:117643420-117643529 Neighboring gene STARR-positive B cell enhancer ABC_E5304 Neighboring gene STARR-positive B cell enhancer ABC_E9147 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:117655547-117655805 Neighboring gene RIKEN cDNA 6030468B19 gene Neighboring gene predicted gene 11723 Neighboring gene STARR-positive B cell enhancer ABC_E5305 Neighboring gene transmembrane channel-like gene family 8

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Expression of a TMC6-TMC8-CIB1 heterotrimeric complex in lymphocytes is regulated by each of the components. Wu CJ, et al. J Biol Chem, 2020 Nov 20. PMID 32917726, Free PMC Article
    2. Characterization of the transmembrane channel-like (TMC) gene family: functional clues from hearing loss and epidermodysplasia verruciformis. Kurima K, et al. Genomics, 2003 Sep. PMID 12906855
    3. TMC and EVER genes belong to a larger novel family, the TMC gene family encoding transmembrane proteins. Keresztes G, et al. BMC Genomics, 2003 Jun 17. PMID 12812529, Free PMC Article
    4. Novel skin phenotypes revealed by a genome-wide mouse reverse genetic screen. Liakath-Ali K, et al. Nat Commun, 2014 Apr 11. PMID 24721909, Free PMC Article
    5. Construction of a multi-functional cDNA library specific for mouse pancreatic islets and its application to microarray. Nishimura M, et al. DNA Res, 2004 Oct 31. PMID 15747579

    See all (24) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Expression of a TMC6-TMC8-CIB1 heterotrimeric complex in lymphocytes is regulated by each of the components.
      Title: Expression of a TMC6-TMC8-CIB1 heterotrimeric complex in lymphocytes is regulated by each of the components.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (2)  1 citation

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables mechanosensitive monoatomic ion channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in intracellular zinc ion homeostasis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in protein stabilization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nuclear membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    transmembrane channel-like protein 6

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_145439.3 → NP_663414.3  transmembrane channel-like protein 6

      See identical proteins and their annotated locations for NP_663414.3

      Status: VALIDATED

      Source sequence(s)
      AK052814, AL645856, AY263158, BP767442
      Consensus CDS
      CCDS25687.1
      UniProtKB/Swiss-Prot
      B1ATB4, Q78JR7, Q7TN60, Q7TQ68, Q8BP52, Q8C6Z5, Q99J32
      UniProtKB/TrEMBL
      B1ATB3
      Related
      ENSMUSP00000026659.4, ENSMUST00000026659.10
      Conserved Domains (1) summary
      pfam07810
      Location:539 → 645
      TMC; TMC domain

    RNA

    1. NR_154387.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AK077671, AL645856, BP767442
      Related
      ENSMUST00000131606.8

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      117656811..117673019 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006533115.2 → XP_006533178.1  transmembrane channel-like protein 6 isoform X1

      See identical proteins and their annotated locations for XP_006533178.1

      UniProtKB/Swiss-Prot
      B1ATB4, Q78JR7, Q7TN60, Q7TQ68, Q8BP52, Q8C6Z5, Q99J32
      UniProtKB/TrEMBL
      B1ATB3
      Conserved Domains (1) summary
      pfam07810
      Location:539 → 645
      TMC; TMC domain

    2. XM_006533116.2 → XP_006533179.1  transmembrane channel-like protein 6 isoform X1

      See identical proteins and their annotated locations for XP_006533179.1

      UniProtKB/Swiss-Prot
      B1ATB4, Q78JR7, Q7TN60, Q7TQ68, Q8BP52, Q8C6Z5, Q99J32
      UniProtKB/TrEMBL
      B1ATB3
      Conserved Domains (1) summary
      pfam07810
      Location:539 → 645
      TMC; TMC domain

    3. XM_006533114.5 → XP_006533177.1  transmembrane channel-like protein 6 isoform X1

      See identical proteins and their annotated locations for XP_006533177.1

      UniProtKB/Swiss-Prot
      B1ATB4, Q78JR7, Q7TN60, Q7TQ68, Q8BP52, Q8C6Z5, Q99J32
      UniProtKB/TrEMBL
      B1ATB3
      Conserved Domains (1) summary
      pfam07810
      Location:539 → 645
      TMC; TMC domain

