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    Sectm1b secreted and transmembrane 1B [ Mus musculus (house mouse) ]

    Gene ID: 58210, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Sectm1bprovided by MGI
    Official Full Name
    secreted and transmembrane 1Bprovided by MGI
    Primary source
    MGI:MGI:1929083
    See related
    Ensembl:ENSMUSG00000039364 AllianceGenome:MGI:1929083
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    K12; Sectm1; 1810003C24Rik
    Summary
    Predicted to enable cytokine activity. Predicted to be involved in immune response and signal transduction. Predicted to be located in plasma membrane. Predicted to be active in membrane. Orthologous to human SECTM1 (secreted and transmembrane 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in large intestine adult (RPKM 72.9), small intestine adult (RPKM 72.4) and 4 other tissues See more
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    Genomic context

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    See Sectm1b in Genome Data Viewer
    Location:
    11 E2; 11 84.87 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (120944248..120954377, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (121053423..121063585, complement)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 22152 Neighboring gene predicted gene 11775 Neighboring gene CD7 antigen Neighboring gene secreted and transmembrane 1A Neighboring gene predicted gene 11793

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Identification of a Novel Antisepsis Pathway: Sectm1a Enhances Macrophage Phagocytosis of Bacteria through Activating GITR. Mu X, et al. J Immunol, 2020 Sep 15. PMID 32769121, Free PMC Article
    2. Identification of CD7 as a cognate of the human K12 (SECTM1) protein. Lyman SD, et al. J Biol Chem, 2000 Feb 4. PMID 10652336
    3. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
    4. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Identification of a Novel Antisepsis Pathway: Sectm1a Enhances Macrophage Phagocytosis of Bacteria through Activating GITR.
      Title: Identification of a Novel Antisepsis Pathway: Sectm1a Enhances Macrophage Phagocytosis of Bacteria through Activating GITR.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (1) 

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables cytokine activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in immune response IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    secreted and transmembrane protein 1b

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001419037.1 → NP_001405966.1  secreted and transmembrane protein 1b precursor

      Status: VALIDATED

      Source sequence(s)
      AL662887
      UniProtKB/TrEMBL
      Q9D966

    2. NM_001419038.1 → NP_001405967.1  secreted and transmembrane protein 1b precursor

      Status: VALIDATED

      Source sequence(s)
      AL662887
      UniProtKB/TrEMBL
      Q9D966
      Related
      ENSMUSP00000125965.2, ENSMUST00000168459.8

    3. NM_001419039.1 → NP_001405968.1  secreted and transmembrane protein 1b precursor

      Status: VALIDATED

      Source sequence(s)
      AL662887
      UniProtKB/TrEMBL
      Q9D966
      Related
      ENSMUSP00000116010.2, ENSMUST00000130786.2

    4. NM_026907.4 → NP_081183.3  secreted and transmembrane protein 1b precursor

      See identical proteins and their annotated locations for NP_081183.3

      Status: VALIDATED

      Source sequence(s)
      AL662887
      Consensus CDS
      CCDS25765.1
      UniProtKB/TrEMBL
      Q8CE38, Q9D966
      Related
      ENSMUSP00000045748.6, ENSMUST00000039309.12
      Conserved Domains (1) summary
      cl11960
      Location:39 → 116
      Ig; Immunoglobulin domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      120944248..120954377 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006533854.1 → XP_006533917.1  secreted and transmembrane protein 1b isoform X1

      See identical proteins and their annotated locations for XP_006533917.1

      UniProtKB/TrEMBL
      Q8CE38, Q9D966
      Related
      ENSMUSP00000080217.3, ENSMUST00000081499.9
      Conserved Domains (1) summary
      cl11960
      Location:39 → 116
      Ig; Immunoglobulin domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9JL59.1 GenPept UniProtKB/Swiss-Prot:Q9JL59

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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