    4. XM_006533118.5 → XP_006533181.1  transmembrane channel-like protein 6 isoform X3

      See identical proteins and their annotated locations for XP_006533181.1

      UniProtKB/Swiss-Prot
      B1ATB4, Q78JR7, Q7TN60, Q7TQ68, Q8BP52, Q8C6Z5, Q99J32
      Conserved Domains (1) summary
      pfam07810
      Location:491 → 597
      TMC; TMC domain

    5. XM_006533117.5 → XP_006533180.1  transmembrane channel-like protein 6 isoform X2

      UniProtKB/Swiss-Prot
      B1ATB4, Q78JR7, Q7TN60, Q7TQ68, Q8BP52, Q8C6Z5, Q99J32
      Conserved Domains (1) summary
      pfam07810
      Location:535 → 641
      TMC; TMC domain

    6. XM_006533112.5 → XP_006533175.1  transmembrane channel-like protein 6 isoform X1

      See identical proteins and their annotated locations for XP_006533175.1

      UniProtKB/Swiss-Prot
      B1ATB4, Q78JR7, Q7TN60, Q7TQ68, Q8BP52, Q8C6Z5, Q99J32
      UniProtKB/TrEMBL
      B1ATB3
      Conserved Domains (1) summary
      pfam07810
      Location:539 → 645
      TMC; TMC domain

    7. XM_030245908.2 → XP_030101768.1  transmembrane channel-like protein 6 isoform X2

      UniProtKB/Swiss-Prot
      B1ATB4, Q78JR7, Q7TN60, Q7TQ68, Q8BP52, Q8C6Z5, Q99J32
      Conserved Domains (1) summary
      pfam07810
      Location:535 → 641
      TMC; TMC domain

    8. XM_006533113.5 → XP_006533176.1  transmembrane channel-like protein 6 isoform X1

      See identical proteins and their annotated locations for XP_006533176.1

      UniProtKB/Swiss-Prot
      B1ATB4, Q78JR7, Q7TN60, Q7TQ68, Q8BP52, Q8C6Z5, Q99J32
      UniProtKB/TrEMBL
      B1ATB3
      Conserved Domains (1) summary
      pfam07810
      Location:539 → 645
      TMC; TMC domain

    9. XM_006533119.5 → XP_006533182.1  transmembrane channel-like protein 6 isoform X3

      See identical proteins and their annotated locations for XP_006533182.1

      UniProtKB/Swiss-Prot
      B1ATB4, Q78JR7, Q7TN60, Q7TQ68, Q8BP52, Q8C6Z5, Q99J32
      Conserved Domains (1) summary
      pfam07810
      Location:491 → 597
      TMC; TMC domain

    10. XM_030245907.2 → XP_030101767.1  transmembrane channel-like protein 6 isoform X2

      UniProtKB/Swiss-Prot
      B1ATB4, Q78JR7, Q7TN60, Q7TQ68, Q8BP52, Q8C6Z5, Q99J32
      Conserved Domains (1) summary
      pfam07810
      Location:535 → 641
      TMC; TMC domain

    11. XM_006533120.4 → XP_006533183.1  transmembrane channel-like protein 6 isoform X4

      Conserved Domains (1) summary
      pfam07810
      Location:539 → 638
      TMC; TMC domain

    12. XM_006533122.5 → XP_006533185.1  transmembrane channel-like protein 6 isoform X5

    RNA

    1. XR_004936931.1 RNA Sequence

    2. XR_004936932.1 RNA Sequence

    3. XR_003949405.2 RNA Sequence

    4. XR_388423.5 RNA Sequence

    5. XR_003949404.2 RNA Sequence

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_181321.3: Suppressed sequence

      Description
      NM_181321.3: This RefSeq was removed because currently there is insufficient support for the transcript and protein.
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7TN60.2 GenPept UniProtKB/Swiss-Prot:Q7TN60

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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